SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5k39'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1U72_A_MTXA188_1 (DIHYDROFOLATE REDUCTASE)	5k39	CELLULOSOME ANCHORING PROTEIN COHESIN REGION (Ruminiclostridiu m thermocellum)	5 / 12	LEU A 64 PHE A 58 GLN A 48 PRO A 52 VAL A 129	None	1.24A	1u72A-5k39A: undetectable	1u72A-5k39A: 21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EEO_A_SAMA328_1 (MODIFICATION METHYLASE HHAI)	5k39	CELLULOSOME ANCHORING PROTEIN COHESIN REGION (Ruminiclostridiu m thermocellum)	3 / 3	GLU A 74 SER A 105 VAL A 107	None	0.79A	3eeoA-5k39A: undetectable	3eeoA-5k39A: 19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PSY_A_FOLA201_0 (DIHYDROFOLATE REDUCTASE)	5k39	CELLULOSOME ANCHORING PROTEIN COHESIN REGION (Ruminiclostridiu m thermocellum)	5 / 12	ILE A 36 LEU A 8 ALA A 7 LYS A 26 THR A 144	None	0.99A	4psyA-5k39A: undetectable	4psyA-5k39A: 21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5C8T_D_SAMD605_0 (GUANINE-N7 METHYLTRANSFERASE)	5k39	CELLULOSOME ANCHORING PROTEIN COHESIN REGION (Ruminiclostridiu m thermocellum)	5 / 10	GLY A 88 PRO A 44 ALA A 49 GLN A 48 PHE A 58	None	1.38A	5c8tD-5k39A: undetectable	5c8tD-5k39A: 15.37

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1U72_A_MTXA188_1","DIHYDROFOLATE REDUCTASE","5k39","CELLULOSOME ANCHORING PROTEIN COHESIN REGION","Ruminiclostridium thermocellum",5,"LEU A  64;PHE A  58;GLN A  48;PRO A  52;VAL A 129","None","1.24A","1u72A-5k39A:undetectable","1u72A-5k39A:21.72"],["3EEO_A_SAMA328_1","MODIFICATION METHYLASE HHAI","5k39","CELLULOSOME ANCHORING PROTEIN COHESIN REGION","Ruminiclostridium thermocellum",3,"GLU A  74;SER A 105;VAL A 107","None","0.79A","3eeoA-5k39A:undetectable","3eeoA-5k39A:19.76"],["4PSY_A_FOLA201_0","DIHYDROFOLATE REDUCTASE","5k39","CELLULOSOME ANCHORING PROTEIN COHESIN REGION","Ruminiclostridium thermocellum",5,"ILE A  36;LEU A   8;ALA A   7;LYS A  26;THR A 144","None","0.99A","4psyA-5k39A:undetectable","4psyA-5k39A:21.79"],["5C8T_D_SAMD605_0","GUANINE-N7 METHYLTRANSFERASE","5k39","CELLULOSOME ANCHORING PROTEIN COHESIN REGION","Ruminiclostridium thermocellum",5,"GLY A  88;PRO A  44;ALA A  49;GLN A  48;PHE A  58","None","1.38A","5c8tD-5k39A:undetectable","5c8tD-5k39A:15.37"]]