SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5k51'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 5k51 HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Trypanosoma
brucei) 		5 / 11 SER A 136
HIS A 108
LEU A  67
CYH A  38
ILE A  31
 None
 1.40A 1ee2B-5k51A:
undetectable		 1ee2B-5k51A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 5k51 HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Trypanosoma
brucei) 		4 / 7 VAL A 181
TYR A 174
TYR A 178
GLY A 169
 None
 1.01A 1lweA-5k51A:
undetectable		 1lweA-5k51A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA601_1
(SERUM ALBUMIN)		 5k51 HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Trypanosoma
brucei) 		5 / 11 TYR A 157
VAL A  72
GLY A  68
THR A  74
LEU A  47
 None
 1.43A 4or0A-5k51A:
undetectable		 4or0A-5k51A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 5k51 HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Trypanosoma
brucei) 		4 / 6 LEU A  79
LEU A 112
VAL A 111
PHE A  78
 None
 1.23A 4uswA-5k51A:
undetectable		 4uswA-5k51A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 5k51 HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Trypanosoma
brucei) 		4 / 4 ASP A 173
GLY A  55
ASP A 114
ASP A 117
 None
None
None
6QD  A 301 (-4.3A)
 1.16A 5e72A-5k51A:
undetectable		 5e72A-5k51A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5k51 HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Trypanosoma
brucei) 		5 / 9 VAL A 191
GLY A 169
VAL A 185
ASP A 173
GLY A 171
 None
 1.40A 5zniA-5k51A:
undetectable		 5zniA-5k51A:
17.14