SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5k2y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 5k2y PROBABLE PERIPLASMIC
SUGAR-BINDING
LIPOPROTEIN USPC
(Mycobacterium
tuberculosis) 		4 / 8 MET A 345
PHE A  58
THR A  72
LEU A  45
 None
 1.24A 1ea1A-5k2yA:
undetectable		 1ea1A-5k2yA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 5k2y PROBABLE PERIPLASMIC
SUGAR-BINDING
LIPOPROTEIN USPC
(Mycobacterium
tuberculosis) 		5 / 12 ASP A 216
PHE A 287
ASN A 212
PHE A 385
VAL A 307
 None
 1.38A 2fqyA-5k2yA:
undetectable		 2fqyA-5k2yA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_A_DAHA2_1
(RANASMURFIN)		 5k2y PROBABLE PERIPLASMIC
SUGAR-BINDING
LIPOPROTEIN USPC
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 359
ALA A 295
SER A 293
PHE A 151
GLY A 290
 None
 1.44A 2vh3A-5k2yA:
undetectable		 2vh3A-5k2yA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1303_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5k2y PROBABLE PERIPLASMIC
SUGAR-BINDING
LIPOPROTEIN USPC
(Mycobacterium
tuberculosis) 		4 / 7 PRO A 141
ILE A 116
GLY A 346
TRP A 123
 None
 0.90A 2y7kA-5k2yA:
6.0		 2y7kA-5k2yA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 5k2y PROBABLE PERIPLASMIC
SUGAR-BINDING
LIPOPROTEIN USPC
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 320
ILE A 394
PHE A 249
PHE A 417
LEU A 252
 None
 1.30A 3apwB-5k2yA:
undetectable		 3apwB-5k2yA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 5k2y PROBABLE PERIPLASMIC
SUGAR-BINDING
LIPOPROTEIN USPC
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 286
GLN A 166
LEU A 170
TYR A 211
LEU A 187
 None
 1.42A 3fsuA-5k2yA:
undetectable		 3fsuA-5k2yA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_E_C2FE995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 5k2y PROBABLE PERIPLASMIC
SUGAR-BINDING
LIPOPROTEIN USPC
(Mycobacterium
tuberculosis) 		5 / 11 ASP A 178
GLN A 166
LEU A 170
TYR A 211
LEU A 187
 None
 1.42A 3fsuE-5k2yA:
undetectable		 3fsuE-5k2yA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 5k2y PROBABLE PERIPLASMIC
SUGAR-BINDING
LIPOPROTEIN USPC
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 409
GLY A 405
PHE A 238
PHE A 232
 None
 1.16A 3smtA-5k2yA:
undetectable		 3smtA-5k2yA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5k2y PROBABLE PERIPLASMIC
SUGAR-BINDING
LIPOPROTEIN USPC
(Mycobacterium
tuberculosis) 		4 / 8 TRP A  98
TYR A  77
ARG A  44
LEU A  74
 None
 1.15A 3wipG-5k2yA:
undetectable
3wipH-5k2yA:
undetectable		 3wipG-5k2yA:
17.39
3wipH-5k2yA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5k2y PROBABLE PERIPLASMIC
SUGAR-BINDING
LIPOPROTEIN USPC
(Mycobacterium
tuberculosis) 		4 / 8 ARG A  44
LEU A  74
TRP A  98
TYR A  77
 None
 1.19A 3wipF-5k2yA:
undetectable
3wipJ-5k2yA:
undetectable		 3wipF-5k2yA:
17.39
3wipJ-5k2yA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5k2y PROBABLE PERIPLASMIC
SUGAR-BINDING
LIPOPROTEIN USPC
(Mycobacterium
tuberculosis) 		3 / 3 GLY A 226
SER A 227
TRP A 172
 None
 0.90A 4e7cD-5k2yA:
undetectable		 4e7cD-5k2yA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 5k2y PROBABLE PERIPLASMIC
SUGAR-BINDING
LIPOPROTEIN USPC
(Mycobacterium
tuberculosis) 		4 / 6 ALA A 213
LEU A 252
VAL A 253
ASP A 259
 None
 1.05A 4g24A-5k2yA:
undetectable		 4g24A-5k2yA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 5k2y PROBABLE PERIPLASMIC
SUGAR-BINDING
LIPOPROTEIN USPC
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 364
SER A 347
TRP A 123
 None
 0.95A 5jwaA-5k2yA:
undetectable		 5jwaA-5k2yA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 5k2y PROBABLE PERIPLASMIC
SUGAR-BINDING
LIPOPROTEIN USPC
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 430
PHE A 232
PHE A 240
GLN A 218
LEU A 222
 None
 1.17A 5tudD-5k2yA:
undetectable		 5tudD-5k2yA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 5k2y PROBABLE PERIPLASMIC
SUGAR-BINDING
LIPOPROTEIN USPC
(Mycobacterium
tuberculosis) 		3 / 3 GLY A 230
ASN A 242
ARG A 234
 None
 0.61A 5w7bD-5k2yA:
undetectable		 5w7bD-5k2yA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5k2y PROBABLE PERIPLASMIC
SUGAR-BINDING
LIPOPROTEIN USPC
(Mycobacterium
tuberculosis) 		4 / 6 GLY A 272
ASN A 271
SER A 275
ARG A 276
 None
 1.04A 6dwdA-5k2yA:
undetectable
6dwdC-5k2yA:
undetectable		 6dwdA-5k2yA:
21.13
6dwdC-5k2yA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_A_H98A501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 5k2y PROBABLE PERIPLASMIC
SUGAR-BINDING
LIPOPROTEIN USPC
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 382
VAL A 380
ASP A 145
TRP A 305
PHE A 151
 None
 1.32A 6iblA-5k2yA:
undetectable		 6iblA-5k2yA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_B_H98B501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 5k2y PROBABLE PERIPLASMIC
SUGAR-BINDING
LIPOPROTEIN USPC
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 382
VAL A 380
ASP A 145
TRP A 305
PHE A 151
 None
 1.30A 6iblB-5k2yA:
undetectable		 6iblB-5k2yA:
24.26