SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5k1s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5k1s OXIDOREDUCTASE,
ZINC-BINDING
DEHYDROGENASE FAMILY
(Myxococcus
xanthus) 		4 / 8 THR A 292
GLY A 152
LEU A  87
GLY A 133
 None
 0.75A 1d0vA-5k1sA:
3.2		 1d0vA-5k1sA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5k1s OXIDOREDUCTASE,
ZINC-BINDING
DEHYDROGENASE FAMILY
(Myxococcus
xanthus) 		5 / 9 SER A  91
GLY A  93
ARG A  99
ALA A  96
GLY A 101
 ZN  A 401 ( 4.2A)
ZN  A 401 (-4.5A)
None
None
None
 1.18A 1jb0A-5k1sA:
undetectable		 1jb0A-5k1sA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5k1s OXIDOREDUCTASE,
ZINC-BINDING
DEHYDROGENASE FAMILY
(Myxococcus
xanthus) 		4 / 8 THR A 292
GLY A 152
LEU A  87
GLY A 133
 None
 0.76A 1jhaA-5k1sA:
3.6		 1jhaA-5k1sA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 5k1s OXIDOREDUCTASE,
ZINC-BINDING
DEHYDROGENASE FAMILY
(Myxococcus
xanthus) 		5 / 11 SER A 183
SER A 182
GLY A 308
THR A 304
GLN A 311
 None
 1.45A 1jr1A-5k1sA:
undetectable		 1jr1A-5k1sA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 5k1s OXIDOREDUCTASE,
ZINC-BINDING
DEHYDROGENASE FAMILY
(Myxococcus
xanthus) 		4 / 7 LEU A 117
ILE A  69
GLN A  -2
MET A   1
 None
 1.05A 1kglA-5k1sA:
undetectable		 1kglA-5k1sA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 5k1s OXIDOREDUCTASE,
ZINC-BINDING
DEHYDROGENASE FAMILY
(Myxococcus
xanthus) 		4 / 7 PRO A 128
GLY A 120
LEU A 117
PRO A  23
 None
 0.90A 1ya4B-5k1sA:
undetectable		 1ya4B-5k1sA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_B_IBPB2002_1
(SERUM ALBUMIN)		 5k1s OXIDOREDUCTASE,
ZINC-BINDING
DEHYDROGENASE FAMILY
(Myxococcus
xanthus) 		5 / 10 ALA A 175
LEU A 181
LEU A 207
ALA A 210
VAL A 215
 None
 1.04A 2bxgB-5k1sA:
undetectable		 2bxgB-5k1sA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 5k1s OXIDOREDUCTASE,
ZINC-BINDING
DEHYDROGENASE FAMILY
(Myxococcus
xanthus) 		4 / 5 LEU A 207
PHE A 312
VAL A 184
ALA A 175
 None
 1.07A 2cizA-5k1sA:
undetectable		 2cizA-5k1sA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5k1s OXIDOREDUCTASE,
ZINC-BINDING
DEHYDROGENASE FAMILY
(Myxococcus
xanthus) 		4 / 7 ARG A 193
GLU A 168
ALA A 234
ALA A 256
 None
 1.04A 2ejfA-5k1sA:
undetectable		 2ejfA-5k1sA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_D_CHDD702_0
(FERROCHELATASE)		 5k1s OXIDOREDUCTASE,
ZINC-BINDING
DEHYDROGENASE FAMILY
(Myxococcus
xanthus) 		3 / 3 ARG A  24
GLY A  72
PRO A  73
 None
 0.76A 2hreD-5k1sA:
undetectable		 2hreD-5k1sA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_1
(PHOSPHOLIPASE A2)		 5k1s OXIDOREDUCTASE,
ZINC-BINDING
DEHYDROGENASE FAMILY
(Myxococcus
xanthus) 		4 / 5 VAL A 261
VAL A 238
THR A 247
ARG A 260
 None
 1.16A 3bjwA-5k1sA:
undetectable		 3bjwA-5k1sA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_1
(PHOSPHOLIPASE A2)		 5k1s OXIDOREDUCTASE,
ZINC-BINDING
DEHYDROGENASE FAMILY
(Myxococcus
xanthus) 		4 / 5 VAL A 261
VAL A 238
THR A 247
ARG A 260
 None
 1.16A 3bjwC-5k1sA:
undetectable		 3bjwC-5k1sA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5k1s OXIDOREDUCTASE,
