SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5k66'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 5k66 NTA1P
(Saccharomyces
cerevisiae) 		4 / 7 PHE A  64
SER A 187
ALA A 221
PHE A 401
 None
ASN  A 501 (-2.9A)
ASN  A 501 (-4.1A)
None
 1.19A 1fxvA-5k66A:
undetectable
1fxvB-5k66A:
undetectable		 1fxvA-5k66A:
17.48
1fxvB-5k66A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 5k66 NTA1P
(Saccharomyces
cerevisiae) 		4 / 7 SER A  18
ARG A 457
LEU A 180
GLU A 214
 None
 1.08A 2cdqB-5k66A:
undetectable		 2cdqB-5k66A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5k66 NTA1P
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 403
ASN A 390
THR A 399
TYR A 140
 None
None
None
ASN  A 501 ( 3.6A)
 0.86A 2yoeB-5k66A:
undetectable
2yoeC-5k66A:
undetectable		 2yoeB-5k66A:
20.56
2yoeC-5k66A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 5k66 NTA1P
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 263
SER A  42
ILE A 264
GLU A 444
 None
 0.96A 3a7eA-5k66A:
undetectable		 3a7eA-5k66A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 5k66 NTA1P
(Saccharomyces
cerevisiae) 		4 / 7 LEU A  66
ASP A  34
SER A  89
THR A  82
 None
 1.23A 3dzgB-5k66A:
undetectable		 3dzgB-5k66A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 5k66 NTA1P
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 382
SER A 372
GLN A 375
 None
 1.28A 3si7A-5k66A:
undetectable		 3si7A-5k66A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5k66 NTA1P
(Saccharomyces
cerevisiae) 		4 / 8 PRO A 219
VAL A 387
LEU A 215
ILE A 105
 None
 0.88A 3u5kA-5k66A:
undetectable		 3u5kA-5k66A:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5k66 NTA1P
(Saccharomyces
cerevisiae) 		4 / 7 PRO A 219
VAL A 387
LEU A 215
ILE A 105
 None
 0.84A 3u5kB-5k66A:
undetectable		 3u5kB-5k66A:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5k66 NTA1P
(Saccharomyces
cerevisiae) 		4 / 8 PRO A 219
VAL A 387
LEU A 215
ILE A 105
 None
 0.89A 3u5kC-5k66A:
undetectable		 3u5kC-5k66A:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5k66 NTA1P
(Saccharomyces
cerevisiae) 		4 / 8 PRO A 219
VAL A 387
LEU A 215
ILE A 105
 None
 0.89A 3u5kD-5k66A:
undetectable		 3u5kD-5k66A:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD507_1
(HEMOLYTIC LECTIN
CEL-III)		 5k66 NTA1P
(Saccharomyces
cerevisiae) 		4 / 5 GLU A 153
GLY A 154
TYR A 134
ASP A 189
 None
 1.41A 3w9tD-5k66A:
undetectable		 3w9tD-5k66A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5k66 NTA1P
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 193
ASN A 119
GLU A 150
GLU A 143
 None
None
None
ASN  A 501 ( 4.8A)
 1.02A 4mi4A-5k66A:
undetectable
4mi4C-5k66A:
undetectable		 4mi4A-5k66A:
15.94
4mi4C-5k66A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5k66 NTA1P
(Saccharomyces
cerevisiae) 		5 / 11 MET A 160
LEU A 215
LEU A  19
PRO A  56
VAL A  23
 None
 1.43A 4mk4B-5k66A:
undetectable		 4mk4B-5k66A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5k66 NTA1P
(Saccharomyces
cerevisiae) 		5 / 12 ASN A 151
GLY A 154
GLY A 185
PHE A 207
ILE A 186
 None
 1.06A 5vooF-5k66A:
undetectable		 5vooF-5k66A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5k66 NTA1P
(Saccharomyces
cerevisiae) 		4 / 8 PRO A 219
VAL A 387
LEU A 215
ILE A 105
 None
 0.87A 5y1yA-5k66A:
undetectable		 5y1yA-5k66A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5k66 NTA1P
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 442
GLY A 440
ASP A 289
ASN A 224
ILE A 400
 None
 1.16A 6exiA-5k66A:
undetectable		 6exiA-5k66A:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5k66 NTA1P
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 442
GLY A 440
ASP A 289
ASN A 224
ILE A 400
 None
 1.20A 6exiB-5k66A:
undetectable		 6exiB-5k66A:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5k66 NTA1P
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 442
GLY A 440
ASP A 289
ASN A 224
ILE A 400
 None
 1.15A 6exiC-5k66A:
undetectable
6exiD-5k66A:
undetectable		 6exiC-5k66A:
12.07
6exiD-5k66A:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5k66 NTA1P
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 442
GLY A 440
ASP A 289
ASN A 224
ILE A 400
 None
 1.17A 6exiC-5k66A:
undetectable
6exiD-5k66A:
undetectable		 6exiC-5k66A:
12.07
6exiD-5k66A:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 5k66 NTA1P
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 135
LYS A  84
TYR A 108
 None
 1.35A 6gnaA-5k66A:
undetectable		 6gnaA-5k66A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 5k66 NTA1P
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 135
LYS A  84
TYR A 108
 None
 1.35A 6gnbA-5k66A:
undetectable		 6gnbA-5k66A:
21.73