SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5k59'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 1
(Staphylococcus
aureus) 		3 / 3 VAL B  86
VAL B 170
TRP B 168
 None
 0.98A 1av2C-5k59B:
undetectable
1av2D-5k59B:
undetectable		 1av2C-5k59B:
8.59
1av2D-5k59B:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 2
(Staphylococcus
aureus) 		3 / 3 VAL D 113
VAL D 193
TRP D 191
 None
 0.72A 1av2C-5k59D:
undetectable
1av2D-5k59D:
undetectable		 1av2C-5k59D:
4.52
1av2D-5k59D:
4.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 1
(Staphylococcus
aureus) 		4 / 6 ASN B  75
ALA B 209
GLY B  72
TYR B  73
 None
 1.10A 1l7xB-5k59B:
undetectable		 1l7xB-5k59B:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 1
UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 2
(Staphylococcus
aureus;
Staphylococcus
aureus) 		3 / 3 ASP D 140
THR D 142
GLU B 139
 None
 0.84A 1pj7A-5k59D:
undetectable		 1pj7A-5k59D:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB8_0
(GRAMICIDIN D)		 5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 2
(Staphylococcus
aureus) 		3 / 3 VAL D 117
VAL D 189
TRP D 187
 None
 0.94A 1w5uA-5k59D:
undetectable
1w5uB-5k59D:
undetectable		 1w5uA-5k59D:
4.52
1w5uB-5k59D:
4.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD8_0
(GRAMICIDIN D)		 5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 2
(Staphylococcus
aureus) 		3 / 3 VAL D 113
VAL D 193
TRP D 191
 None
 0.79A 1w5uC-5k59D:
undetectable
1w5uD-5k59D:
undetectable		 1w5uC-5k59D:
4.52
1w5uD-5k59D:
4.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 1
(Staphylococcus
aureus) 		5 / 12 THR B 222
GLY B 226
GLY B  62
GLY B  64
GLN B 149
 None
 1.06A 1wg8A-5k59B:
undetectable		 1wg8A-5k59B:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 1
(Staphylococcus
aureus) 		5 / 12 THR B 222
GLY B 226
GLY B  62
GLY B  64
GLN B 149
 None
 1.10A 1wg8B-5k59B:
undetectable		 1wg8B-5k59B:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1434_1
(CHITINASE)		 5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 1
UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 2
(Staphylococcus
aureus) 		3 / 3 TRP B  80
THR B 183
TYR D 233
 None
 1.27A 2a3aA-5k59B:
undetectable		 2a3aA-5k59B:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1434_1
(CHITINASE)		 5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 1
UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 2
(Staphylococcus
aureus) 		3 / 3 TRP B  80
THR B 183
TYR D 233
 None
 1.26A 2a3bA-5k59B:
undetectable		 2a3bA-5k59B:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		 5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 2
(Staphylococcus
aureus) 		4 / 8 ASP D 152
SER D 144
SER D 164
ASN D 163
 None
 1.13A 2cmlB-5k59D:
undetectable		 2cmlB-5k59D:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)		 5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 2
(Staphylococcus
aureus) 		4 / 7 ASN D 175
ASP D 197
GLY D 201
TYR D 200
 None
None
CL  D 401 (-3.8A)
None
 1.03A 2f6dA-5k59D:
undetectable		 2f6dA-5k59D:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)		 5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 1
(Staphylococcus
aureus) 		3 / 3 VAL B 170
TRP B 168
VAL B  86
 None
 0.93A 2izqA-5k59B:
undetectable
2izqB-5k59B:
undetectable		 2izqA-5k59B:
8.59
2izqB-5k59B:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)		 5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 2
(Staphylococcus
aureus) 		3 / 3 VAL D 193
TRP D 191
VAL D 113
 None
 0.72A 2izqA-5k59D:
undetectable
2izqB-5k59D:
undetectable		 2izqA-5k59D:
4.52
2izqB-5k59D:
4.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC8_0
(GRAMICIDIN D)		 5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 2
(Staphylococcus
aureus) 		3 / 3 VAL D 189
TRP D 187
VAL D 117
 None
 0.91A 2izqC-5k59D:
undetectable
2izqD-5k59D:
undetectable		 2izqC-5k59D:
4.52
2izqD-5k59D:
4.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 2
(Staphylococcus
aureus) 		4 / 6 PRO D 245
HIS D 112
ASP D 114
TYR D 266
 None
 1.34A 2lh8A-5k59D:
undetectable		 2lh8A-5k59D:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)		 5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 2
(Staphylococcus
aureus) 		4 / 7 GLY D 149
GLY D 148
ASP D  75
LEU D 126
 None
 0.74A 2oa1B-5k59D:
undetectable		 2oa1B-5k59D:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 1
(Staphylococcus
aureus) 		4 / 7 ALA B 103
TYR B 115
TYR B 117
ASP B 101
 None
 1.40A 2pncA-5k59B:
undetectable		 2pncA-5k59B:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 1
(Staphylococcus
aureus) 		3 / 3 VAL B  86
VAL B 170
TRP B 168
 None
 0.77A 3l8lA-5k59B:
undetectable
3l8lB-5k59B:
undetectable		 3l8lA-5k59B:
8.59
3l8lB-5k59B:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 2
(Staphylococcus
aureus) 		3 / 3 VAL D 113
VAL D 193
TRP D 191
 None
 0.58A 3l8lA-5k59D:
undetectable
3l8lB-5k59D:
undetectable		 3l8lA-5k59D:
4.52
3l8lB-5k59D:
3.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)		 5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 2
(Staphylococcus
aureus) 		3 / 3 VAL D 113
VAL D 193
TRP D 191
 None
 0.85A 3l8lC-5k59D:
undetectable
3l8lD-5k59D:
undetectable		 3l8lC-5k59D:
4.52
3l8lD-5k59D:
3.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGA_A_ACTA1131_0
(LYSOZYME C)		 5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 2
(Staphylococcus
aureus) 		3 / 3 ASN D 196
ASP D 197
ASN D 206
 None
 0.80A 4agaA-5k59D:
undetectable		 4agaA-5k59D:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 1
(Staphylococcus
aureus) 		4 / 6 HIS B 276
GLU B 274
ASP B 261
SER B 272
 None
 1.06A 4apjA-5k59B:
undetectable
4apjP-5k59B:
undetectable		 4apjA-5k59B:
18.52
4apjP-5k59B:
3.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 2
(Staphylococcus
aureus) 		4 / 5 ILE D  60
ASN D 269
TYR D 111
ILE D  87
 None
 1.08A 4jtpA-5k59D:
undetectable		 4jtpA-5k59D:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 1
(Staphylococcus
aureus) 		3 / 4 SER B 196
GLY B  82
GLU B 282
 None
 0.42A 4juoA-5k59B:
undetectable
4juoC-5k59B:
undetectable		 4juoA-5k59B:
21.13
4juoC-5k59B:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 1
(Staphylococcus
aureus) 		4 / 6 ASP B 256
ASP B 278
SER B  85
ALA B 172
 None
 1.12A 4nedA-5k59B:
undetectable		 4nedA-5k59B:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 2
(Staphylococcus
aureus) 		3 / 3 GLU D 110
LYS D 288
ASN D 269
 None
 1.01A 4y1dA-5k59D:
undetectable
4y1dD-5k59D:
undetectable		 4y1dA-5k59D:
17.70
4y1dD-5k59D:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)		 5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 1
(Staphylococcus
aureus) 		3 / 3 TYR B  21
LYS B  19
LYS B  12
 None
 1.36A 5dbyA-5k59B:
undetectable		 5dbyA-5k59B:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 1
(Staphylococcus
aureus) 		5 / 10 VAL B 166
GLY B 167
ILE B 146
LEU B 232
ALA B 233
 None
 1.01A 5vm8B-5k59B:
undetectable		 5vm8B-5k59B:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 2
(Staphylococcus
aureus) 		3 / 3 SER D 181
HIS D 190
TYR D 321
 None
 0.95A 5y2tA-5k59D:
undetectable		 5y2tA-5k59D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 2
(Staphylococcus
aureus) 		3 / 3 LYS D 319
PRO D 320
LYS D 322
 None
 0.73A 5y9yA-5k59D:
undetectable		 5y9yA-5k59D:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 1
(Staphylococcus
aureus) 		4 / 5 ASP B 101
ILE B  88
ASN B 141
TYR B 117
 None
 1.17A 6a93B-5k59B:
undetectable		 6a93B-5k59B:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 1
UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 2
(Staphylococcus
aureus;
Staphylococcus
aureus) 		4 / 5 ASP D  67
ILE D 169
ASN B 135
TYR D 165
 None
 1.15A 6a93B-5k59D:
undetectable		 6a93B-5k59D:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_ACTA405_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 2
(Staphylococcus
aureus) 		4 / 6 THR D 217
ARG D 215
PRO D 277
ILE D 219
 None
 1.41A 6ef6A-5k59D:
0.8		 6ef6A-5k59D:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 1
(Staphylococcus
aureus) 		4 / 6 VAL B 277
ASN B 275
ASN B 188
ILE B 198
 None
 0.96A 6h7uA-5k59B:
undetectable		 6h7uA-5k59B:
20.16