SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5k1r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 5k1r BURKHOLDERIA
PSEUDOMALLEI
SPHINGOSINE-1-PHOSPH
ATE LYASE BPSS2021
(Burkholderia
pseudomallei) 		5 / 12 ILE A 213
LEU A 219
ASP A 233
GLY A 234
ALA A 158
 None
None
PLP  A 501 (-2.6A)
None
None
 1.07A 1axwA-5k1rA:
undetectable		 1axwA-5k1rA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IA0_B_TXLB502_1
(TUBULIN BETA CHAIN)		 5k1r BURKHOLDERIA
PSEUDOMALLEI
SPHINGOSINE-1-PHOSPH
ATE LYASE BPSS2021
(Burkholderia
pseudomallei) 		5 / 12 VAL A 109
ASP A 113
LEU A 282
PHE A 289
GLY A 261
 None
 1.50A 1ia0B-5k1rA:
undetectable		 1ia0B-5k1rA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_C_DEXC3999_1
(GLUCOCORTICOID
RECEPTOR)		 5k1r BURKHOLDERIA
PSEUDOMALLEI
SPHINGOSINE-1-PHOSPH
ATE LYASE BPSS2021
(Burkholderia
pseudomallei) 		5 / 12 MET A 402
ASN A 392
GLY A 393
GLN A 408
THR A  56
 None
 1.49A 1p93C-5k1rA:
undetectable		 1p93C-5k1rA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUB_B_TXLB501_1
(TUBULIN)		 5k1r BURKHOLDERIA
PSEUDOMALLEI
SPHINGOSINE-1-PHOSPH
ATE LYASE BPSS2021
(Burkholderia
pseudomallei) 		5 / 12 VAL A 109
ASP A 113
LEU A 282
PHE A 289
GLY A 261
 None
 1.50A 1tubB-5k1rA:
undetectable		 1tubB-5k1rA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACK_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 5k1r BURKHOLDERIA
PSEUDOMALLEI
SPHINGOSINE-1-PHOSPH
ATE LYASE BPSS2021
(Burkholderia
pseudomallei) 		4 / 7 GLY A 234
SER A 266
PHE A 162
HIS A 231
 None
 1.02A 2ackA-5k1rA:
undetectable		 2ackA-5k1rA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 5k1r BURKHOLDERIA
PSEUDOMALLEI
SPHINGOSINE-1-PHOSPH
ATE LYASE BPSS2021
(Burkholderia
pseudomallei) 		6 / 12 ILE A 222
ALA A 221
GLY A 217
ASP A 186
VAL A 185
VAL A 232
 None
 1.17A 2qe6A-5k1rA:
undetectable		 2qe6A-5k1rA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 5k1r BURKHOLDERIA
PSEUDOMALLEI
SPHINGOSINE-1-PHOSPH
ATE LYASE BPSS2021
(Burkholderia
pseudomallei) 		6 / 12 ILE A 222
ALA A 221
GLY A 217
ASP A 186
VAL A 185
VAL A 232
 None
 1.20A 2qe6B-5k1rA:
undetectable		 2qe6B-5k1rA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5k1r BURKHOLDERIA
PSEUDOMALLEI
SPHINGOSINE-1-PHOSPH
ATE LYASE BPSS2021
(Burkholderia
pseudomallei) 		4 / 8 ILE A 252
PHE A 342
GLY A 238
GLY A 237
 None
 0.77A 2qx4A-5k1rA:
2.1
2qx4B-5k1rA:
undetectable		 2qx4A-5k1rA:
19.14
2qx4B-5k1rA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5k1r BURKHOLDERIA
PSEUDOMALLEI
SPHINGOSINE-1-PHOSPH
ATE LYASE BPSS2021
(Burkholderia
pseudomallei) 		4 / 6 ILE A 252
PHE A 342
