SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5k1c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		 5k1c WD REPEAT-CONTAINING
PROTEIN 20
(Homo
sapiens) 		5 / 10 TYR C  74
PHE C  67
VAL C  69
VAL C  50
GLY C 553
 None
 1.37A 13gsA-5k1cC:
undetectable		 13gsA-5k1cC:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5k1c WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		5 / 9 GLY B 232
THR B 247
THR B 233
GLY B 208
THR B 210
 None
 1.18A 1c9sQ-5k1cB:
undetectable
1c9sR-5k1cB:
undetectable		 1c9sQ-5k1cB:
11.98
1c9sR-5k1cB:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5k1c WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		5 / 10 GLY B 208
THR B 210
GLY B 232
THR B 247
THR B 233
 None
 1.17A 1c9sL-5k1cB:
undetectable
1c9sV-5k1cB:
undetectable		 1c9sL-5k1cB:
11.98
1c9sV-5k1cB:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_R_TRPR81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5k1c WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		5 / 9 GLY B 232
THR B 247
THR B 233
GLY B 208
THR B 210
 None
 1.18A 1gtfR-5k1cB:
undetectable
1gtfS-5k1cB:
undetectable		 1gtfR-5k1cB:
11.98
1gtfS-5k1cB:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5k1c WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		5 / 11 GLY B 232
THR B 247
THR B 233
GLY B 208
THR B 210
 None
 1.16A 1gtnT-5k1cB:
undetectable
1gtnU-5k1cB:
undetectable		 1gtnT-5k1cB:
11.98
1gtnU-5k1cB:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_A_HSMA502_1
(HISTIDINOL
DEHYDROGENASE)		 5k1c UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 12
WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		5 / 9 SER B 170
HIS A 243
TYR B 172
GLU A 241
LEU A 187
 None
 1.34A 1karA-5k1cB:
0.0
1karB-5k1cB:
0.0		 1karA-5k1cB:
22.20
1karB-5k1cB:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_B_HSMB503_1
(HISTIDINOL
DEHYDROGENASE)		 5k1c UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 12
WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		5 / 9 GLU A 241
LEU A 187
SER B 170
HIS A 243
TYR B 172
 None
 1.31A 1karA-5k1cA:
0.0
1karB-5k1cA:
0.0		 1karA-5k1cA:
20.97
1karB-5k1cA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 5k1c UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 12
(Homo
sapiens) 		5 / 12 VAL A 278
LEU A 259
SER A 203
LEU A 202
THR A 210
 None
 1.34A 1kw0A-5k1cA:
undetectable		 1kw0A-5k1cA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA8_0
(GRAMICIDIN A)		 5k1c WD REPEAT-CONTAINING
PROTEIN 20
(Homo
sapiens) 		4 / 4 GLY C 373
VAL C 309
TRP C 306
GLY C 281
 None
 1.43A 1ng8A-5k1cC:
undetectable		 1ng8A-5k1cC:
2.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA8_0
(GRAMICIDIN A)		 5k1c WD REPEAT-CONTAINING
PROTEIN 20
(Homo
sapiens) 		4 / 4 GLY C 373
VAL C 309
TRP C 381
GLY C 370
 None
 1.05A 1ng8A-5k1cC:
undetectable		 1ng8A-5k1cC:
2.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB8_0
(GRAMICIDIN A)		 5k1c WD REPEAT-CONTAINING
PROTEIN 20
(Homo
sapiens) 		4 / 4 GLY C 373
VAL C 309
TRP C 306
GLY C 281
 None
 1.43A 1ng8B-5k1cC:
undetectable		 1ng8B-5k1cC:
2.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB8_0
(GRAMICIDIN A)		 5k1c WD REPEAT-CONTAINING
PROTEIN 20
(Homo
sapiens) 		4 / 4 GLY C 373
VAL C 309
TRP C 381
GLY C 370
 None
 1.05A 1ng8B-5k1cC:
undetectable		 1ng8B-5k1cC:
