SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5k3h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 304
ALA A 351
LEU A 615
ILE A 312
LEU A 625
 None
 1.16A 1ddrB-5k3hA:
undetectable		 1ddrB-5k3hA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 304
ALA A 351
LEU A 615
ILE A 312
LEU A 625
 None
 1.14A 1ddsA-5k3hA:
undetectable		 1ddsA-5k3hA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 304
ALA A 351
LEU A 615
ILE A 312
LEU A 625
 None
 1.19A 1ddsB-5k3hA:
undetectable		 1ddsB-5k3hA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 108
ALA A 427
ILE A 312
ARG A 315
LEU A 625
 None
 1.15A 1dyiA-5k3hA:
undetectable		 1dyiA-5k3hA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 304
ALA A 351
LEU A 615
ILE A 312
LEU A 625
 None
 1.15A 1dyiA-5k3hA:
undetectable		 1dyiA-5k3hA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		4 / 6 LEU A 310
LEU A 625
LEU A 566
LEU A 569
 None
 0.93A 1errA-5k3hA:
2.1		 1errA-5k3hA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		3 / 3 GLN A 355
ILE A 488
HIS A 568
 None
 0.62A 1fm9A-5k3hA:
undetectable		 1fm9A-5k3hA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 108
ALA A 427
ILE A 312
ARG A 315
LEU A 625
 None
 1.18A 1jolA-5k3hA:
undetectable		 1jolA-5k3hA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		3 / 3 GLN A 355
ILE A 488
HIS A 568
 None
 0.65A 1k74A-5k3hA:
undetectable		 1k74A-5k3hA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		5 / 11 LEU A 299
TYR A 297
ILE A 543
LEU A 383
LEU A 386
 None
 1.34A 1mrqA-5k3hA:
undetectable		 1mrqA-5k3hA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		5 / 12 SER A 307
SER A 617
PHE A  25
LEU A 563
PHE A 356
 None
 1.29A 1q23B-5k3hA:
undetectable		 1q23B-5k3hA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		5 / 12 SER A 307
SER A 617
PHE A  25
LEU A 563
PHE A 356
 None
 1.34A 1q23C-5k3hA:
undetectable		 1q23C-5k3hA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		5 / 10 SER A 307
SER A 617
PHE A  25
LEU A 563
PHE A 356
 None
 1.25A 1q23E-5k3hA:
undetectable		 1q23E-5k3hA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		5 / 11 SER A 307
SER A 617
PHE A  25
LEU A 563
PHE A 356
 None
 1.28A 1q23G-5k3hA:
undetectable		 1q23G-5k3hA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		5 / 11 SER A 307
SER A 617
PHE A  25
LEU A 563
PHE A 356
 None
 1.28A 1q23J-5k3hA:
undetectable		 1q23J-5k3hA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		5 / 10 SER A 307
SER A 617
PHE A  25
LEU A 563
PHE A 356
 None
 1.32A 1q23K-5k3hA:
undetectable		 1q23K-5k3hA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		4 / 7 ARG A  68
ASN A 250
ASP A 238
GLY A 110
 None
 0.98A 2f6dA-5k3hA:
undetectable		 2f6dA-5k3hA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		4 / 7 ALA A 353
ALA A 357
THR A 361
LEU A 386
 None
 0.74A 2wx2A-5k3hA:
undetectable		 2wx2A-5k3hA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		4 / 8 ALA A 353
ALA A 357
THR A 361
LEU A 386
 None
 0.78A 2wx2B-5k3hA:
undetectable		 2wx2B-5k3hA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 304
ALA A 351
LEU A 615
ILE A 312
LEU A 625
 None
 1.04A 2zzaA-5k3hA:
undetectable		 2zzaA-5k3hA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		5 / 11 ILE A 304
ALA A 351
LEU A 615
ILE A 312
LEU A 625
 None
