SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5k5t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 5k5t EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR
(Homo
sapiens) 		6 / 12 PHE A 226
ILE A 235
TRP A 206
VAL A 268
ILE A 259
LYS A 291
 None
 1.47A 1epbA-5k5tA:
undetectable		 1epbA-5k5tA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5k5t EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR
(Homo
sapiens) 		5 / 12 ILE A 292
ILE A 528
ILE A 523
LEU A 521
ILE A 491
 None
 0.91A 1oipA-5k5tA:
undetectable		 1oipA-5k5tA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_A_STRA301_1
(MINERALOCORTICOID
RECEPTOR)		 5k5t EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR
(Homo
sapiens) 		5 / 12 ASN A 155
LEU A 157
ALA A 154
GLN A 164
LEU A  37
 None
 1.23A 2aa5A-5k5tA:
undetectable		 2aa5A-5k5tA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)		 5k5t EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR
(Homo
sapiens) 		5 / 12 ASN A 155
LEU A 157
ALA A 154
GLN A 164
LEU A  37
 None
 1.23A 2aa5B-5k5tA:
undetectable		 2aa5B-5k5tA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_A_STRA401_1
(MINERALOCORTICOID
RECEPTOR)		 5k5t EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR
(Homo
sapiens) 		5 / 12 ASN A 155
LEU A 157
ALA A 154
GLN A 164
LEU A  37
 None
 1.27A 2aa6A-5k5tA:
undetectable		 2aa6A-5k5tA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_A_STRA401_1
(MINERALOCORTICOID
RECEPTOR)		 5k5t EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR
(Homo
sapiens) 		5 / 12 LEU A 156
ASN A 155
LEU A 157
ALA A 154
GLN A 164
 None
 1.39A 2aa6A-5k5tA:
undetectable		 2aa6A-5k5tA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_B_STRB402_1
(MINERALOCORTICOID
RECEPTOR)		 5k5t EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR
(Homo
sapiens) 		5 / 12 ASN A 155
LEU A 157
ALA A 154
GLN A 164
LEU A  37
 None
 1.26A 2aa6B-5k5tA:
undetectable		 2aa6B-5k5tA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5k5t EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR
(Homo
sapiens) 		4 / 6 ILE A 427
ILE A 327
TYR A 418
LEU A 464
 None
 0.89A 3adsA-5k5tA:
undetectable		 3adsA-5k5tA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 5k5t EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR
(Homo
sapiens) 		3 / 3 SER A 591
GLU A 567
ASP A 570
 None
 0.78A 3bwmA-5k5tA:
4.5		 3bwmA-5k5tA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 5k5t EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR
(Homo
sapiens) 		3 / 3 SER A 591
GLU A 567
ASP A 570
 None
 0.76A 3bwyA-5k5tA:
3.4		 3bwyA-5k5tA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		 5k5t EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR
(Homo
sapiens) 		5 / 12 LEU A  34
GLY A  35
ILE A 427
ALA A 457
LEU A 464
 None
 1.02A 3gwvA-5k5tA:
undetectable		 3gwvA-5k5tA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 5k5t EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR
(Homo
sapiens) 		5 / 12 GLY A  35
LEU A  34
ARG A  96
GLN A  27
ILE A 139
 None
 1.00A 3gwwA-5k5tA:
undetectable		 3gwwA-5k5tA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 5k5t EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR
(Homo
sapiens) 		5 / 10 ASP A 199
PHE A 226
VAL A 268
ILE A 523
PHE A 320
 None
 1.28A 3ihzA-5k5tA:
undetectable		 3ihzA-5k5tA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KIV_A_ACAA100_1
(APOLIPOPROTEIN)		 5k5t EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR
(Homo
sapiens) 		4 / 7 ARG A 185
ASP A 484
ASP A 480
PHE A 183
 None
 1.46A 3kivA-5k5tA:
undetectable		 3kivA-5k5tA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5k5t EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR
(Homo
sapiens) 		4 / 6 VAL A 313
VAL A 269
