SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5k5z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5k5z PARA
(Sulfolobus
sp.
NOB8H2) 		5 / 9 ALA A 170
ASP A 165
ILE A   8
ILE A 162
THR A 167
 None
 1.31A 1j3jB-5k5zA:
undetectable		 1j3jB-5k5zA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)		 5k5z PARA
(Sulfolobus
sp.
NOB8H2) 		4 / 7 ASP A 141
MET A  44
ASP A  39
ASP A  41
 MG  A 702 (-3.0A)
None
None
MG  A 702 ( 3.4A)
 1.23A 1t03A-5k5zA:
undetectable		 1t03A-5k5zA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 5k5z PARA
(Sulfolobus
sp.
NOB8H2) 		4 / 8 THR A 142
VAL A  15
GLY A  16
ILE A 162
 None
ANP  A 701 (-4.1A)
ANP  A 701 (-3.2A)
None
 0.77A 2a1mB-5k5zA:
undetectable		 2a1mB-5k5zA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 5k5z PARA
(Sulfolobus
sp.
NOB8H2) 		4 / 8 LEU A 182
ASN A  10
HIS A   9
ALA A 181
 None
 1.02A 2bnnA-5k5zA:
undetectable
2bnnB-5k5zA:
undetectable		 2bnnA-5k5zA:
22.96
2bnnB-5k5zA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KQE_A_ADNA1002_1
(APRATAXIN AND
PNK-LIKE FACTOR)		 5k5z PARA
(Sulfolobus
sp.
NOB8H2) 		4 / 5 TYR A 159
SER A 157
TYR A 197
ARG A 199
 None
 1.34A 2kqeA-5k5zA:
undetectable		 2kqeA-5k5zA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 5k5z PARA
(Sulfolobus
sp.
NOB8H2) 		3 / 3 LEU A 161
GLU A 306
ILE A 303
 None
 0.56A 3czhA-5k5zA:
undetectable		 3czhA-5k5zA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5k5z PARA
(Sulfolobus
sp.
NOB8H2) 		5 / 12 ILE A 107
THR A 149
LEU A 139
ILE A  38
THR A  21
 None
 1.25A 3em0B-5k5zA:
undetectable		 3em0B-5k5zA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5k5z PARA
(Sulfolobus
sp.
NOB8H2) 		4 / 6 VAL A   5
ILE A 124
ILE A 138
LEU A 139
 None
 0.71A 3hegA-5k5zA:
undetectable		 3hegA-5k5zA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5k5z PARA
(Sulfolobus
sp.
NOB8H2) 		5 / 9 ILE A 204
LEU A 161
ILE A 200
MET A 174
ILE A 237
 None
 1.04A 3zosA-5k5zA:
undetectable		 3zosA-5k5zA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 5k5z PARA
(Sulfolobus
sp.
NOB8H2) 		5 / 12 GLY A  14
GLY A  13
LEU A 264
SER A 262
ASP A  41
 ANP  A 701 (-3.5A)
ANP  A 701 ( 3.5A)
None
ANP  A 701 (-3.2A)
MG  A 702 ( 3.4A)
 0.96A 4fp9A-5k5zA:
undetectable		 4fp9A-5k5zA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 5k5z PARA
(Sulfolobus
sp.
NOB8H2) 		5 / 12 GLY A  14
GLY A  13
LEU A 264
SER A 262
ASP A  41
 ANP  A 701 (-3.5A)
ANP  A 701 ( 3.5A)
None
ANP  A 701 (-3.2A)
MG  A 702 ( 3.4A)
 0.97A 4fp9C-5k5zA:
undetectable		 4fp9C-5k5zA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 5k5z PARA
(Sulfolobus
sp.
NOB8H2) 		5 / 12 GLY A  14
GLY A  13
LEU A 264
SER A 262
ASP A  41
 ANP  A 701 (-3.5A)
ANP  A 701 ( 3.5A)
None
ANP  A 701 (-3.2A)
MG  A 702 ( 3.4A)
 0.97A 4fp9F-5k5zA:
undetectable		 4fp9F-5k5zA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOV_A_KOVA204_1
(UNCHARACTERIZED
PROTEIN)		 5k5z PARA
(Sulfolobus
sp.
NOB8H2) 		5 / 12 TYR A 238
PRO A 239
GLY A 202
ILE A 204
LEU A 216
 None
 1.44A 4kovA-5k5zA:
undetectable		 4kovA-5k5zA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 5k5z PARA
(Sulfolobus
sp.
NOB8H2) 		5 / 12 LEU A  36
ALA A   3
ALA A 156
ILE A 140
ILE A 124
 None
 1.03A 4o2bB-5k5zA:
3.2		 4o2bB-5k5zA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 5k5z PARA
(Sulfolobus
sp.
NOB8H2) 		5 / 12 PRO A 249
TYR A 241
ALA A 244
GLY A 202
LEU A 201
 None
 1.05A 4oaeA-5k5zA:
undetectable		 4oaeA-5k5zA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)		 5k5z PARA
(Sulfolobus
sp.
NOB8H2) 		5 / 12 LEU A  36
ALA A   3
ALA A 156
ILE A 140
ILE A 124
 None
 1.05A 5mioB-5k5zA:
3.8		 5mioB-5k5zA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 5k5z PARA
(Sulfolobus
sp.
NOB8H2) 		5 / 12 LEU A 187
ILE A 186
LEU A 232
LEU A 227
LEU A 178
 None
 1.23A 5nfjC-5k5zA:
undetectable		 5nfjC-5k5zA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 5k5z PARA
(Sulfolobus
sp.
NOB8H2) 		4 / 6 GLN A  48
LEU A  60
MET A 111
PRO A 101
 None
 1.20A 6brdB-5k5zA:
undetectable		 6brdB-5k5zA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 5k5z PARA
(Sulfolobus
sp.
NOB8H2) 		5 / 9 LEU A 139
THR A  21
ILE A  24
VAL A 307
ILE A   6
 None
 1.30A 6ef6A-5k5zA:
undetectable		 6ef6A-5k5zA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5k5z PARA
(Sulfolobus
sp.
NOB8H2) 		4 / 8 SER A 106
SER A  71
PHE A  73
ASP A  41
 None
None
None
MG  A 702 ( 3.4A)
 1.01A 6fcbA-5k5zA:
undetectable		 6fcbA-5k5zA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)		 5k5z PARA
(Sulfolobus
sp.
NOB8H2) 		4 / 5 THR A 206
THR A 142
HIS A   9
GLY A 202
 None
 1.20A 6gbnC-5k5zA:
3.7		 6gbnC-5k5zA:
22.94