 1.03A 2zzaB-5k3hA:
undetectable		 2zzaB-5k3hA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAU_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 304
ALA A 351
LEU A 615
ILE A 312
LEU A 625
 None
 1.03A 3dauA-5k3hA:
undetectable		 3dauA-5k3hA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		3 / 3 ASN A 639
ASP A  12
GLN A   9
 None
 0.72A 3eeyC-5k3hA:
undetectable		 3eeyC-5k3hA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		3 / 3 ASN A 639
ASP A  12
GLN A   9
 None
 0.72A 3eeyD-5k3hA:
undetectable		 3eeyD-5k3hA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		3 / 3 ASN A 639
ASP A  12
GLN A   9
 None
 0.72A 3eeyE-5k3hA:
undetectable		 3eeyE-5k3hA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		4 / 8 ALA A 353
ALA A 357
THR A 361
LEU A 386
 None
 0.70A 3khmA-5k3hA:
undetectable		 3khmA-5k3hA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		4 / 8 ALA A 353
ALA A 357
THR A 361
LEU A 386
 None
 0.66A 3l4dD-5k3hA:
2.5		 3l4dD-5k3hA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		3 / 3 ARG A  44
HIS A 100
TYR A  35
 None
 1.18A 4fu8A-5k3hA:
undetectable		 4fu8A-5k3hA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		3 / 3 ARG A  44
HIS A 100
TYR A  35
 None
 1.24A 4fu9A-5k3hA:
undetectable		 4fu9A-5k3hA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 304
ALA A 351
LEU A 615
ILE A 312
LEU A 625
 None
 1.11A 4gh8A-5k3hA:
undetectable		 4gh8A-5k3hA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		4 / 6 SER A  75
GLY A 194
ASP A 238
GLY A 191
 None
 0.84A 4koeA-5k3hA:
undetectable
4koeB-5k3hA:
undetectable
4koeC-5k3hA:
undetectable		 4koeA-5k3hA:
24.60
4koeB-5k3hA:
24.60
4koeC-5k3hA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		4 / 7 SER A  75
GLY A 194
ASP A 238
GLY A 191
 None
 0.83A 4koeA-5k3hA:
undetectable
4koeB-5k3hA:
undetectable
4koeD-5k3hA:
undetectable		 4koeA-5k3hA:
24.60
4koeB-5k3hA:
24.60
4koeD-5k3hA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		6 / 12 ALA A 427
GLY A 401
GLY A 399
LEU A 344
ILE A 348
LEU A 615
 None
 1.25A 4n49A-5k3hA:
undetectable		 4n49A-5k3hA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		5 / 12 ASP A 616
VAL A 612
ASN A 311
GLY A 630
ASP A 622
 None
 1.43A 4pevB-5k3hA:
undetectable		 4pevB-5k3hA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 108
ALA A 427
ILE A 312
ARG A 315
LEU A 625
 None
 1.12A 4qi9A-5k3hA:
undetectable		 4qi9A-5k3hA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 304
ALA A 351
LEU A 615
ILE A 312
LEU A 625
 None
 1.01A 4qi9A-5k3hA:
undetectable		 4qi9A-5k3hA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 108
ALA A 427
ILE A 312
ARG A 315
LEU A 625
 None
 1.09A 4qi9B-5k3hA:
undetectable		 4qi9B-5k3hA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 304
ALA A 351
LEU A 615
ILE A 312
LEU A 625
 None
 1.10A 4qi9B-5k3hA:
undetectable		 4qi9B-5k3hA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		5 / 11 ILE A 108
ALA A 427
ILE A 312
ARG A 315
LEU A 625
 None
 1.19A 4qi9C-5k3hA:
undetectable		 4qi9C-5k3hA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 108
ALA A 427
ILE A 312
ARG A 315
LEU A 625
 None
 1.13A 4qleA-5k3hA:
undetectable		 4qleA-5k3hA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 108
ALA A 427
ILE A 312
ARG A 315
LEU A 625
 None
