SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5k34'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 5k34 ANKYRIN-REPEAT
PROTEIN B
(Legionella
pneumophila) 		3 / 3 LEU A  99
LEU A 113
MET A 159
 None
 0.62A 1ya3B-5k34A:
undetectable		 1ya3B-5k34A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 5k34 ANKYRIN-REPEAT
PROTEIN B
(Legionella
pneumophila) 		4 / 7 GLY A 104
GLN A 138
PHE A 144
ILE A 152
 None
 1.00A 2qmzA-5k34A:
undetectable
2qmzB-5k34A:
undetectable		 2qmzA-5k34A:
19.05
2qmzB-5k34A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 5k34 ANKYRIN-REPEAT
PROTEIN B
(Legionella
pneumophila) 		4 / 6 ILE A 102
ILE A  78
TRP A  60
MET A  64
 None
 1.32A 3weoA-5k34A:
undetectable		 3weoA-5k34A:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNU_A_BEZA319_0
(SHKAI2IB)		 5k34 ANKYRIN-REPEAT
PROTEIN B
(Legionella
pneumophila) 		4 / 5 GLN A 138
ILE A 152
ILE A 156
TYR A 107
 None
 1.18A 5dnuA-5k34A:
undetectable		 5dnuA-5k34A:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)		 5k34 ANKYRIN-REPEAT
PROTEIN B
(Legionella
pneumophila) 		4 / 5 GLN A 138
ILE A 152
ILE A 156
TYR A 107
 None
 1.14A 5dnvA-5k34A:
undetectable		 5dnvA-5k34A:
16.00