SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5k47'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 5k47 POLYCYSTIN-2
(Homo
sapiens) 		4 / 5 ALA A 647
ILE A 649
ASN A 645
ILE A 644
 None
 1.05A 2h4jA-5k47A:
undetectable		 2h4jA-5k47A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 5k47 POLYCYSTIN-2
(Homo
sapiens) 		5 / 9 ILE A 321
PHE A 279
THR A 283
VAL A 406
LEU A 415
 None
 1.14A 2m9qA-5k47A:
undetectable		 2m9qA-5k47A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 5k47 POLYCYSTIN-2
(Homo
sapiens) 		4 / 8 SER A 530
ASN A 525
ILE A 526
TYR A 465
 None
 0.87A 2v57A-5k47A:
undetectable		 2v57A-5k47A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 5k47 POLYCYSTIN-2
(Homo
sapiens) 		4 / 8 SER A 530
ASN A 525
ILE A 526
TYR A 465
 None
 0.86A 2v57C-5k47A:
undetectable		 2v57C-5k47A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 5k47 POLYCYSTIN-2
(Homo
sapiens) 		5 / 10 VAL A 350
LEU A 374
LEU A 324
ARG A 322
GLY A 390
 None
NAG  A 803 (-4.8A)
None
None
None
 1.23A 2xf3A-5k47A:
undetectable		 2xf3A-5k47A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_D_DVAD8_0
(VAL-GRAMICIDIN A)		 5k47 POLYCYSTIN-2
(Homo
sapiens) 		3 / 3 TRP A 366
VAL A 406
TRP A 414
 None
 1.15A 3zq8C-5k47A:
undetectable
3zq8D-5k47A:
undetectable		 3zq8C-5k47A:
4.04
3zq8D-5k47A:
4.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 5k47 POLYCYSTIN-2
(Homo
sapiens) 		4 / 8 ASN A 525
ALA A 521
LEU A 234
LEU A 237
 None
 0.90A 4ejgB-5k47A:
undetectable		 4ejgB-5k47A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)		 5k47 POLYCYSTIN-2
(Homo
sapiens) 		4 / 7 ASN A 525
ALA A 521
LEU A 234
LEU A 237
 None
 0.92A 4ejgC-5k47A:
undetectable		 4ejgC-5k47A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1008_1
(SERUM ALBUMIN)		 5k47 POLYCYSTIN-2
(Homo
sapiens) 		5 / 9 PHE A 480
PHE A 482
VAL A 488
SER A 518
VAL A 515
 None
 1.43A 4z69A-5k47A:
4.2		 4z69A-5k47A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5k47 POLYCYSTIN-2
(Homo
sapiens) 		4 / 7 GLY A 376
PHE A 436
ASP A 425
PHE A 426
 None
 1.12A 5hieA-5k47A:
undetectable		 5hieA-5k47A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HSW_A_ACTA501_0
(ORF 37)		 5k47 POLYCYSTIN-2
(Homo
sapiens) 		4 / 5 SER A 351
SER A 352
SER A 349
SER A 330
 None
 1.46A 5hswA-5k47A:
undetectable		 5hswA-5k47A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_B_DZPB502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		 5k47 POLYCYSTIN-2
(Homo
sapiens) 		5 / 11 ILE A 236
LEU A 237
THR A 565
LEU A 229
PHE A 230
 None
 1.43A 6hupA-5k47A:
4.4
6hupB-5k47A:
undetectable		 6hupA-5k47A:
10.29
6hupB-5k47A:
8.36