SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5k1h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5k1h EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Homo
sapiens) 		5 / 10 PHE B 509
LEU B 528
VAL B 526
PHE B 494
VAL B 492
 None
 1.40A 1q23E-5k1hB:
undetectable		 1q23E-5k1hB:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5k1h EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Homo
sapiens) 		5 / 10 PHE B 509
LEU B 528
VAL B 526
PHE B 494
VAL B 492
 None
 1.48A 1q23K-5k1hB:
undetectable		 1q23K-5k1hB:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5k1h EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Homo
sapiens) 		5 / 12 THR B 571
PHE B 525
ASP B 542
VAL B 541
ALA B 529
 None
 1.36A 2g72A-5k1hB:
undetectable		 2g72A-5k1hB:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GEH_A_NHYA300_1
(CARBONIC ANHYDRASE 2)		 5k1h EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Homo
sapiens) 		4 / 8 HIS B 496
VAL B 541
VAL B 526
TRP B 519
 None
 0.92A 2gehA-5k1hB:
undetectable		 2gehA-5k1hB:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 5k1h EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Homo
sapiens) 		4 / 6 LEU B 346
ILE B 370
ARG B 395
PRO B 387
 None
 1.17A 2ygoA-5k1hB:
undetectable		 2ygoA-5k1hB:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 5k1h EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Homo
sapiens) 		4 / 8 ILE B 312
TYR B 251
GLN B 272
LEU B 313
 None
 0.84A 3ozwA-5k1hB:
undetectable		 3ozwA-5k1hB:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWX_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5k1h EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Homo
sapiens) 		4 / 7 TRP B 607
TRP B 562
GLU B 561
VAL B 570
 None
 1.41A 4cwxA-5k1hB:
undetectable
4cwxB-5k1hB:
undetectable		 4cwxA-5k1hB:
22.41
4cwxB-5k1hB:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWY_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5k1h EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Homo
sapiens) 		4 / 7 VAL B 570
TRP B 607
TRP B 562
GLU B 561
 None
 1.41A 4cwyA-5k1hB:
undetectable
4cwyB-5k1hB:
undetectable		 4cwyA-5k1hB:
22.41
4cwyB-5k1hB:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWY_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5k1h EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Homo
sapiens) 		4 / 7 TRP B 607
TRP B 562
GLU B 561
VAL B 570
 None
 1.42A 4cwyA-5k1hB:
undetectable
4cwyB-5k1hB:
undetectable		 4cwyA-5k1hB:
22.41
4cwyB-5k1hB:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)		 5k1h EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Homo
sapiens) 		4 / 5 GLU B 448
VAL B 431
LEU B 412
VAL B 415
 None
 1.03A 4lb0B-5k1hB:
undetectable		 4lb0B-5k1hB:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)		 5k1h EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Homo
sapiens) 		3 / 3 ASP B 600
GLY B 216
ASP B 217
 None
 0.65A 4xdtA-5k1hB:
undetectable		 4xdtA-5k1hB:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 5k1h EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Homo
sapiens) 		3 / 3 HIS B 554
GLU B 553
TRP B 585
 None
 0.93A 5odqD-5k1hB:
undetectable		 5odqD-5k1hB:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODR_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 5k1h EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Homo
sapiens) 		3 / 3 HIS B 554
GLU B 553
TRP B 585
 None
 0.91A 5odrD-5k1hB:
undetectable		 5odrD-5k1hB:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO9_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5k1h EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Homo
sapiens) 		4 / 7 TRP B 607
TRP B 562
GLU B 561
VAL B 570
 None
 1.38A 5uo9A-5k1hB:
undetectable
5uo9B-5k1hB:
undetectable		 5uo9A-5k1hB:
20.00
5uo9B-5k1hB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO9_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5k1h EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Homo
sapiens) 		4 / 7 TRP B 607
TRP B 562
GLU B 561
VAL B 570
 None
 1.35A 5uo9C-5k1hB:
undetectable
5uo9D-5k1hB:
undetectable		 5uo9C-5k1hB:
20.00
5uo9D-5k1hB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV9_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5k1h EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Homo
sapiens) 		4 / 7 VAL B 570
TRP B 607
TRP B 562
GLU B 561
 None
 1.31A 5vv9A-5k1hB:
undetectable
5vv9B-5k1hB:
undetectable		 5vv9A-5k1hB:
22.41
5vv9B-5k1hB:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVA_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5k1h EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Homo
sapiens) 		4 / 7 VAL B 570
TRP B 607
TRP B 562
GLU B 561
 None
 1.32A 5vvaA-5k1hB:
undetectable
5vvaB-5k1hB:
undetectable		 5vvaA-5k1hB:
22.41
5vvaB-5k1hB:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB503_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5k1h EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Homo
sapiens) 		4 / 7 TRP B 607
TRP B 562
GLU B 561
VAL B 570
 None
 1.33A 6av6A-5k1hB:
undetectable
6av6B-5k1hB:
undetectable		 6av6A-5k1hB:
8.87
6av6B-5k1hB:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIE_B_H4BB502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5k1h EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Homo
sapiens) 		4 / 7 TRP B 607
TRP B 562
GLU B 561
VAL B 570
 None
 1.31A 6cieA-5k1hB:
undetectable
6cieB-5k1hB:
undetectable		 6cieA-5k1hB:
8.87
6cieB-5k1hB:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIF_C_H4BC502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5k1h EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Homo
sapiens) 		4 / 7 VAL B 570
TRP B 607
TRP B 562
GLU B 561
 None
 1.34A 6cifC-5k1hB:
undetectable
6cifD-5k1hB:
undetectable		 6cifC-5k1hB:
8.87
6cifD-5k1hB:
8.87