2.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_U_TRPU81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5k1c WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		5 / 10 GLY B 232
THR B 247
THR B 233
GLY B 208
THR B 210
 None
 1.17A 1utdU-5k1cB:
undetectable
1utdV-5k1cB:
undetectable		 1utdU-5k1cB:
11.98
1utdV-5k1cB:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 5k1c WD REPEAT-CONTAINING
PROTEIN 20
(Homo
sapiens) 		5 / 12 PRO C  28
SER C  33
TYR C  32
ILE C 555
LEU C  87
 None
 1.20A 1z9hA-5k1cC:
undetectable		 1z9hA-5k1cC:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 5k1c WD REPEAT-CONTAINING
PROTEIN 20
(Homo
sapiens) 		5 / 12 PRO C  28
SER C  33
TYR C  32
ILE C 555
LEU C  87
 None
 1.19A 1z9hB-5k1cC:
undetectable		 1z9hB-5k1cC:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 5k1c WD REPEAT-CONTAINING
PROTEIN 20
(Homo
sapiens) 		5 / 12 PRO C  28
SER C  33
TYR C  32
ILE C 555
LEU C  87
 None
 1.21A 1z9hC-5k1cC:
undetectable		 1z9hC-5k1cC:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 5k1c WD REPEAT-CONTAINING
PROTEIN 20
(Homo
sapiens) 		5 / 12 PRO C  28
SER C  33
TYR C  32
ILE C 555
LEU C  87
 None
 1.21A 1z9hD-5k1cC:
undetectable		 1z9hD-5k1cC:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5k1c WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		4 / 5 ILE B  21
ILE B  53
ILE B 363
LEU B 529
 None
 0.87A 1zgyA-5k1cB:
undetectable		 1zgyA-5k1cB:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5k1c WD REPEAT-CONTAINING
PROTEIN 20
(Homo
sapiens) 		5 / 12 VAL C 296
ALA C 298
LEU C 522
LEU C 285
SER C 260
 None
 1.15A 2oipC-5k1cC:
undetectable		 2oipC-5k1cC:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 5k1c WD REPEAT-CONTAINING
PROTEIN 20
(Homo
sapiens) 		4 / 7 LEU C 378
PHE C  17
ILE C 546
GLU C  21
 None
 0.81A 2opxA-5k1cC:
undetectable		 2opxA-5k1cC:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		 5k1c WD REPEAT-CONTAINING
PROTEIN 20
(Homo
sapiens) 		4 / 6 SER C 171
TYR C 175
VAL C 167
ASP C 148
 None
 1.33A 2x45A-5k1cC:
undetectable		 2x45A-5k1cC:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5k1c WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		5 / 12 CYH B 109
ALA B 104
ALA B  48
VAL B  78
LEU B 113
 None
 1.16A 3b0wA-5k1cB:
undetectable		 3b0wA-5k1cB:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5k1c WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		5 / 12 CYH B 109
ALA B 104
ALA B  48
VAL B  78
LEU B 113
 None
 1.15A 3b0wB-5k1cB:
undetectable		 3b0wB-5k1cB:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5k1c WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		4 / 7 PHE B 264
GLN B 224
LEU B 226
LEU B 236
 None
 0.56A 3bgdB-5k1cB:
undetectable		 3bgdB-5k1cB:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_1
(SPERMIDINE SYNTHASE)		 5k1c WD REPEAT-CONTAINING
PROTEIN 48
WD REPEAT-CONTAINING
PROTEIN 20
(Homo
sapiens;
Homo
sapiens) 		4 / 5 GLN B 242
ASP C 382
ASP C 313
THR C  19
 None
 1.07A 3bwcB-5k1cB:
2.7		 3bwcB-5k1cB:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 5k1c UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 12
WD REPEAT-CONTAINING
PROTEIN 20
(Homo
sapiens) 		3 / 3 ARG A 277
VAL C  48
THR C 537
 None
 0.65A 3cyxA-5k1cA:
undetectable		 3cyxA-5k1cA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5k1c WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		4 / 7 GLY B 270
