SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5k2z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5k2z PYRIDOXAL
5'-PHOSPHATE
SYNTHASE SUBUNIT
PDX1.3
(Arabidopsis
thaliana) 		4 / 5 GLY A 149
PRO A 222
VAL A 223
ILE A 162
 None
None
EDO  A 406 (-4.6A)
None
 0.90A 2aoiA-5k2zA:
undetectable		 2aoiA-5k2zA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 5k2z PYRIDOXAL
5'-PHOSPHATE
SYNTHASE SUBUNIT
PDX1.3
(Arabidopsis
thaliana) 		3 / 3 LEU A 221
PRO A 222
ARG A 154
 None
None
SO4  A 402 (-3.1A)
 0.63A 2qd4B-5k2zA:
undetectable		 2qd4B-5k2zA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA702_0
(FERROCHELATASE)		 5k2z PYRIDOXAL
5'-PHOSPHATE
SYNTHASE SUBUNIT
PDX1.3
(Arabidopsis
thaliana) 		3 / 3 LEU A 221
PRO A 222
ARG A 154
 None
None
SO4  A 402 (-3.1A)
 0.62A 2qd5A-5k2zA:
undetectable		 2qd5A-5k2zA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 5k2z PYRIDOXAL
5'-PHOSPHATE
SYNTHASE SUBUNIT
PDX1.3
(Arabidopsis
thaliana) 		5 / 11 HIS A 179
ALA A 228
CYH A 145
GLY A 144
ILE A 162
 None
6R3  A 404 ( 4.3A)
None
EDO  A 405 (-4.1A)
None
 1.16A 2uxpB-5k2zA:
undetectable		 2uxpB-5k2zA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 5k2z PYRIDOXAL
5'-PHOSPHATE
SYNTHASE SUBUNIT
PDX1.3
(Arabidopsis
thaliana) 		5 / 12 GLY A 171
GLY A 293
LEU A 296
VAL A 231
VAL A 250
 None
None
None
None
SO4  A 403 ( 4.8A)
 1.11A 2zulA-5k2zA:
undetectable		 2zulA-5k2zA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 5k2z PYRIDOXAL
5'-PHOSPHATE
SYNTHASE SUBUNIT
PDX1.3
(Arabidopsis
thaliana) 		5 / 12 ALA A 227
ILE A 173
THR A 233
LEU A 280
PRO A 277
 None
 1.28A 3cl9A-5k2zA:
undetectable		 3cl9A-5k2zA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 5k2z PYRIDOXAL
5'-PHOSPHATE
SYNTHASE SUBUNIT
PDX1.3
(Arabidopsis
thaliana) 		5 / 12 THR A 272
ALA A 266
ASP A 259
LEU A 287
LEU A 280
 None
 1.38A 3lcvB-5k2zA:
undetectable		 3lcvB-5k2zA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 5k2z PYRIDOXAL
5'-PHOSPHATE
SYNTHASE SUBUNIT
PDX1.3
(Arabidopsis
thaliana) 		4 / 6 SER A 120
ARG A 163
GLY A 230
GLY A 169
 6R3  A 404 (-3.1A)
6R3  A 404 (-3.8A)
SO4  A 403 (-3.4A)
SO4  A 403 (-3.6A)
 0.85A 4koeA-5k2zA:
undetectable
4koeB-5k2zA:
undetectable
4koeC-5k2zA:
undetectable		 4koeA-5k2zA:
22.07
4koeB-5k2zA:
22.07
4koeC-5k2zA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 5k2z PYRIDOXAL
5'-PHOSPHATE
SYNTHASE SUBUNIT
PDX1.3
(Arabidopsis
thaliana) 		4 / 7 ARG A 163
SER A 120
GLY A 230
GLY A 169
 6R3  A 404 (-3.8A)
6R3  A 404 (-3.1A)
SO4  A 403 (-3.4A)
SO4  A 403 (-3.6A)
 0.84A 4koeA-5k2zA:
undetectable
4koeB-5k2zA:
undetectable
4koeD-5k2zA:
undetectable		 4koeA-5k2zA:
22.07
4koeB-5k2zA:
22.07
4koeD-5k2zA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 5k2z PYRIDOXAL
5'-PHOSPHATE
SYNTHASE SUBUNIT
PDX1.3
(Arabidopsis
thaliana) 		4 / 6 GLY A 230
GLY A 169
SER A 120
ARG A 163
 SO4  A 403 (-3.4A)
SO4  A 403 (-3.6A)
6R3  A 404 (-3.1A)
6R3  A 404 (-3.8A)
 0.83A 4z53A-5k2zA:
undetectable
4z53B-5k2zA:
undetectable		 4z53A-5k2zA:
19.65
4z53B-5k2zA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 5k2z PYRIDOXAL
5'-PHOSPHATE
SYNTHASE SUBUNIT
PDX1.3
(Arabidopsis
thaliana) 		4 / 7 ARG A 163
GLY A 230
GLY A 169
SER A 120
 6R3  A 404 (-3.8A)
SO4  A 403 (-3.4A)
SO4  A 403 (-3.6A)
6R3  A 404 (-3.1A)
 0.79A 4z53A-5k2zA:
undetectable
4z53B-5k2zA:
undetectable		 4z53A-5k2zA:
19.65
4z53B-5k2zA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5k2z PYRIDOXAL
5'-PHOSPHATE
SYNTHASE SUBUNIT
PDX1.3
(Arabidopsis
thaliana) 		5 / 12 ALA A 232
GLY A 169
GLY A 171
GLY A 293
GLU A 121
 None
SO4  A 403 (-3.6A)
None
None
EDO  A 405 ( 3.8A)
 0.93A 5c0oH-5k2zA:
undetectable		 5c0oH-5k2zA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 5k2z PYRIDOXAL
5'-PHOSPHATE
SYNTHASE SUBUNIT
PDX1.3
(Arabidopsis
thaliana) 		4 / 7 GLN A 242
LEU A 239
ASP A 236
LEU A 287
 None
 0.96A 5nwvA-5k2zA:
undetectable		 5nwvA-5k2zA:
7.77