GLY A 238
GLY A 237
 None
 0.76A 2qx6A-5k1rA:
2.7
2qx6B-5k1rA:
undetectable		 2qx6A-5k1rA:
19.14
2qx6B-5k1rA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_1
(HYPOTHETICAL PROTEIN
TTHA0223)		 5k1r BURKHOLDERIA
PSEUDOMALLEI
SPHINGOSINE-1-PHOSPH
ATE LYASE BPSS2021
(Burkholderia
pseudomallei) 		4 / 5 TYR A 294
GLU A  93
ARG A 290
ASP A  84
 None
 1.47A 2yqzB-5k1rA:
3.5		 2yqzB-5k1rA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P73_A_ACTA275_0
(MHC RFP-Y CLASS I
ALPHA CHAIN)		 5k1r BURKHOLDERIA
PSEUDOMALLEI
SPHINGOSINE-1-PHOSPH
ATE LYASE BPSS2021
(Burkholderia
pseudomallei) 		3 / 3 ILE A 355
VAL A 425
ARG A 429
 None
 0.74A 3p73A-5k1rA:
undetectable		 3p73A-5k1rA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 5k1r BURKHOLDERIA
PSEUDOMALLEI
SPHINGOSINE-1-PHOSPH
ATE LYASE BPSS2021
(Burkholderia
pseudomallei) 		5 / 11 ILE A 213
LEU A 219
ASP A 233
GLY A 234
ALA A 158
 None
None
PLP  A 501 (-2.6A)
None
None
 1.08A 4fogD-5k1rA:
undetectable		 4fogD-5k1rA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5k1r BURKHOLDERIA
PSEUDOMALLEI
SPHINGOSINE-1-PHOSPH
ATE LYASE BPSS2021
(Burkholderia
pseudomallei) 		4 / 5 HIS A 401
TYR A  58
GLY A  55
SER A  54
 None
 1.30A 4fu8A-5k1rA:
undetectable		 4fu8A-5k1rA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 5k1r BURKHOLDERIA
PSEUDOMALLEI
SPHINGOSINE-1-PHOSPH
ATE LYASE BPSS2021
(Burkholderia
pseudomallei) 		4 / 6 ASP A 233
ASP A 268
ALA A 161
PHE A 162
 PLP  A 501 (-2.6A)
PLP  A 501 (-3.6A)
PLP  A 501 ( 4.4A)
None
 1.20A 4nedA-5k1rA:
1.2		 4nedA-5k1rA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 5k1r BURKHOLDERIA
PSEUDOMALLEI
SPHINGOSINE-1-PHOSPH
ATE LYASE BPSS2021
(Burkholderia
pseudomallei) 		4 / 6 ASP A 233
ASP A 268
SER A 123
PHE A 162
 PLP  A 501 (-2.6A)
PLP  A 501 (-3.6A)
None
None
 1.20A 4nedA-5k1rA:
1.2		 4nedA-5k1rA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5k1r BURKHOLDERIA
PSEUDOMALLEI
SPHINGOSINE-1-PHOSPH
ATE LYASE BPSS2021
(Burkholderia
pseudomallei) 		4 / 6 GLY A 237
PHE A 342
ILE A 252
PHE A 346
 None
 1.02A 4qogA-5k1rA:
undetectable
4qogB-5k1rA:
undetectable		 4qogA-5k1rA:
19.34
4qogB-5k1rA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 5k1r BURKHOLDERIA
PSEUDOMALLEI
SPHINGOSINE-1-PHOSPH
ATE LYASE BPSS2021
(Burkholderia
pseudomallei) 		5 / 12 ALA A 338
GLY A 244
ILE A 265
ALA A 267
GLY A 237
 None
 1.11A 4r29D-5k1rA:
undetectable		 4r29D-5k1rA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 5k1r BURKHOLDERIA
PSEUDOMALLEI
SPHINGOSINE-1-PHOSPH
ATE LYASE BPSS2021
(Burkholderia
pseudomallei) 		6 / 12 PHE A 162
VAL A 185
ASP A 214