VAL B 297
ILE B 290
GLN B 259
 None
 0.85A 3fi0P-5k1cB:
undetectable		 3fi0P-5k1cB:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 5k1c UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 12
WD REPEAT-CONTAINING
PROTEIN 20
(Homo
sapiens;
Homo
sapiens) 		4 / 7 GLN C 374
GLY C  44
THR A 351
GLU A 345
 None
 0.87A 3fpjB-5k1cC:
undetectable		 3fpjB-5k1cC:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5k1c WD REPEAT-CONTAINING
PROTEIN 20
(Homo
sapiens) 		4 / 7 MET C 174
ARG C 245
SER C 150
GLY C 221
 None
 1.11A 3hcnA-5k1cC:
undetectable		 3hcnA-5k1cC:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5k1c WD REPEAT-CONTAINING
PROTEIN 20
(Homo
sapiens) 		5 / 12 VAL C 296
ALA C 298
LEU C 522
LEU C 285
SER C 260
 None
 1.09A 3hj3D-5k1cC:
undetectable		 3hj3D-5k1cC:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 5k1c WD REPEAT-CONTAINING
PROTEIN 20
(Homo
sapiens) 		3 / 3 ASP C 273
PHE C 312
SER C 290
 None
 0.96A 3i5uB-5k1cC:
undetectable		 3i5uB-5k1cC:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5k1c UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 12
WD REPEAT-CONTAINING
PROTEIN 20
(Homo
sapiens;
Homo
sapiens) 		5 / 11 GLY C 263
THR A 213
GLU A 283
ASP C 241
ASP C 283
 None
 1.27A 3id5B-5k1cC:
undetectable		 3id5B-5k1cC:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5k1c UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 12
WD REPEAT-CONTAINING
PROTEIN 20
(Homo
sapiens;
Homo
sapiens) 		5 / 11 GLY C 263
THR A 213
GLU A 283
ASP C 241
ASP C 283
 None
 1.27A 3id5F-5k1cC:
undetectable		 3id5F-5k1cC:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5k1c UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 12
WD REPEAT-CONTAINING
PROTEIN 20
(Homo
sapiens;
Homo
sapiens) 		5 / 12 GLY C 263
THR A 213
GLU A 283
ASP C 241
ASP C 283
 None
 1.11A 3id6C-5k1cC:
undetectable		 3id6C-5k1cC:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5k1c WD REPEAT-CONTAINING
PROTEIN 20
(Homo
sapiens) 		5 / 12 ARG C  20
PHE C 389
ILE C 297
ARG C 368
LEU C 383
 None
 1.32A 3iv6C-5k1cC:
undetectable		 3iv6C-5k1cC:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_B_EAAB222_1
(GLUTATHIONE
S-TRANSFERASE P)		 5k1c WD REPEAT-CONTAINING
PROTEIN 20
(Homo
sapiens) 		5 / 9 TYR C  74
PHE C  67
VAL C  69
VAL C  50
GLY C 553
 None
 1.41A 3km6B-5k1cC:
undetectable		 3km6B-5k1cC:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 5k1c WD REPEAT-CONTAINING
PROTEIN 20
(Homo
sapiens) 		5 / 9 TYR C  74
PHE C  67
VAL C  69
VAL C  50
GLY C 553
 None
 1.43A 3kmoA-5k1cC:
undetectable		 3kmoA-5k1cC:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 5k1c WD REPEAT-CONTAINING
PROTEIN 20
(Homo
sapiens) 		4 / 7 TYR C  74
VAL C  69
VAL C  50
GLY C 553
 None
 1.14A 3kmoB-5k1cC:
undetectable		 3kmoB-5k1cC:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 5k1c WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		5 / 12 LEU B 143
SER B 134
ILE B 183
LEU B 164
ASP B 138
 None
 1.12A 3ko0A-5k1cB:
undetectable
3ko0B-5k1cB:
undetectable
3ko0C-5k1cB:
undetectable
3ko0D-5k1cB:
undetectable		 3ko0A-5k1cB:
9.96
3ko0B-5k1cB:
9.96
3ko0C-5k1cB:
9.96
3ko0D-5k1cB:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)		 5k1c WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		5 / 11 ASP B 138
LEU B 164
LEU B 143
SER B 134
ILE B 183
 None
 1.13A 3ko0A-5k1cB:
undetectable
3ko0B-5k1cB:
undetectable
3ko0I-5k1cB:
undetectable
3ko0J-5k1cB:
undetectable		 3ko0A-5k1cB:
9.96
3ko0B-5k1cB:
9.96
3ko0I-5k1cB:
9.96
3ko0J-5k1cB:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 5k1c WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		5 / 12 LEU B 143
SER B 134
ILE B 183
LEU B 164
ASP B 138
 None
 1.08A 3ko0K-5k1cB:
undetectable
3ko0L-5k1cB:
undetectable
3ko0S-5k1cB:
undetectable
3ko0T-5k1cB:
undetectable		 3ko0K-5k1cB:
9.96
3ko0L-5k1cB:
9.96
3ko0S-5k1cB:
9.96
3ko0T-5k1cB:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 5k1c WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		5 / 12 LEU B 164
LEU B 143
SER B 134
ILE B 183
ASP B 138
 None
 1.12A 3ko0K-5k1cB:
undetectable
3ko0L-5k1cB:
undetectable
3ko0M-5k1cB:
undetectable
3ko0N-5k1cB:
undetectable		 3ko0K-5k1cB:
9.96
3ko0L-5k1cB:
9.96
3ko0M-5k1cB:
9.96
3ko0N-5k1cB:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 5k1c WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		5 / 12 LEU B 143
SER B 134
ILE B 183
LEU B 164
ASP B 138
 None
 1.08A 3ko0M-5k1cB:
undetectable
3ko0N-5k1cB:
undetectable
3ko0O-5k1cB:
undetectable
3ko0P-5k1cB:
undetectable		 3ko0M-5k1cB:
9.96
3ko0N-5k1cB:
9.96
3ko0O-5k1cB:
9.96
3ko0P-5k1cB:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)		 5k1c WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		5 / 12 ASP B 138
LEU B 164
LEU B 143
SER B 134
ILE B 183
 None
 1.10A 3ko0M-5k1cB:
undetectable
3ko0N-5k1cB:
undetectable
3ko0O-5k1cB:
undetectable
3ko0P-5k1cB:
undetectable		 3ko0M-5k1cB:
9.96
3ko0N-5k1cB:
9.96
3ko0O-5k1cB:
9.96
3ko0P-5k1cB:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5k1c UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 12
WD REPEAT-CONTAINING
PROTEIN 20
(Homo
sapiens;
Homo
sapiens) 		4 / 4 GLY C 263
GLU A 283
ASP C 241
ASP C 283
 None
 1.18A 3mb5A-5k1cC:
undetectable		 3mb5A-5k1cC:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 5k1c WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		4 / 7 GLU B 189
SER B 187
VAL B 191
VAL B 213
 None
 1.27A 3n61A-5k1cB:
undetectable
3n61B-5k1cB:
undetectable		 3n61A-5k1cB:
20.93
3n61B-5k1cB:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 5k1c WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		5 / 10 LEU B 226
ALA B 215
GLY B 254
VAL B 267
LEU B 258
 None
 1.00A 3ogpA-5k1cB:
undetectable		 3ogpA-5k1cB:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5k1c UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 12
(Homo
sapiens) 		3 / 3 HIS A 243
SER A 227
GLU A 241
 None
 0.82A 3s8pA-5k1cA:
undetectable		 3s8pA-5k1cA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 5k1c WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		6 / 12 ILE B 375
THR B 377
THR B 430
GLY B 427
ILE B 431
VAL B  20
 None
 1.42A 4c9lA-5k1cB:
undetectable		 4c9lA-5k1cB:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 5k1c WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		6 / 12 ILE B 375
THR B 377
THR B 430
GLY B 427
ILE B 431
VAL B  20
 None
 1.43A 4c9lB-5k1cB:
undetectable		 4c9lB-5k1cB:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 5k1c WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		6 / 12 ILE B 375
THR B 377
THR B 430
GLY B 427
ILE B 431
VAL B  20
 None
 1.42A 4c9oA-5k1cB:
