SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5k2m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD6_0
(GRAMICIDIN A)		 5k2m RIMK-RELATED LYSINE
BIOSYNTHESIS PROTEIN
(Thermococcus
kodakarensis) 		4 / 4 VAL A 182
TRP A 218
ALA A 225
VAL A 176
 None
 1.25A 1gmkC-5k2mA:
undetectable
1gmkD-5k2mA:
undetectable		 1gmkC-5k2mA:
6.29
1gmkD-5k2mA:
6.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 5k2m RIMK-RELATED LYSINE
BIOSYNTHESIS PROTEIN
(Thermococcus
kodakarensis) 		5 / 11 LEU A 155
LEU A  57
GLU A  79
SER A  52
VAL A 124
 None
 1.09A 1ictA-5k2mA:
undetectable
1ictC-5k2mA:
undetectable		 1ictA-5k2mA:
20.79
1ictC-5k2mA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VRT_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 5k2m RIMK-RELATED LYSINE
BIOSYNTHESIS PROTEIN
(Thermococcus
kodakarensis) 		5 / 9 LEU A  35
VAL A  46
VAL A  28
TYR A   7
GLY A   4
 None
 1.49A 1vrtA-5k2mA:
undetectable		 1vrtA-5k2mA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 5k2m RIMK-RELATED LYSINE
BIOSYNTHESIS PROTEIN
(Thermococcus
kodakarensis) 		3 / 3 ARG A 253
GLU A  13
TYR A 175
 None
 0.89A 3k37B-5k2mA:
undetectable		 3k37B-5k2mA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5k2m PROBABLE LYSINE
BIOSYNTHESIS PROTEIN
RIMK-RELATED LYSINE
BIOSYNTHESIS PROTEIN
(Thermococcus
kodakarensis) 		4 / 5 GLU E  49
PHE A  54
TYR A 156
HIS A 159
 None
 1.29A 4a97J-5k2mE:
undetectable		 4a97J-5k2mE:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5k2m RIMK-RELATED LYSINE
BIOSYNTHESIS PROTEIN
(Thermococcus
kodakarensis) 		5 / 11 ILE A  17
ALA A 260
GLY A 261
GLU A 265
GLY A 183
 None
 1.17A 4e47A-5k2mA:
undetectable		 4e47A-5k2mA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5k2m RIMK-RELATED LYSINE
BIOSYNTHESIS PROTEIN
(Thermococcus
kodakarensis) 		5 / 11 ILE A  17
ALA A 260
GLY A 261
GLU A 265
GLY A 183
 None
 1.19A 4e47B-5k2mA:
undetectable		 4e47B-5k2mA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5k2m RIMK-RELATED LYSINE
BIOSYNTHESIS PROTEIN
(Thermococcus
kodakarensis) 		5 / 11 ILE A  17
ALA A 260
GLY A 261
GLU A 265
GLY A 183
 None
 1.14A 4e47C-5k2mA:
undetectable		 4e47C-5k2mA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5k2m RIMK-RELATED LYSINE
BIOSYNTHESIS PROTEIN
(Thermococcus
kodakarensis) 		5 / 11 ILE A  17
ALA A 260
GLY A 261
GLU A 265
GLY A 183
 None
 1.19A 4jdsA-5k2mA:
undetectable		 4jdsA-5k2mA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5k2m RIMK-RELATED LYSINE
BIOSYNTHESIS PROTEIN
(Thermococcus
kodakarensis) 		5 / 11 ILE A  17
ALA A 260
GLY A 261
GLU A 265
GLY A 183
 None
 1.17A 4jdsB-5k2mA:
undetectable		 4jdsB-5k2mA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5k2m RIMK-RELATED LYSINE
BIOSYNTHESIS PROTEIN
(Thermococcus
kodakarensis) 		5 / 11 ILE A  17
ALA A 260
GLY A 261
GLU A 265
GLY A 183
 None
 1.14A 4jdsC-5k2mA:
undetectable		 4jdsC-5k2mA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5k2m RIMK-RELATED LYSINE
BIOSYNTHESIS PROTEIN
(Thermococcus
kodakarensis) 		5 / 12 ILE A  17
ALA A 260
GLY A 261
GLU A 265
GLY A 183
 None
 1.11A 4jlgA-5k2mA:
undetectable		 4jlgA-5k2mA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 5k2m RIMK-RELATED LYSINE
BIOSYNTHESIS PROTEIN
(Thermococcus
kodakarensis) 		3 / 3 MET A  15
MET A 246
TYR A   7
 None
 1.27A 4p6xI-5k2mA:
undetectable		 4p6xI-5k2mA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5k2m RIMK-RELATED LYSINE
BIOSYNTHESIS PROTEIN
(Thermococcus
kodakarensis) 		5 / 11 ILE A  17
ALA A 260
GLY A 261
GLU A 265
GLY A 183
 None
 1.16A 5ayfA-5k2mA:
undetectable		 5ayfA-5k2mA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 5k2m PROBABLE LYSINE
BIOSYNTHESIS PROTEIN
(Thermococcus
kodakarensis) 		4 / 6 VAL E   2
LEU E  39
CYH E   4
LEU E  31
 None
None
ZN  E 102 (-2.5A)
None
 0.90A 5hrqB-5k2mE:
undetectable
5hrqI-5k2mE:
undetectable
5hrqJ-5k2mE:
undetectable		 5hrqB-5k2mE:
30.00
5hrqI-5k2mE:
20.00
5hrqJ-5k2mE:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 5k2m RIMK-RELATED LYSINE
BIOSYNTHESIS PROTEIN
(Thermococcus
kodakarensis) 		3 / 3 GLU A  66
LEU A  62
ARG A  61
 None
 0.82A 6d8fA-5k2mA:
undetectable		 6d8fA-5k2mA:
17.39