SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5k5w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 5k5w LIMITING
CO2-INDUCIBLE
PROTEIN LCIB
(Chlamydomonas
reinhardtii) 		5 / 8 CYH A 120
ASP A 122
HIS A 180
CYH A 204
GLY A 205
 ZN  A 500 (-2.3A)
ZN  A 500 ( 4.9A)
ZN  A 500 (-3.3A)
ZN  A 500 (-2.3A)
None
 0.49A 1ekjA-5k5wA:
11.8
1ekjB-5k5wA:
11.8		 1ekjA-5k5wA:
22.74
1ekjB-5k5wA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 5k5w LIMITING
CO2-INDUCIBLE
PROTEIN LCIB
(Chlamydomonas
reinhardtii) 		5 / 8 CYH A 120
ASP A 122
HIS A 180
CYH A 204
GLY A 205
 ZN  A 500 (-2.3A)
ZN  A 500 ( 4.9A)
ZN  A 500 (-3.3A)
ZN  A 500 (-2.3A)
None
 0.51A 1ekjA-5k5wA:
10.1
1ekjB-5k5wA:
11.4		 1ekjA-5k5wA:
22.74
1ekjB-5k5wA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 5k5w LIMITING
CO2-INDUCIBLE
PROTEIN LCIB
(Chlamydomonas
reinhardtii) 		4 / 7 CYH A 120
ASP A 122
HIS A 180
GLY A 205
 ZN  A 500 (-2.3A)
ZN  A 500 ( 4.9A)
ZN  A 500 (-3.3A)
None
 0.54A 1ekjE-5k5wA:
11.4
1ekjF-5k5wA:
11.4		 1ekjE-5k5wA:
22.74
1ekjF-5k5wA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 5k5w LIMITING
CO2-INDUCIBLE
PROTEIN LCIB
(Chlamydomonas
reinhardtii) 		5 / 8 CYH A 120
ASP A 122
HIS A 180
CYH A 204
GLY A 205
 ZN  A 500 (-2.3A)
ZN  A 500 ( 4.9A)
ZN  A 500 (-3.3A)
ZN  A 500 (-2.3A)
None
 0.48A 1ekjG-5k5wA:
12.1
1ekjH-5k5wA:
11.2		 1ekjG-5k5wA:
22.74
1ekjH-5k5wA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 5k5w LIMITING
CO2-INDUCIBLE
PROTEIN LCIB
(Chlamydomonas
reinhardtii) 		5 / 8 CYH A 120
ASP A 122
HIS A 180
CYH A 204
GLY A 205
 ZN  A 500 (-2.3A)
ZN  A 500 ( 4.9A)
ZN  A 500 (-3.3A)
ZN  A 500 (-2.3A)
None
 1.20A 1ekjG-5k5wA:
12.1
1ekjH-5k5wA:
11.2		 1ekjG-5k5wA:
22.74
1ekjH-5k5wA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 5k5w LIMITING
CO2-INDUCIBLE
PROTEIN LCIB
(Chlamydomonas
reinhardtii) 		4 / 6 CYH A 120
ASP A 122
HIS A 180
CYH A 204
 ZN  A 500 (-2.3A)
ZN  A 500 ( 4.9A)
ZN  A 500 (-3.3A)
ZN  A 500 (-2.3A)
 0.50A 1ekjG-5k5wA:
12.1
1ekjH-5k5wA:
11.3		 1ekjG-5k5wA:
22.74
1ekjH-5k5wA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 5k5w LIMITING
CO2-INDUCIBLE
PROTEIN LCIB
(Chlamydomonas
reinhardtii) 		5 / 9 GLY A 146
GLU A 235
ILE A 270
ALA A 266
PHE A 178
 ZN  A 500 ( 4.5A)
None
None
None
None
 1.07A 2drdA-5k5wA:
undetectable		 2drdA-5k5wA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_A_CUA1599_0
(NITROUS OXIDE
REDUCTASE)		 5k5w LIMITING
CO2-INDUCIBLE
PROTEIN LCIB
(Chlamydomonas
reinhardtii) 		3 / 3 CYH A 120
CYH A 204
HIS A 180