undetectable		 4c9oA-5k1cB:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 5k1c WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		6 / 12 ILE B 375
THR B 377
THR B 430
GLY B 427
ILE B 431
VAL B  20
 None
 1.44A 4c9oB-5k1cB:
undetectable		 4c9oB-5k1cB:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_B_CLQB303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5k1c WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		5 / 11 HIS B 374
PHE B 507
GLY B 463
GLY B 464
ASN B 504
 None
 1.45A 4fglA-5k1cB:
undetectable
4fglB-5k1cB:
undetectable		 4fglA-5k1cB:
17.96
4fglB-5k1cB:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		 5k1c WD REPEAT-CONTAINING
PROTEIN 20
(Homo
sapiens) 		5 / 9 ASP C 382
VAL C 288
ALA C 298
GLY C 370
GLY C 300
 None
 1.29A 4mm5A-5k1cC:
undetectable		 4mm5A-5k1cC:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		 5k1c WD REPEAT-CONTAINING
PROTEIN 20
(Homo
sapiens) 		5 / 9 ASP C 382
VAL C 288
ALA C 298
GLY C 370
GLY C 300
 None
 1.28A 4mmbA-5k1cC:
undetectable		 4mmbA-5k1cC:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 5k1c WD REPEAT-CONTAINING
PROTEIN 20
(Homo
sapiens) 		5 / 9 ASP C 382
VAL C 288
ALA C 298
GLY C 370
GLY C 300
 None
 1.33A 4mmeA-5k1cC:
undetectable		 4mmeA-5k1cC:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		 5k1c WD REPEAT-CONTAINING
PROTEIN 20
(Homo
sapiens) 		5 / 9 ASP C 382
VAL C 288
ALA C 298
GLY C 370
GLY C 300
 None
 1.33A 4mmeB-5k1cC:
undetectable		 4mmeB-5k1cC:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		 5k1c WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		3 / 3 ARG B 476
TRP B 474
ILE B 551
 None
 1.09A 4mwxA-5k1cB:
7.1		 4mwxA-5k1cB:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5k1c WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		5 / 10 THR B 115
ILE B 141
LEU B 149
VAL B  82
LEU B 123
 None
 1.49A 4r3aB-5k1cB:
undetectable		 4r3aB-5k1cB:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 5k1c WD REPEAT-CONTAINING
PROTEIN 20
(Homo
sapiens) 		5 / 12 HIS C 303
LEU C 536
THR C 548
LEU C 526
THR C  19
 None
 1.17A 5byjA-5k1cC:
undetectable		 5byjA-5k1cC:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5k1c WD REPEAT-CONTAINING
PROTEIN 20
(Homo
sapiens) 		5 / 12 THR C 217
CYH C 237
ALA C 222
ALA C 168
THR C 153
 None
 1.22A 5d0xH-5k1cC:
undetectable
5d0xI-5k1cC:
undetectable		 5d0xH-5k1cC:
16.70
5d0xI-5k1cC:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 5k1c WD REPEAT-CONTAINING
PROTEIN 20
(Homo
sapiens) 		3 / 3 GLY C 263
GLN C 240
LYS C 259
 None
 0.90A 5imsB-5k1cC:
undetectable		 5imsB-5k1cC:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5k1c UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 12
(Homo
sapiens) 		5 / 11 ILE A 254
GLN A 177
LEU A 200
VAL A 303
LEU A  57
 None
 1.20A 5ji0A-5k1cA:
undetectable		 5ji0A-5k1cA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5k1c WD REPEAT-CONTAINING
PROTEIN 20
(Homo
sapiens) 		5 / 12 THR C 217
CYH C 237
ALA C 222
ALA C 168
THR C 153
 None
 1.19A 5l5zH-5k1cC:
undetectable
5l5zI-5k1cC:
undetectable		 5l5zH-5k1cC:
16.70
5l5zI-5k1cC:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5k1c WD REPEAT-CONTAINING
PROTEIN 20
(Homo
sapiens) 		5 / 12 THR C 217
CYH C 237
ALA C 222
ALA C 168
THR C 153
 None
 1.19A 5l5zV-5k1cC:
undetectable
5l5zW-5k1cC:
undetectable		 5l5zV-5k1cC:
16.70
5l5zW-5k1cC:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_1
