SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5k4g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)		 5k4g L-ASPARAGINASE
(Wolinella
succinogenes) 		3 / 3 ALA A  72
VAL A  67
TRP A  68
 None
 0.91A 1bdwA-5k4gA:
undetectable
1bdwB-5k4gA:
undetectable		 1bdwA-5k4gA:
5.12
1bdwB-5k4gA:
5.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 5k4g L-ASPARAGINASE
(Wolinella
succinogenes) 		4 / 6 ASN A 147
ILE A 183
ASN A 104
THR A 202
 None
 1.18A 1h7xB-5k4gA:
3.0		 1h7xB-5k4gA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 5k4g L-ASPARAGINASE
(Wolinella
succinogenes) 		3 / 3 LYS A 291
SER A 328
GLN A 324
 None
 1.30A 3si7A-5k4gA:
undetectable		 3si7A-5k4gA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_A_ACTA1002_0
(ACTIN, ALPHA
SKELETAL MUSCLE
FORMIN-LIKE PROTEIN
3)		 5k4g L-ASPARAGINASE
(Wolinella
succinogenes) 		4 / 5 ARG A 273
GLN A 284
GLU A 299
THR A 282
 None
 1.47A 4eahA-5k4gA:
undetectable
4eahE-5k4gA:
undetectable
4eahG-5k4gA:
2.3		 4eahA-5k4gA:
22.74
4eahE-5k4gA:
22.74
4eahG-5k4gA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_ACTA202_0
(RETINOL-BINDING
PROTEIN 2)		 5k4g L-ASPARAGINASE
(Wolinella
succinogenes) 		4 / 6 GLU A  97
THR A 165
LEU A 167
GLN A 304
 None
 1.46A 4qztA-5k4gA:
undetectable		 4qztA-5k4gA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA502_1
(CYTOCHROME P450 2C9)		 5k4g L-ASPARAGINASE
(Wolinella
succinogenes) 		4 / 6 PRO A 255
THR A 257
ASN A 259
LYS A 263
 None
 1.14A 5xxiA-5k4gA:
undetectable		 5xxiA-5k4gA:
22.17