 1.15A 4qlgA-5k3hA:
undetectable		 4qlgA-5k3hA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 304
ALA A 351
LEU A 615
ILE A 312
LEU A 625
 None
 1.09A 4qlgB-5k3hA:
undetectable		 4qlgB-5k3hA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 304
ALA A 351
LEU A 615
ILE A 312
LEU A 625
 None
 1.13A 4rgcA-5k3hA:
undetectable		 4rgcA-5k3hA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		3 / 3 GLU A 360
ILE A 492
ALA A 353
 None
 0.64A 4wnwB-5k3hA:
undetectable		 4wnwB-5k3hA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 108
ALA A 427
ILE A 312
ARG A 315
LEU A 625
 None
 1.14A 4x5fA-5k3hA:
undetectable		 4x5fA-5k3hA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 108
ALA A 427
ILE A 312
ARG A 315
LEU A 625
 None
 1.13A 4x5fB-5k3hA:
undetectable		 4x5fB-5k3hA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 108
ALA A 427
ILE A 312
ARG A 315
LEU A 625
 None
 1.14A 4x5gA-5k3hA:
undetectable		 4x5gA-5k3hA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 304
ALA A 351
LEU A 615
ILE A 312
LEU A 625
 None
 1.12A 4x5gA-5k3hA:
undetectable		 4x5gA-5k3hA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		4 / 6 GLY A 194
ASP A 238
GLY A 191
SER A  75
 None
 0.82A 4z53A-5k3hA:
undetectable
4z53B-5k3hA:
undetectable		 4z53A-5k3hA:
24.44
4z53B-5k3hA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		4 / 7 GLY A 194
ASP A 238
GLY A 191
SER A  75
 None
 0.81A 4z53A-5k3hA:
undetectable
4z53B-5k3hA:
undetectable		 4z53A-5k3hA:
24.44
4z53B-5k3hA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 108
ALA A 427
ILE A 312
ARG A 315
LEU A 625
 None
 1.09A 5hi6A-5k3hA:
undetectable		 5hi6A-5k3hA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 304
ALA A 351
LEU A 615
ILE A 312
LEU A 625
 None
 1.08A 5hi6A-5k3hA:
undetectable		 5hi6A-5k3hA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 108
ALA A 427
ILE A 312
ARG A 315
LEU A 625
 None
 1.16A 5hi6B-5k3hA:
undetectable		 5hi6B-5k3hA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		3 / 3 TYR A  99
TYR A 352
SER A 307
 None
 0.95A 5iktB-5k3hA:
undetectable		 5iktB-5k3hA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		3 / 3 ASP A 565
ASN A 572
GLN A 599
 None
 0.73A 5k7uA-5k3hA:
undetectable		 5k7uA-5k3hA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		4 / 4 GLN A  84
THR A  83
LEU A  51
LEU A  57
 None
 1.25A 5m5kB-5k3hA:
undetectable		 5m5kB-5k3hA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		5 / 10 ILE A 312
GLY A 630
GLY A 634
VAL A 612
LEU A 615
 None
 1.06A 5o96C-5k3hA:
undetectable
5o96D-5k3hA:
undetectable		 5o96C-5k3hA:
17.01
5o96D-5k3hA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		4 / 5 THR A 180
GLU A 153
THR A 152
LEU A 193
 None
 1.14A 5utuH-5k3hA:
undetectable		 5utuH-5k3hA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		5 / 12 ALA A 385
GLY A 389
ASP A 382
GLY A 464
LEU A 454
 None
 1.09A 5wwsA-5k3hA:
undetectable		 5wwsA-5k3hA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		3 / 3 GLN A 355
ILE A 488
HIS A 568
 None
 0.53A 5z12B-5k3hA:
undetectable		 5z12B-5k3hA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)		 5k3h ACYL-COENZYME A
OXIDASE
(Caenorhabditis
elegans) 		5 / 11 THR A  24
PHE A  25
SER A 617
THR A 314
ALA A 318
 None
 1.36A 6efnA-5k3hA:
undetectable		 6efnA-5k3hA:
20.86