 ZN  A 500 (-2.3A)
ZN  A 500 (-2.3A)
ZN  A 500 (-3.3A)
 0.84A 2iwkA-5k5wA:
undetectable		 2iwkA-5k5wA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1022_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 5k5w LIMITING
CO2-INDUCIBLE
PROTEIN LCIB
(Chlamydomonas
reinhardtii) 		3 / 3 CYH A 120
CYH A 204
HIS A 180
 ZN  A 500 (-2.3A)
ZN  A 500 (-2.3A)
ZN  A 500 (-3.3A)
 0.86A 3dtuB-5k5wA:
undetectable		 3dtuB-5k5wA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD3_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 5k5w LIMITING
CO2-INDUCIBLE
PROTEIN LCIB
(Chlamydomonas
reinhardtii) 		3 / 3 CYH A 120
CYH A 204
HIS A 180
 ZN  A 500 (-2.3A)
ZN  A 500 (-2.3A)
ZN  A 500 (-3.3A)
 0.84A 3dtuD-5k5wA:
undetectable		 3dtuD-5k5wA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 5k5w LIMITING
CO2-INDUCIBLE
PROTEIN LCIB
(Chlamydomonas
reinhardtii) 		7 / 10 CYH A 120
ASP A 122
HIS A 180
CYH A 204
GLY A 205
ALA A 206
ALA A 209
 ZN  A 500 (-2.3A)
ZN  A 500 ( 4.9A)
ZN  A 500 (-3.3A)
ZN  A 500 (-2.3A)
None
None
None
 0.46A 3ucjA-5k5wA:
12.6		 3ucjA-5k5wA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 5k5w LIMITING
CO2-INDUCIBLE
PROTEIN LCIB
(Chlamydomonas
reinhardtii) 		7 / 10 CYH A 120
ASP A 122
HIS A 180
CYH A 204
GLY A 205
ALA A 206
ALA A 209
 ZN  A 500 (-2.3A)
ZN  A 500 ( 4.9A)
ZN  A 500 (-3.3A)
ZN  A 500 (-2.3A)
None
None
None
 0.47A 3ucjB-5k5wA:
13.3		 3ucjB-5k5wA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 5k5w LIMITING
CO2-INDUCIBLE
PROTEIN LCIB
(Chlamydomonas
reinhardtii) 		4 / 6 HIS A 298
HIS A 180
LEU A 128
THR A 125
 None
ZN  A 500 (-3.3A)
None
None
 1.03A 5ogjA-5k5wA:
undetectable		 5ogjA-5k5wA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_B_ACTB305_0
(CARBONIC ANHYDRASE
13)		 5k5w LIMITING
CO2-INDUCIBLE
PROTEIN LCIB
(Chlamydomonas
reinhardtii) 		4 / 6 HIS A 298
HIS A 180
LEU A 128
THR A 125
 None
ZN  A 500 (-3.3A)
None
None
 1.03A 5ogjB-5k5wA:
undetectable		 5ogjB-5k5wA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 5k5w LIMITING
CO2-INDUCIBLE
PROTEIN LCIB
(Chlamydomonas
reinhardtii) 		4 / 5 HIS A 298
HIS A 180
LEU A 128
THR A 125
 None
ZN  A 500 (-3.3A)
None
None
 1.03A 5ohhA-5k5wA:
undetectable		 5ohhA-5k5wA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_B_ACTB311_0
(CARBONIC ANHYDRASE
13)		 5k5w LIMITING
CO2-INDUCIBLE
PROTEIN LCIB
(Chlamydomonas
reinhardtii) 		4 / 6 HIS A 298
HIS A 180
LEU A 128
THR A 125
 None
ZN  A 500 (-3.3A)
None
None
 1.03A 5ohhB-5k5wA:
undetectable		 5ohhB-5k5wA:
20.25