SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5k5a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N6A_A_SAMA402_0
(SET
DOMAIN-CONTAINING
PROTEIN 7)		 5k5a PARB DOMAIN PROTEIN
NUCLEASE
(Sulfolobus
solfataricus) 		5 / 10 ILE B 201
ALA B 171
GLU B 158
ASN B 202
TYR B 226
 None
 1.09A 1n6aA-5k5aB:
0.0		 1n6aA-5k5aB:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N6C_A_SAMA402_0
(SET
DOMAIN-CONTAINING
PROTEIN 7)		 5k5a PARB DOMAIN PROTEIN
NUCLEASE
(Sulfolobus
solfataricus) 		5 / 11 ILE B 201
ALA B 171
GLU B 158
ASN B 202
TYR B 226
 None
 1.08A 1n6cA-5k5aB:
undetectable		 1n6cA-5k5aB:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_C_BEZC505_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5k5a PARB DOMAIN PROTEIN
NUCLEASE
(Sulfolobus
solfataricus) 		4 / 6 ILE B 201
GLU B 159
PHE B 223
ARG B 194
 None
 1.31A 1oniA-5k5aB:
undetectable
1oniC-5k5aB:
undetectable		 1oniA-5k5aB:
17.49
1oniC-5k5aB:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5k5a PARB DOMAIN PROTEIN
NUCLEASE
(Sulfolobus
solfataricus) 		4 / 7 PHE B  26
ARG B  91
ALA B  94
ILE B 120
 None
 0.98A 1oniD-5k5aB:
undetectable
1oniF-5k5aB:
undetectable		 1oniD-5k5aB:
17.49
1oniF-5k5aB:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_G_BEZG513_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5k5a PARB DOMAIN PROTEIN
NUCLEASE
(Sulfolobus
solfataricus) 		4 / 5 PHE B 223
ARG B 194
ILE B 201
GLU B 159
 None
 1.14A 1oniG-5k5aB:
undetectable
1oniH-5k5aB:
undetectable		 1oniG-5k5aB:
17.49
1oniH-5k5aB:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5k5a PARB DOMAIN PROTEIN
NUCLEASE
(Sulfolobus
solfataricus) 		5 / 11 LEU B 178
ALA B 171
ALA B 197
MET B 196
LEU B 114
 None
 1.30A 3bszE-5k5aB:
undetectable		 3bszE-5k5aB:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5k5a PARB DOMAIN PROTEIN
NUCLEASE
(Sulfolobus
solfataricus) 		3 / 3 ARG B 224
ARG B 256
LYS B 257
 None
 1.49A 3w1wA-5k5aB:
undetectable
3w1wB-5k5aB:
undetectable		 3w1wA-5k5aB:
20.89
3w1wB-5k5aB:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5k5a PARB DOMAIN PROTEIN
NUCLEASE
(Sulfolobus
solfataricus) 		5 / 11 ILE B 201
ALA B 171
GLU B 158
ASN B 202
TYR B 226
 None
 1.05A 4e47A-5k5aB:
undetectable		 4e47A-5k5aB:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5k5a PARB DOMAIN PROTEIN
NUCLEASE
(Sulfolobus
solfataricus) 		5 / 11 ILE B 201
ALA B 171
GLU B 158
ASN B 202
TYR B 226
 None
 1.08A 4e47B-5k5aB:
undetectable		 4e47B-5k5aB:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5k5a PARB DOMAIN PROTEIN
NUCLEASE
(Sulfolobus
solfataricus) 		5 / 11 ILE B 201
ALA B 171
GLU B 158
ASN B 202
TYR B 226
 None
 1.06A 4e47C-5k5aB:
undetectable		 4e47C-5k5aB:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_D_SAMD800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5k5a PARB DOMAIN PROTEIN
NUCLEASE
(Sulfolobus
solfataricus) 		5 / 10 ILE B 201
ALA B 171
GLU B 158
ASN B 202
TYR B 226
 None
 1.11A 4e47D-5k5aB:
undetectable		 4e47D-5k5aB:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_1
(METHYLTRANSFERASE
NSUN4)		 5k5a PARB DOMAIN PROTEIN
NUCLEASE
(Sulfolobus
solfataricus) 		3 / 3 ASP B  57
ARG B  56
ASP B  23
 None
 0.79A 4fp9C-5k5aB:
undetectable		 4fp9C-5k5aB:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_1
(METHYLTRANSFERASE
NSUN4)		 5k5a PARB DOMAIN PROTEIN
