SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5k4p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5k4p PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1
(Escherichia
coli) 		4 / 4 SER A 464
ASP A 366
ARG A 365
ASP A 404
 None
 1.46A 2bm9C-5k4pA:
undetectable		 2bm9C-5k4pA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 5k4p PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1
(Escherichia
coli) 		5 / 11 GLY A 467
SER A 469
THR A 283
GLY A 479
PHE A 484
 None
None
SOR  A 611 (-3.5A)
SOR  A 611 (-3.8A)
None
 1.18A 2hmaA-5k4pA:
undetectable		 2hmaA-5k4pA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 5k4p PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1
(Escherichia
coli) 		3 / 3 ASP A 384
ASP A 457
ASP A 233
 None
 0.67A 2igtA-5k4pA:
undetectable		 2igtA-5k4pA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)		 5k4p PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1
(Escherichia
coli) 		3 / 3 TYR A 431
ASP A 251
HIS A 466
 None
None
ZN  A 601 (-3.1A)
 0.92A 3e23A-5k4pA:
undetectable		 3e23A-5k4pA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)		 5k4p PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1
(Escherichia
coli) 		5 / 12 LEU A 316
GLY A 320
ARG A 235
PHE A 526
MET A 388
 None
ZN  A 608 ( 4.6A)
None
None
None
 1.19A 3h52C-5k4pA:
undetectable		 3h52C-5k4pA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 5k4p PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1
(Escherichia
coli) 		4 / 5 GLY A 372
THR A 451
VAL A 377
ASP A 375
 None
 1.03A 4eohA-5k4pA:
undetectable		 4eohA-5k4pA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 5k4p PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1
(Escherichia
coli) 		5 / 12 SER A 453
ILE A 446
ASP A 440
GLN A 265
ILE A 269
 None
 1.37A 4uroB-5k4pA:
undetectable		 4uroB-5k4pA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 5k4p PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1
(Escherichia
coli) 		5 / 12 LEU A 513
LEU A 522
VAL A 312
VAL A 463
PHE A 242
 None
 1.17A 4wnwA-5k4pA:
undetectable		 4wnwA-5k4pA:
20.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 5k4p PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1
(Escherichia
coli) 		6 / 6 GLY A 282
THR A 283
SER A 284
TYR A 287
GLY A 479
ASN A 482
 SOR  A 611 (-3.1A)
SOR  A 611 (-3.5A)
SOR  A 611 (-2.8A)
SOR  A 611 ( 4.0A)
SOR  A 611 (-3.8A)
SOR  A 611 (-3.1A)
 0.00A 5k4pA-5k4pA:
61.1		 5k4pA-5k4pA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 5k4p PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1
(Escherichia
coli) 		5 / 12 VAL A 289
HIS A 390
THR A 438
ARG A 402
GLY A 467
 TPO  A 285 ( 3.6A)
None
None
None
None
 1.29A 5ogcB-5k4pA:
undetectable		 5ogcB-5k4pA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5k4p PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1
(Escherichia
coli) 		5 / 10 TYR A 403
ILE A 442
ILE A 446
LEU A 449
ASN A 328
 None
 1.43A 5vkqA-5k4pA:
undetectable
5vkqD-5k4pA:
undetectable		 5vkqA-5k4pA:
11.69
5vkqD-5k4pA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5k4p PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1
(Escherichia
coli) 		5 / 10 ASN A 328
TYR A 403
ILE A 442
ILE A 446
LEU A 449
 None
 1.39A 5vkqA-5k4pA:
undetectable
5vkqB-5k4pA:
undetectable		 5vkqA-5k4pA:
11.69
5vkqB-5k4pA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5k4p PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1
(Escherichia
coli) 		5 / 10 ASN A 328
TYR A 403
ILE A 442
ILE A 446
LEU A 449
 None
 1.42A 5vkqC-5k4pA:
undetectable
5vkqD-5k4pA:
undetectable		 5vkqC-5k4pA:
11.69
5vkqD-5k4pA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5k4p PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1
(Escherichia
coli) 		4 / 8 ILE A 220
THR A 219
THR A 315
ARG A 318
 None
 1.14A 6c06C-5k4pA:
undetectable		 6c06C-5k4pA:
undetectable