ZINC-BINDING
DEHYDROGENASE FAMILY
(Myxococcus
xanthus) 		3 / 3 GLY A 120
GLY A 114
GLY A  61
 None
 0.41A 3bogC-5k1sA:
undetectable		 3bogC-5k1sA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5k1s OXIDOREDUCTASE,
ZINC-BINDING
DEHYDROGENASE FAMILY
(Myxococcus
xanthus) 		5 / 12 LEU A 181
GLU A 241
GLY A 177
SER A 176
ALA A 239
 None
 1.13A 3ou6C-5k1sA:
6.8		 3ou6C-5k1sA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_A_PQNA847_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5k1s OXIDOREDUCTASE,
ZINC-BINDING
DEHYDROGENASE FAMILY
(Myxococcus
xanthus) 		5 / 9 SER A  91
GLY A  93
ARG A  99
ALA A  96
GLY A 101
 ZN  A 401 ( 4.2A)
ZN  A 401 (-4.5A)
None
None
None
 1.19A 3pcqA-5k1sA:
undetectable		 3pcqA-5k1sA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5k1s OXIDOREDUCTASE,
ZINC-BINDING
DEHYDROGENASE FAMILY
(Myxococcus
xanthus) 		4 / 7 GLY A 174
THR A 173
ILE A 172
THR A 153
 None
 0.75A 4acaC-5k1sA:
2.7		 4acaC-5k1sA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5k1s OXIDOREDUCTASE,
ZINC-BINDING
DEHYDROGENASE FAMILY
(Myxococcus
xanthus) 		4 / 5 GLY A 114
GLY A 119
MET A 125
GLU A 115
 None
 1.26A 4fglC-5k1sA:
3.7		 4fglC-5k1sA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 5k1s OXIDOREDUCTASE,
ZINC-BINDING
DEHYDROGENASE FAMILY
(Myxococcus
xanthus) 		5 / 11 THR A 160
ALA A 300
GLY A 152
THR A 153
ALA A 154
 None
 1.08A 4qvyH-5k1sA:
undetectable		 4qvyH-5k1sA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_A_ADNA301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 5k1s OXIDOREDUCTASE,
ZINC-BINDING
DEHYDROGENASE FAMILY
(Myxococcus
xanthus) 		5 / 9 GLY A 220
ILE A 242
SER A 176
VAL A 197
THR A 173
 None
 1.43A 4x3mA-5k1sA:
2.3		 4x3mA-5k1sA:
26.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5k1s OXIDOREDUCTASE,
ZINC-BINDING
DEHYDROGENASE FAMILY
(Myxococcus
xanthus) 		5 / 11 THR A 160
ALA A 300
GLY A 152
THR A 153
ALA A 154
 None
 1.08A 5bxnV-5k1sA:
undetectable
5bxnW-5k1sA:
undetectable		 5bxnV-5k1sA:
20.87
5bxnW-5k1sA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 5k1s OXIDOREDUCTASE,
ZINC-BINDING
DEHYDROGENASE FAMILY
(Myxococcus
xanthus) 		4 / 8 LEU A 117
ILE A  69
GLN A  -2
MET A   1
 None
 1.01A 5ljbA-5k1sA:
undetectable		 5ljbA-5k1sA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5k1s OXIDOREDUCTASE,
ZINC-BINDING
DEHYDROGENASE FAMILY
(Myxococcus
xanthus) 		3 / 3 ASN A 331
VAL A  39
HIS A 326
 None
 0.85A 6a5yD-5k1sA:
undetectable		 6a5yD-5k1sA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 5k1s OXIDOREDUCTASE,
ZINC-BINDING
DEHYDROGENASE FAMILY
(Myxococcus
xanthus) 		5 / 9 HIS A   0
LEU A  60
ALA A  58
VAL A  56
SER A  55
 None
 1.30A 6c2mB-5k1sA:
undetectable		 6c2mB-5k1sA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA204_0
(N-ACETYLTRANSFERASE)		 5k1s OXIDOREDUCTASE,
ZINC-BINDING
DEHYDROGENASE FAMILY
(Myxococcus
xanthus) 		4 / 5 THR A 292
CYH A 149
THR A 150
GLY A 152
 None
ZN  A 402 (-2.3A)
None
None
 1.26A 6gtqA-5k1sA:
undetectable		 6gtqA-5k1sA:
18.08