SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5k50'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 5k50 L-THREONINE
3-DEHYDROGENASE
(Trypanosoma
brucei) 		5 / 12 MET A1217
ALA A1021
THR A1179
LEU A1045
LEU A1077
 None
None
None
None
NAD  A1401 (-4.3A)
 1.35A 1eiiA-5k50A:
undetectable		 1eiiA-5k50A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB8_0
(GRAMICIDIN A)		 5k50 L-THREONINE
3-DEHYDROGENASE
(Trypanosoma
brucei) 		4 / 5 VAL A1146
GLY A1145
VAL A1143
TRP A1280
 None
 1.30A 1tkqB-5k50A:
undetectable		 1tkqB-5k50A:
3.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 5k50 L-THREONINE
3-DEHYDROGENASE
(Trypanosoma
brucei) 		3 / 3 ASP A1058
GLU A1068
TYR A1110
 None
 0.84A 1wsvA-5k50A:
undetectable		 1wsvA-5k50A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5k50 L-THREONINE
3-DEHYDROGENASE
(Trypanosoma
brucei) 		3 / 3 SER A1019
ASP A1035
CYH A1056
 None
NAD  A1401 (-2.8A)
NAD  A1401 (-3.7A)
 0.83A 2br4E-5k50A:
4.9		 2br4E-5k50A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5k50 L-THREONINE
3-DEHYDROGENASE
(Trypanosoma
brucei) 		4 / 5 PRO A1078
THR A1142
VAL A1143
GLY A1145
 NAD  A1401 (-4.3A)
None
None
None
 1.03A 3elzA-5k50A:
undetectable		 3elzA-5k50A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_A_DX2A271_1
(PTERIDINE REDUCTASE
1)		 5k50 L-THREONINE
3-DEHYDROGENASE
(Trypanosoma
brucei) 		5 / 10 ASP A1134
VAL A1169
LEU A1171
PRO A1172
MET A1215
 None
None
NAD  A1401 ( 4.0A)
None
None
 0.88A 3jq7A-5k50A:
16.7		 3jq7A-5k50A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 5k50 L-THREONINE
3-DEHYDROGENASE
(Trypanosoma
brucei) 		4 / 6 GLY A1012
GLY A1015
LEU A1020
HIS A1043
 NAD  A1401 (-3.4A)
None
None
None
 0.83A 3o9mB-5k50A:
4.0		 3o9mB-5k50A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 5k50 L-THREONINE
3-DEHYDROGENASE
(Trypanosoma
brucei) 		3 / 3 ARG A1167
THR A1072
TRP A1073
 None
 0.93A 4d7hA-5k50A:
undetectable		 4d7hA-5k50A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)		 5k50 L-THREONINE
3-DEHYDROGENASE
(Trypanosoma
brucei) 		4 / 6 LEU A1057
ASN A1098
LEU A1091
VAL A1143
 NAD  A1401 ( 4.9A)
None
None
None
 1.08A 4okbA-5k50A:
undetectable		 4okbA-5k50A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 5k50 L-THREONINE
3-DEHYDROGENASE
(Trypanosoma
brucei) 		3 / 3 ARG A1167
THR A1072
TRP A1073
 None
 0.91A 4uglA-5k50A:
undetectable		 4uglA-5k50A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_A_EF2A151_1
(CEREBLON ISOFORM 4)		 5k50 L-THREONINE
3-DEHYDROGENASE
(Trypanosoma
brucei) 		4 / 7 PRO A1281
PHE A1123
TRP A1280
TYR A1144
 None
None
None
GOL  A1402 ( 4.3A)
 1.41A 4v2yA-5k50A:
undetectable		 4v2yA-5k50A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_A_Y70A151_1
(CEREBLON ISOFORM 4)		 5k50 L-THREONINE
3-DEHYDROGENASE
(Trypanosoma
brucei) 		4 / 7 PRO A1281
PHE A1123
TRP A1280
TYR A1144
 None
None
None
GOL  A1402 ( 4.3A)
 1.35A 4v2zA-5k50A:
undetectable		 4v2zA-5k50A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMH_A_EF2A151_1
(CEREBLON ISOFORM 4)		 5k50 L-THREONINE
3-DEHYDROGENASE
(Trypanosoma
brucei) 		4 / 7 PRO A1281
PHE A1123
TRP A1280
TYR A1144
 None
None
None
GOL  A1402 ( 4.3A)
 1.41A 5amhA-5k50A:
undetectable		 5amhA-5k50A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_A_EF2A151_1
(CEREBLON ISOFORM 4)		 5k50 L-THREONINE
3-DEHYDROGENASE
