SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5k22'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JOM_A_FFOA161_0 (DIHYDROFOLATE REDUCTASE)	5k22	PROTEIN TYROSINE PHOSPHATASE TYPE IVA 2 (Homo sapiens)	5 / 11	LEU A 27 PHE A 30 ILE A 60 LEU A 34 THR A 49	None	1.23A	1jomA-5k22A: 2.3	1jomA-5k22A: 26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2G72_B_SAMB2002_0 (PHENYLETHANOLAMINE N-METHYLTRANSFERASE)	5k22	PROTEIN TYROSINE PHOSPHATASE TYPE IVA 2 (Homo sapiens)	5 / 12	LEU A 84 ILE A 77 VAL A 45 ALA A 113 VAL A 99	None	1.23A	2g72B-5k22A: undetectable	2g72B-5k22A: 21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DC3_A_ADNA401_2 (ADENOSINE KINASE)	5k22	PROTEIN TYROSINE PHOSPHATASE TYPE IVA 2 (Homo sapiens)	4 / 4	LEU A 105 ILE A 130 GLY A 106 PHE A 138	None	1.03A	4dc3A-5k22A: undetectable	4dc3A-5k22A: 22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EJG_C_NCTC501_1 (CYTOCHROME P450 2A13)	5k22	PROTEIN TYROSINE PHOSPHATASE TYPE IVA 2 (Homo sapiens)	4 / 7	PHE A 16 ALA A 119 LEU A 82 LEU A 85	None	0.93A	4ejgC-5k22A: undetectable	4ejgC-5k22A: 16.42

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1JOM_A_FFOA161_0","DIHYDROFOLATE REDUCTASE","5k22","PROTEIN TYROSINE PHOSPHATASE TYPE IVA 2","Homo sapiens",5,"LEU A  27;PHE A  30;ILE A  60;LEU A  34;THR A  49","None","1.23A","1jomA-5k22A:2.3","1jomA-5k22A:26.32"],["2G72_B_SAMB2002_0","PHENYLETHANOLAMINE N-METHYLTRANSFERASE","5k22","PROTEIN TYROSINE PHOSPHATASE TYPE IVA 2","Homo sapiens",5,"LEU A  84;ILE A  77;VAL A  45;ALA A 113;VAL A  99","None","1.23A","2g72B-5k22A:undetectable","2g72B-5k22A:21.62"],["4DC3_A_ADNA401_2","ADENOSINE KINASE","5k22","PROTEIN TYROSINE PHOSPHATASE TYPE IVA 2","Homo sapiens",4,"LEU A 105;ILE A 130;GLY A 106;PHE A 138","None","1.03A","4dc3A-5k22A:undetectable","4dc3A-5k22A:22.97"],["4EJG_C_NCTC501_1","CYTOCHROME P450 2A13","5k22","PROTEIN TYROSINE PHOSPHATASE TYPE IVA 2","Homo sapiens",4,"PHE A  16;ALA A 119;LEU A  82;LEU A  85","None","0.93A","4ejgC-5k22A:undetectable","4ejgC-5k22A:16.42"]]