ILE A 305
ARG A 286
 None
 0.88A 3ms9A-5k5tA:
undetectable		 3ms9A-5k5tA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5k5t EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR
(Homo
sapiens) 		4 / 6 VAL A 313
VAL A 269
ILE A 305
ARG A 286
 None
 0.89A 3mssA-5k5tA:
undetectable		 3mssA-5k5tA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5k5t EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR
(Homo
sapiens) 		4 / 6 VAL A 313
VAL A 269
ILE A 305
ARG A 286
 None
 0.88A 3mssC-5k5tA:
undetectable		 3mssC-5k5tA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 5k5t EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR
(Homo
sapiens) 		4 / 6 VAL A 313
VAL A 269
ILE A 305
ARG A 286
 None
 0.97A 3pyyA-5k5tA:
undetectable		 3pyyA-5k5tA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5k5t EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR
(Homo
sapiens) 		3 / 3 HIS A  41
SER A  57
GLU A  59
 None
 0.92A 3s8pA-5k5tA:
undetectable		 3s8pA-5k5tA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5k5t EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR
(Homo
sapiens) 		5 / 12 SER A 540
GLY A 316
SER A 531
ILE A 528
VAL A 508
 None
 1.16A 4dx5B-5k5tA:
undetectable		 4dx5B-5k5tA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ3_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 5k5t EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR
(Homo
sapiens) 		5 / 10 ASP A 199
ARG A 233
PHE A 226
ILE A 523
PHE A 320
 None
 1.38A 4dz3A-5k5tA:
undetectable		 4dz3A-5k5tA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5k5t EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR
(Homo
sapiens) 		5 / 12 LEU A 157
VAL A 141
MET A  74
PHE A  38
THR A 100
 None
None
None
None
CA  A 701 (-3.2A)
 1.27A 4iaqA-5k5tA:
undetectable		 4iaqA-5k5tA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_A_SVRA301_1
(NUCLEOCAPSID PROTEIN)		 5k5t EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR
(Homo
sapiens) 		5 / 11 ARG A 185
ALA A 168
VAL A 420
MET A  74
ILE A 427
 None
 1.30A 4j4vA-5k5tA:
undetectable		 4j4vA-5k5tA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5k5t EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR
(Homo
sapiens) 		4 / 5 LEU A  88
PRO A  89
LEU A  91
ILE A  32
 None
 0.92A 4klrA-5k5tA:
4.4		 4klrA-5k5tA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 5k5t EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR
(Homo
sapiens) 		4 / 5 GLY A 219
ALA A 213
GLY A 222
PRO A 221
 None
 0.88A 4u9uA-5k5tA:
3.0		 4u9uA-5k5tA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 5k5t EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR
(Homo
sapiens) 		5 / 12 PHE A 347
LEU A  71
GLY A  94
LEU A  34
VAL A 420
 None
 1.17A 4wnwA-5k5tA:
undetectable		 4wnwA-5k5tA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 5k5t EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR
(Homo
sapiens) 		3 / 3 SER A 591
GLU A 567
ASP A 570
 None
 0.83A 4xudA-5k5tA:
3.6		 4xudA-5k5tA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5k5t EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR
(Homo
sapiens) 		5 / 12 ILE A  78
GLY A  94
TYR A 425
ALA A  77
MET A  74
 None
 1.26A 5n0xB-5k5tA:
2.5		 5n0xB-5k5tA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_1
(PROTEASE)		 5k5t EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR
(Homo
sapiens) 		5 / 12 VAL A 165
ILE A  81
LEU A 184
VAL A 420
VAL A 142
 None
 1.07A 6dh0B-5k5tA:
undetectable		 6dh0B-5k5tA:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_1
(PEPTIDYLPROLYL
ISOMERASE)		 5k5t EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR
(Homo
sapiens) 		5 / 10 ASP A 199
ARG A 233
PHE A 226
ILE A 523
PHE A 320
 None
 1.39A 6mkeC-5k5tA:
undetectable		 6mkeC-5k5tA:
9.05