(Trypanosoma
brucei) 		4 / 7 PRO A1281
PHE A1123
TRP A1280
TYR A1144
 None
None
None
GOL  A1402 ( 4.3A)
 1.39A 5amiA-5k50A:
undetectable		 5amiA-5k50A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		 5k50 L-THREONINE
3-DEHYDROGENASE
(Trypanosoma
brucei) 		4 / 8 PRO A1281
PHE A1123
TRP A1280
TYR A1144
 None
None
None
GOL  A1402 ( 4.3A)
 1.31A 5amiB-5k50A:
undetectable		 5amiB-5k50A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMJ_A_EF2A151_1
(CEREBLON ISOFORM 4)		 5k50 L-THREONINE
3-DEHYDROGENASE
(Trypanosoma
brucei) 		4 / 7 PRO A1281
PHE A1123
TRP A1280
TYR A1144
 None
None
None
GOL  A1402 ( 4.3A)
 1.37A 5amjA-5k50A:
undetectable		 5amjA-5k50A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		 5k50 L-THREONINE
3-DEHYDROGENASE
(Trypanosoma
brucei) 		4 / 8 PRO A1281
PHE A1123
TRP A1280
TYR A1144
 None
None
None
GOL  A1402 ( 4.3A)
 1.21A 5amkA-5k50A:
undetectable		 5amkA-5k50A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 5k50 L-THREONINE
3-DEHYDROGENASE
(Trypanosoma
brucei) 		3 / 3 ARG A1167
THR A1072
TRP A1073
 None
 0.92A 5g6cA-5k50A:
undetectable		 5g6cA-5k50A:
22.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 5k50 L-THREONINE
3-DEHYDROGENASE
(Trypanosoma
brucei) 		5 / 5 MET A1081
SER A1082
VAL A1083
GLY A1184
ALA A1185
 NAD  A1401 (-3.7A)
ACT  A1403 (-4.3A)
ACT  A1403 (-3.9A)
ACT  A1403 (-3.4A)
ACT  A1403 (-3.3A)
 0.02A 5k50A-5k50A:
58.0		 5k50A-5k50A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5K50_C_ACTC1403_0
(L-THREONINE
3-DEHYDROGENASE)		 5k50 L-THREONINE
3-DEHYDROGENASE
(Trypanosoma
brucei) 		4 / 4 MET A1081
SER A1082
VAL A1083
GLY A1184
 NAD  A1401 (-3.7A)
ACT  A1403 (-4.3A)
ACT  A1403 (-3.9A)
ACT  A1403 (-3.4A)
 0.66A 5k50C-5k50A:
54.2		 5k50C-5k50A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 5k50 L-THREONINE
3-DEHYDROGENASE
(Trypanosoma
brucei) 		5 / 12 SER A1176
GLY A1015
GLY A1012
VAL A1007
LEU A1018
 None
None
NAD  A1401 (-3.4A)
None
None
 1.19A 5kocB-5k50A:
4.5		 5kocB-5k50A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 5k50 L-THREONINE
3-DEHYDROGENASE
(Trypanosoma
brucei) 		4 / 5 GLU A1086
GLY A1145
SER A1141
GLY A1124
 None
 1.15A 5kprA-5k50A:
undetectable		 5kprA-5k50A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_A_EF2A202_0
(CEREBLON ISOFORM 4)		 5k50 L-THREONINE
3-DEHYDROGENASE
(Trypanosoma
brucei) 		4 / 7 PRO A1281
PHE A1123
TRP A1280
TYR A1144
 None
None
None
GOL  A1402 ( 4.3A)
 1.41A 5oh1A-5k50A:
undetectable		 5oh1A-5k50A:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_B_EF2B202_0
(CEREBLON ISOFORM 4)		 5k50 L-THREONINE
3-DEHYDROGENASE
(Trypanosoma
brucei) 		4 / 7 PRO A1281
PHE A1123
TRP A1280
TYR A1144
 None
None
None
GOL  A1402 ( 4.3A)
 1.34A 5oh1B-5k50A:
undetectable		 5oh1B-5k50A:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH3_A_9V2A202_0
(CEREBLON ISOFORM 4)		 5k50 L-THREONINE
3-DEHYDROGENASE
(Trypanosoma
brucei) 		4 / 7 PRO A1281
PHE A1123
TRP A1280
TYR A1144
 None
None
None
GOL  A1402 ( 4.3A)
 1.40A 5oh3A-5k50A:
undetectable		 5oh3A-5k50A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH3_B_9V2B202_0
(CEREBLON ISOFORM 4)		 5k50 L-THREONINE
3-DEHYDROGENASE
(Trypanosoma
brucei) 		4 / 7 PRO A1281
PHE A1123
TRP A1280
TYR A1144
 None
None
None
GOL  A1402 ( 4.3A)
 1.31A 5oh3B-5k50A:
undetectable		 5oh3B-5k50A:
17.73