SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5k5m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3003_1
(SERUM ALBUMIN)		 5k5m RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		3 / 4 LYS A 375
ALA A 378
MET A 552
 None
 1.07A 1hk3A-5k5mA:
2.4		 1hk3A-5k5mA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 5k5m RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		3 / 3 PHE A 483
VAL A 435
TRP A 432
 None
 0.88A 2cc8A-5k5mA:
undetectable		 2cc8A-5k5mA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 5k5m RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		3 / 3 PHE A 483
VAL A 435
TRP A 432
 None
 0.87A 2ccbA-5k5mA:
undetectable		 2ccbA-5k5mA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		 5k5m RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		5 / 9 GLY A 506
SER A 505
LEU A 655
SER A 503
LEU A 381
 None
 1.42A 2j2pB-5k5mA:
undetectable
2j2pC-5k5mA:
undetectable		 2j2pB-5k5mA:
15.85
2j2pC-5k5mA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5k5m RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		5 / 12 ALA A 866
VAL A 870
ALA A 782
THR A 329
LEU A 774
 None
 1.14A 2japA-5k5mA:
undetectable		 2japA-5k5mA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5k5m RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		5 / 12 ALA A 866
VAL A 870
ALA A 782
THR A 329
LEU A 774
 None
 1.15A 2japB-5k5mA:
undetectable		 2japB-5k5mA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5k5m RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		5 / 12 ALA A 866
VAL A 870
ALA A 782
THR A 329
LEU A 774
 None
 1.13A 2japC-5k5mA:
undetectable		 2japC-5k5mA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5k5m RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		5 / 12 ALA A 866
VAL A 870
ALA A 782
THR A 329
LEU A 774
 None
 1.13A 2japD-5k5mA:
undetectable		 2japD-5k5mA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 5k5m RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		5 / 12 ILE A 735
ALA A 775
TYR A 766
LEU A 734
LEU A 839
 None
 1.02A 2rctA-5k5mA:
undetectable		 2rctA-5k5mA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 5k5m RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		3 / 3 PHE A 483
VAL A 435
TRP A 432
 None
 0.87A 2vx9A-5k5mA:
1.6		 2vx9A-5k5mA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 5k5m RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		3 / 3 GLY A 848
TRP A 332
VAL A 335
 None
 0.75A 3n62B-5k5mA:
undetectable		 3n62B-5k5mA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 5k5m RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		3 / 3 GLY A 848
TRP A 332
VAL A 335
 None
 0.71A 3n65B-5k5mA:
undetectable		 3n65B-5k5mA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 5k5m RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		3 / 3 GLY A 848
TRP A 332
VAL A 335
 None
 0.73A 3n66B-5k5mA:
undetectable		 3n66B-5k5mA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 5k5m RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		6 / 9 ASP A 539
THR A 606
ASN A 610
GLY A 662
ASP A 663
ASP A 664
 None
 1.21A 3sfuA-5k5mA:
19.9		 3sfuA-5k5mA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_B_RBVB601_1
(RNA POLYMERASE)		 5k5m RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		5 / 9 ASP A 539
ASN A 610
GLY A 662
ASP A 663
ASP A 664
 None
 1.00A 3sfuB-5k5mA:
21.1		 3sfuB-5k5mA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 5k5m RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		5 / 11 ASP A 539
THR A 606
ASN A 610
GLY A 662
ASP A 663
 None
 1.17A 3sfuC-5k5mA:
20.3		 3sfuC-5k5mA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 5k5m RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		4 / 6 GLU A 560
GLY A 559
LEU A 443
GLU A 566
 None
 1.16A 3w9tF-5k5mA:
undetectable		 3w9tF-5k5mA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_1
(WBDD)		 5k5m RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		4 / 6 GLN A 760
ASP A 808
GLU A 831
LEU A 764
 None
 1.27A 4ax8A-5k5mA:
undetectable		 4ax8A-5k5mA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_1
(WBDD)		 5k5m RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		4 / 6 GLN A 364
ARG A 362
ASP A 683
GLU A 616
 None
 1.33A 4azvA-5k5mA:
undetectable		 4azvA-5k5mA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HOJ_A_ACTA303_0
(REGF PROTEIN)		 5k5m RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		4 / 5 VAL A 628
MET A 623
GLU A 624
LEU A 373
 None
 1.38A 4hojA-5k5mA:
undetectable		 4hojA-5k5mA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 5k5m RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		5 / 12 ILE A 735
ALA A 775
TYR A 766
LEU A 734
LEU A 839
 None
 1.19A 4qynA-5k5mA:
undetectable		 4qynA-5k5mA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 5k5m RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		5 / 12 ILE A 735
ALA A 775
TYR A 766
LEU A 734
LEU A 839
 None
 1.03A 4qzuC-5k5mA:
undetectable		 4qzuC-5k5mA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 5k5m RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		3 / 3 ARG A 482
TYR A 573
GLU A 485
 None
 0.58A 4zzbE-5k5mA:
undetectable		 4zzbE-5k5mA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 5k5m RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		3 / 3 TRP A 478
MET A 477
ASN A 453
 None
 1.39A 5uc1A-5k5mA:
undetectable		 5uc1A-5k5mA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5k5m RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		3 / 3 GLY A 848
TRP A 332
VAL A 335
 None
 0.69A 5vuoB-5k5mA:
undetectable		 5vuoB-5k5mA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11802_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
UL4
RIBOSOMAL PROTEIN
UL15
RIBOSOMAL PROTEIN
EL15)		 5k5m RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		3 / 3 ARG A 770
LYS A 719
ARG A 856
 None
 1.42A 6az3C-5k5mA:
undetectable
6az3L-5k5mA:
undetectable
6az3M-5k5mA:
undetectable		 6az3C-5k5mA:
9.17
6az3L-5k5mA:
10.14
6az3M-5k5mA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5k5m RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		4 / 6 GLN A 622
PRO A 669
ALA A 680
THR A 679
 None
 1.06A 6cduB-5k5mA:
undetectable
6cduC-5k5mA:
undetectable		 6cduB-5k5mA:
19.72
6cduC-5k5mA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5k5m RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		4 / 7 GLN A 622
PRO A 669
ALA A 680
THR A 679
 None
 0.94A 6cduH-5k5mA:
undetectable
6cduI-5k5mA:
undetectable		 6cduH-5k5mA:
19.72
6cduI-5k5mA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)		 5k5m RNA DEPENDENT RNA
POLYMERASE
(Dengue
virus) 		4 / 8 ARG A 396
GLY A 480
LEU A 479
ALA A 425
 None
 0.77A 6mdqA-5k5mA:
2.4		 6mdqA-5k5mA:
7.09