NUCLEASE
(Sulfolobus
solfataricus) 		3 / 3 ASP B  57
ARG B  56
ASP B  23
 None
 0.77A 4fp9F-5k5aB:
undetectable		 4fp9F-5k5aB:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J83_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5k5a PARB DOMAIN PROTEIN
NUCLEASE
(Sulfolobus
solfataricus) 		5 / 11 ILE B 201
ALA B 171
GLU B 158
ASN B 202
TYR B 226
 None
 1.11A 4j83A-5k5aB:
undetectable		 4j83A-5k5aB:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5k5a PARB DOMAIN PROTEIN
NUCLEASE
(Sulfolobus
solfataricus) 		5 / 11 ILE B 201
ALA B 171
GLU B 158
ASN B 202
TYR B 226
 None
 1.06A 4jdsA-5k5aB:
undetectable		 4jdsA-5k5aB:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5k5a PARB DOMAIN PROTEIN
NUCLEASE
(Sulfolobus
solfataricus) 		5 / 11 ILE B 201
ALA B 171
GLU B 158
ASN B 202
TYR B 226
 None
 1.05A 4jdsB-5k5aB:
undetectable		 4jdsB-5k5aB:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5k5a PARB DOMAIN PROTEIN
NUCLEASE
(Sulfolobus
solfataricus) 		5 / 11 ILE B 201
ALA B 171
GLU B 158
ASN B 202
TYR B 226
 None
 1.06A 4jdsC-5k5aB:
undetectable		 4jdsC-5k5aB:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_D_SAMD401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5k5a PARB DOMAIN PROTEIN
NUCLEASE
(Sulfolobus
solfataricus) 		5 / 11 ILE B 201
ALA B 171
GLU B 158
ASN B 202
TYR B 226
 None
 1.10A 4jdsD-5k5aB:
undetectable		 4jdsD-5k5aB:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5k5a PARB DOMAIN PROTEIN
NUCLEASE
(Sulfolobus
solfataricus) 		5 / 12 ILE B 201
ALA B 171
GLU B 158
ASN B 202
TYR B 226
 None
 1.08A 4jlgA-5k5aB:
undetectable		 4jlgA-5k5aB:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5k5a PARB DOMAIN PROTEIN
NUCLEASE
(Sulfolobus
solfataricus) 		5 / 11 ILE B 201
ALA B 171
GLU B 158
ASN B 202
TYR B 226
 None
 1.11A 4jlgB-5k5aB:
undetectable		 4jlgB-5k5aB:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5k5a PARB DOMAIN PROTEIN
NUCLEASE
(Sulfolobus
solfataricus) 		4 / 5 ILE B 120
LEU B 116
ASP B  62
GLU B  25
 None
 0.96A 4nkxB-5k5aB:
undetectable		 4nkxB-5k5aB:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5k5a PARB DOMAIN PROTEIN
NUCLEASE
(Sulfolobus
solfataricus) 		5 / 11 ILE B 201
ALA B 171
GLU B 158
ASN B 202
TYR B 226
 None
 1.09A 5ayfA-5k5aB:
undetectable		 5ayfA-5k5aB:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)		 5k5a PARB DOMAIN PROTEIN
NUCLEASE
(Sulfolobus
solfataricus) 		5 / 12 LEU B 207
LEU B 219
PHE B 117
ALA B 121
LEU B 178
 None
 1.06A 5iepA-5k5aB:
undetectable		 5iepA-5k5aB:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5k5a PARB DOMAIN PROTEIN
NUCLEASE
(Sulfolobus
solfataricus) 		4 / 6 GLY B 103
ASN B 102
ARG B 106
ARG B 105
 None
 1.19A 6dwdA-5k5aB:
undetectable
6dwdC-5k5aB:
undetectable		 6dwdA-5k5aB:
21.56
6dwdC-5k5aB:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5k5a PARB DOMAIN PROTEIN
NUCLEASE
(Sulfolobus
solfataricus) 		4 / 5 GLY B 103
ASN B 102
ARG B 106
ARG B 105
 None
 1.18A 6dwdB-5k5aB:
undetectable
6dwdD-5k5aB:
undetectable		 6dwdB-5k5aB:
21.56
6dwdD-5k5aB:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5k5a PARB DOMAIN PROTEIN
NUCLEASE
(Sulfolobus
solfataricus) 		4 / 5 ARG B 106
ARG B 105
GLY B 103
ASN B 102
 None
 1.10A 6dwjB-5k5aB:
undetectable
6dwjD-5k5aB:
undetectable		 6dwjB-5k5aB:
21.56
6dwjD-5k5aB:
21.56