SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5k3w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5k3w CPUTA1
(Curtobacterium
pusillum) 		4 / 7 ILE A 230
ALA A 205
ILE A 214
PRO A 224
 None
 0.91A 1oniB-5k3wA:
undetectable
1oniC-5k3wA:
undetectable		 1oniB-5k3wA:
19.00
1oniC-5k3wA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_2
(PROTEASE)		 5k3w CPUTA1
(Curtobacterium
pusillum) 		5 / 12 GLY A 192
ALA A 193
ASP A 194
ASP A 195
ILE A 278
 None
 0.91A 2q5kB-5k3wA:
undetectable		 2q5kB-5k3wA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 5k3w CPUTA1
(Curtobacterium
pusillum) 		5 / 12 TRP A 267
ALA A 275
LEU A 300
PHE A 242
VAL A 221
 None
 1.06A 2ve3A-5k3wA:
undetectable		 2ve3A-5k3wA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_3
(PHOSPHOLIPASE A2)		 5k3w CPUTA1
(Curtobacterium
pusillum) 		4 / 7 VAL A 199
ILE A 230
GLN A 228
LEU A  82
 None
 0.93A 3bjwF-5k3wA:
undetectable		 3bjwF-5k3wA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 5k3w CPUTA1
(Curtobacterium
pusillum) 		4 / 7 VAL A 199
ILE A 230
GLN A 228
LEU A  82
 None
 0.90A 3bjwH-5k3wA:
undetectable		 3bjwH-5k3wA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5k3w CPUTA1
(Curtobacterium
pusillum) 		6 / 11 GLY A 172
GLY A 229
ALA A 232
THR A 226
ARG A  75
GLU A  57
 None
None
None
None
PLP  A 401 (-2.6A)
None
 1.43A 3g89B-5k3wA:
undetectable		 3g89B-5k3wA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5k3w CPUTA1
(Curtobacterium
pusillum) 		6 / 12 GLY A 172
GLY A 229
ALA A 232
THR A 226
ARG A  75
GLU A  57
 None
None
None
None
PLP  A 401 (-2.6A)
None
 1.42A 3g8bA-5k3wA:
2.6		 3g8bA-5k3wA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5k3w CPUTA1
(Curtobacterium
pusillum) 		6 / 12 GLY A 172
GLY A 229
ALA A 232
THR A 226
ARG A  75
GLU A  57
 None
None
None
None
PLP  A 401 (-2.6A)
None
 1.39A 3g8bB-5k3wA:
undetectable		 3g8bB-5k3wA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_A_KANA2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5k3w CPUTA1
(Curtobacterium
pusillum) 		5 / 11 THR A   5
ALA A 102
SER A 106
ASN A 108
ARG A 107
 None
 1.47A 3kp5A-5k3wA:
undetectable		 3kp5A-5k3wA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5k3w CPUTA1
(Curtobacterium
pusillum) 		3 / 3 GLY A 123
SER A 131
TRP A 133
 None
 1.00A 4e7cD-5k3wA:
undetectable		 4e7cD-5k3wA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5k3w CPUTA1
(Curtobacterium
pusillum) 		4 / 6 ASP A 227
ASP A 202
ASP A 161
GLU A 164
 None
 1.27A 4gkhJ-5k3wA:
undetectable		 4gkhJ-5k3wA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5k3w CPUTA1
(Curtobacterium
pusillum) 		3 / 3 THR A 180
HIS A 160
LEU A 206
 None
 0.82A 5axdA-5k3wA:
undetectable		 5axdA-5k3wA:
22.35