SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5k69'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 5k69 L,D-TRANSPEPTIDASE 2
(Mycobacterium
tuberculosis) 		3 / 3 TRP A 340
ALA A 344
VAL A 342
 6QR  A 503 (-3.8A)
None
None
 0.93A 1bdwA-5k69A:
undetectable
1bdwB-5k69A:
undetectable		 1bdwA-5k69A:
6.25
1bdwB-5k69A:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5k69 L,D-TRANSPEPTIDASE 2
(Mycobacterium
tuberculosis) 		5 / 10 GLY A 353
THR A 380
THR A 287
THR A 278
ALA A 257
 6QR  A 503 (-3.9A)
None
None
None
None
 1.40A 1gtnO-5k69A:
undetectable
1gtnP-5k69A:
undetectable		 1gtnO-5k69A:
11.27
1gtnP-5k69A:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5k69 L,D-TRANSPEPTIDASE 2
(Mycobacterium
tuberculosis) 		5 / 9 GLY A 353
THR A 380
THR A 287
THR A 278
ALA A 257
 6QR  A 503 (-3.9A)
None
None
None
None
 1.41A 1gtnQ-5k69A:
undetectable
1gtnR-5k69A:
undetectable		 1gtnQ-5k69A:
11.27
1gtnR-5k69A:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 5k69 L,D-TRANSPEPTIDASE 2
(Mycobacterium
tuberculosis) 		5 / 11 ASN A 356
MET A 280
GLY A 281
THR A 287
GLY A 332
 6QR  A 503 (-3.6A)
None
None
None
None
 1.11A 1jr1A-5k69A:
undetectable		 1jr1A-5k69A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 5k69 L,D-TRANSPEPTIDASE 2
(Mycobacterium
tuberculosis) 		5 / 10 ARG A 139
ASP A  85
GLY A 135
LEU A  62
ALA A 130
 None
 1.16A 1x7pA-5k69A:
undetectable
1x7pB-5k69A:
undetectable		 1x7pA-5k69A:
22.52
1x7pB-5k69A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5k69 L,D-TRANSPEPTIDASE 2
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 264
LEU A 355
MET A 280
SER A 329
LEU A 385
 None
 1.19A 2po7B-5k69A:
undetectable		 2po7B-5k69A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 5k69 L,D-TRANSPEPTIDASE 2
(Mycobacterium
tuberculosis) 		5 / 10 ILE A 374
ASP A 389
LEU A 391
GLY A 392
ASN A 395
 None
 1.16A 4eb4D-5k69A:
undetectable		 4eb4D-5k69A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 5k69 L,D-TRANSPEPTIDASE 2
(Mycobacterium
tuberculosis) 		4 / 7 ILE A 374
ASP A 389
LEU A 391
GLY A 392
 None
 0.78A 4iqqC-5k69A:
undetectable		 4iqqC-5k69A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 5k69 L,D-TRANSPEPTIDASE 2
(Mycobacterium
tuberculosis) 		4 / 7 PRO A 386
ASP A 389
SER A 331
SER A 329
 None
 1.19A 4k7gB-5k69A:
undetectable		 4k7gB-5k69A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5k69 L,D-TRANSPEPTIDASE 2
(Mycobacterium
tuberculosis) 		3 / 3 SER A  65
ASP A  76
ASP A 232
 None
 0.78A 4mwzA-5k69A:
undetectable		 4mwzA-5k69A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 5k69 L,D-TRANSPEPTIDASE 2
(Mycobacterium
tuberculosis) 		3 / 3 TYR A 308
TYR A 298
GLN A 327
 None
 0.85A 5jsdA-5k69A:
2.0
5jsdB-5k69A:
2.9		 5jsdA-5k69A:
22.80
5jsdB-5k69A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 5k69 L,D-TRANSPEPTIDASE 2
(Mycobacterium
tuberculosis) 		3 / 3 TYR A 308
TYR A 298
GLN A 327
 None
 0.85A 5jsdB-5k69A:
2.9
5jsdC-5k69A:
undetectable		 5jsdB-5k69A:
22.80
5jsdC-5k69A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 5k69 L,D-TRANSPEPTIDASE 2
(Mycobacterium
tuberculosis) 		4 / 8 SER A 351
THR A 278
THR A 380
THR A 287
 6QR  A 503 (-3.7A)
None
None
None
 1.02A 5l4eA-5k69A:
undetectable
5l4eB-5k69A:
undetectable
5l4eC-5k69A:
undetectable
5l4eD-5k69A:
undetectable
5l4eE-5k69A:
undetectable		 5l4eA-5k69A:
22.56
5l4eB-5k69A:
22.56
5l4eC-5k69A:
22.56
5l4eD-5k69A:
22.56
5l4eE-5k69A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 5k69 L,D-TRANSPEPTIDASE 2
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 374
ASP A 389
LEU A 391
GLY A 392
ASN A 395
 None
 1.02A 5x66A-5k69A:
undetectable
5x66B-5k69A:
undetectable		 5x66A-5k69A:
19.71
5x66B-5k69A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 5k69 L,D-TRANSPEPTIDASE 2
(Mycobacterium
tuberculosis) 		5 / 9 ILE A 374
ASP A 389
LEU A 391
GLY A 392
ASN A 395
 None
 1.03A 5x66C-5k69A:
undetectable		 5x66C-5k69A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5k69 L,D-TRANSPEPTIDASE 2
(Mycobacterium
tuberculosis) 		5 / 9 VAL A  79
GLY A 230
GLN A 117
THR A 145
VAL A  73
 None
 1.14A 6czmB-5k69A:
undetectable
6czmC-5k69A:
undetectable		 6czmB-5k69A:
21.78
6czmC-5k69A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5k69 L,D-TRANSPEPTIDASE 2
(Mycobacterium
tuberculosis) 		5 / 10 VAL A  79
GLY A 230
GLN A 117
THR A 145
VAL A  73
 None
 1.07A 6czmE-5k69A:
undetectable
6czmF-5k69A:
undetectable		 6czmE-5k69A:
21.78
6czmF-5k69A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 5k69 L,D-TRANSPEPTIDASE 2
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 211
ARG A 209
ASP A 393
 None
 0.84A 6d8pA-5k69A:
undetectable		 6d8pA-5k69A:
20.60