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 5k1c UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 12
(Homo
sapiens) 		4 / 5 GLY A 178
ARG A 298
ASP A 198
GLN A 141
 None
 1.44A 5ubbA-5k1cA:
undetectable		 5ubbA-5k1cA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 5k1c UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 12
WD REPEAT-CONTAINING
PROTEIN 20
(Homo
sapiens) 		4 / 6 ARG A 298
PHE C 262
ILE A 212
THR A 213
 None
 0.98A 5vceA-5k1cA:
undetectable		 5vceA-5k1cA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_2
(RIBOFLAVIN LYASE)		 5k1c WD REPEAT-CONTAINING
PROTEIN 20
(Homo
sapiens) 		4 / 5 GLN C 240
ASP C 241
SER C 239
ARG C 245
 None
 1.45A 5w4zA-5k1cC:
undetectable		 5w4zA-5k1cC:
8.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 5k1c UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 12
(Homo
sapiens) 		4 / 8 GLY A  40
LEU A  41
ASN A  51
ALA A 320
 None
 0.35A 5xu8A-5k1cA:
31.6		 5xu8A-5k1cA:
30.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 5k1c UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 12
(Homo
sapiens) 		4 / 8 GLY A  40
LEU A  41
SER A  52
ALA A 320
 None
 0.73A 5xu8A-5k1cA:
31.6		 5xu8A-5k1cA:
30.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 5k1c UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 12
(Homo
sapiens) 		4 / 8 LEU A  41
ASN A  51
ALA A 320
PHE A 331
 None
 0.52A 5xu8A-5k1cA:
31.6		 5xu8A-5k1cA:
30.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 5k1c UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 12
(Homo
sapiens) 		4 / 8 LEU A  41
SER A  52
ALA A 320
PHE A 331
 None
 0.81A 5xu8A-5k1cA:
31.6		 5xu8A-5k1cA:
30.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)		 5k1c WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		5 / 10 LEU B 429
ILE B 368
LEU B 369
LEU B 398
ALA B 385
 None
 1.18A 5y7pD-5k1cB:
undetectable		 5y7pD-5k1cB:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 5k1c WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		5 / 10 LEU B 429
ILE B 368
LEU B 369
LEU B 398
ALA B 385
 None
 1.21A 5y7pH-5k1cB:
undetectable		 5y7pH-5k1cB:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 5k1c WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens) 		4 / 8 GLU B  72
ARG B 531
THR B 513
PRO B 514
 None
 1.01A 6a4iA-5k1cB:
undetectable		 6a4iA-5k1cB:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 5k1c WD REPEAT-CONTAINING
PROTEIN 20
(Homo
sapiens) 		5 / 9 VAL C 152
GLY C 125
ILE C 130
LEU C 129
ASP C 105
 None
 1.50A 6c2mC-5k1cC:
undetectable		 6c2mC-5k1cC:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 5k1c UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 12
(Homo
sapiens) 		5 / 12 THR A 135
LEU A  54
PHE A 128
PHE A  63
VAL A  67
 None
 1.13A 6drzA-5k1cA:
undetectable		 6drzA-5k1cA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 5k1c UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 12
(Homo
sapiens) 		4 / 5 ASN A  43
GLY A 310
HIS A 317
ASP A 332
 None
 0.57A 6gh9A-5k1cA:
28.0		 6gh9A-5k1cA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5k1c UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 12
WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens;
Homo
sapiens) 		4 / 8 ASP B  76
HIS B 116
ASP B 118
GLU A 241
 None
 1.23A 6mn4A-5k1cB:
undetectable		 6mn4A-5k1cB:
18.46