GLY A 203
ILE A 153
VAL A 173
 None
 1.50A 4xdrA-5k1rA:
undetectable		 4xdrA-5k1rA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5k1r BURKHOLDERIA
PSEUDOMALLEI
SPHINGOSINE-1-PHOSPH
ATE LYASE BPSS2021
(Burkholderia
pseudomallei) 		5 / 12 ALA A 267
GLY A 273
SER A 280
GLY A 279
LEU A 329
 None
 0.84A 5c0oH-5k1rA:
undetectable		 5c0oH-5k1rA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 5k1r BURKHOLDERIA
PSEUDOMALLEI
SPHINGOSINE-1-PHOSPH
ATE LYASE BPSS2021
(Burkholderia
pseudomallei) 		3 / 3 THR A 409
THR A 344
PHE A 366
 None
 0.75A 5cxvA-5k1rA:
undetectable		 5cxvA-5k1rA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 5k1r BURKHOLDERIA
PSEUDOMALLEI
SPHINGOSINE-1-PHOSPH
ATE LYASE BPSS2021
(Burkholderia
pseudomallei) 		5 / 12 PRO A 276
ILE A 319
GLY A 316
ARG A 314
ALA A  71
 None
 1.15A 5h5fA-5k1rA:
undetectable		 5h5fA-5k1rA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 5k1r BURKHOLDERIA
PSEUDOMALLEI
SPHINGOSINE-1-PHOSPH
ATE LYASE BPSS2021
(Burkholderia
pseudomallei) 		4 / 8 LEU A 358
PHE A 370
ALA A 424
PRO A 397
 None
 0.85A 5m0oC-5k1rA:
undetectable		 5m0oC-5k1rA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5k1r BURKHOLDERIA
PSEUDOMALLEI
SPHINGOSINE-1-PHOSPH
ATE LYASE BPSS2021
(Burkholderia
pseudomallei) 		3 / 3 SER A 266
SER A 280
PHE A 162
 None
 0.84A 5mugA-5k1rA:
undetectable		 5mugA-5k1rA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5k1r BURKHOLDERIA
PSEUDOMALLEI
SPHINGOSINE-1-PHOSPH
ATE LYASE BPSS2021
(Burkholderia
pseudomallei) 		5 / 12 LEU A 236
GLY A 234
TYR A 274
GLY A 238
GLY A 237
 PLP  A 501 (-3.6A)
None
None
None
None
 0.83A 5wyqB-5k1rA:
undetectable		 5wyqB-5k1rA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5k1r BURKHOLDERIA
PSEUDOMALLEI
SPHINGOSINE-1-PHOSPH
ATE LYASE BPSS2021
(Burkholderia
pseudomallei) 		3 / 3 SER A  54
HIS A 401
TYR A 208
 None
None
PLP  A 501 ( 4.5A)
 0.77A 5y2tA-5k1rA:
undetectable		 5y2tA-5k1rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5k1r BURKHOLDERIA
PSEUDOMALLEI
SPHINGOSINE-1-PHOSPH
ATE LYASE BPSS2021
(Burkholderia
pseudomallei) 		5 / 10 GLY A 309
ARG A 290
ALA A 121
LEU A 282
PHE A 366
 None
 1.45A 5zjiA-5k1rA:
undetectable
5zjiJ-5k1rA:
undetectable		 5zjiA-5k1rA:
7.89
5zjiJ-5k1rA:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 5k1r BURKHOLDERIA
PSEUDOMALLEI
SPHINGOSINE-1-PHOSPH
ATE LYASE BPSS2021
(Burkholderia
pseudomallei) 		5 / 12 PRO A 155
PHE A 162
VAL A 194
PHE A 289
ILE A 222
 None
 1.35A 6becA-5k1rA:
undetectable
6becB-5k1rA:
undetectable
6becC-5k1rA:
undetectable		 6becA-5k1rA:
18.09
6becB-5k1rA:
18.09
6becC-5k1rA:
18.09