SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5k6o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_B_803B311_1
(ANTIGEN CD11A (P180))		 5k6o B-GLUCOSIDASE
(metagenome) 		4 / 7 VAL A 175
LEU A  75
VAL A  71
LEU A  34
 None
 0.74A 1cqpA-5k6oA:
undetectable
1cqpB-5k6oA:
undetectable		 1cqpA-5k6oA:
10.77
1cqpB-5k6oA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 5k6o B-GLUCOSIDASE
(metagenome) 		4 / 5 ARG A 538
ALA A 510
ASP A 540
GLY A 501
 GAL  A1000 (-4.4A)
GAL  A1000 ( 4.4A)
None
None
 1.04A 1e7bA-5k6oA:
undetectable		 1e7bA-5k6oA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 5k6o B-GLUCOSIDASE
(metagenome) 		4 / 5 ARG A 538
ALA A 510
ASP A 540
GLY A 501
 GAL  A1000 (-4.4A)
GAL  A1000 ( 4.4A)
None
None
 0.90A 1e7cA-5k6oA:
undetectable		 1e7cA-5k6oA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 5k6o B-GLUCOSIDASE
(metagenome) 		4 / 7 PHE A  45
SER A 130
ALA A 133
ILE A 134
 None
 1.07A 1fxhA-5k6oA:
undetectable
1fxhB-5k6oA:
undetectable		 1fxhA-5k6oA:
12.31
1fxhB-5k6oA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7G_A_BCZA801_0
(NEURAMINIDASE)		 5k6o B-GLUCOSIDASE
(metagenome) 		5 / 12 LEU A 582
ASP A 532
ARG A 538
GLU A 600
ARG A 597
 None
GAL  A1000 (-3.1A)
GAL  A1000 (-4.4A)
None
GAL  A1000 (-3.1A)
 1.44A 1l7gA-5k6oA:
undetectable		 1l7gA-5k6oA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 5k6o B-GLUCOSIDASE
(metagenome) 		4 / 7 TYR A 567
ASN A 550
HIS A 590
GLY A 181
 None
 1.25A 1mxgA-5k6oA:
2.7		 1mxgA-5k6oA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5k6o B-GLUCOSIDASE
(metagenome) 		5 / 12 ILE A 656
GLY A 257
ALA A 230
SER A 238
TYR A 657
 None
 1.34A 1nbhA-5k6oA:
3.0		 1nbhA-5k6oA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5k6o B-GLUCOSIDASE
(metagenome) 		5 / 12 ILE A 656
GLY A 257
ALA A 230
SER A 238
TYR A 657
 None
 1.34A 1nbhC-5k6oA:
undetectable		 1nbhC-5k6oA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5k6o B-GLUCOSIDASE
(metagenome) 		5 / 12 ILE A 656
GLY A 257
ALA A 230
SER A 238
TYR A 657
 None
 1.34A 1nbhD-5k6oA:
undetectable		 1nbhD-5k6oA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 5k6o B-GLUCOSIDASE
(metagenome) 		4 / 6 PHE A 602
ALA A 555
LEU A 554
ILE A 563
 None
 1.02A 1sbrA-5k6oA:
undetectable
1sbrB-5k6oA:
undetectable		 1sbrA-5k6oA:
12.13
1sbrB-5k6oA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5k6o B-GLUCOSIDASE
(metagenome) 		5 / 12 ILE A 663
HIS A 621
GLY A 668
ASP A 626
GLY A 627
 None
 1.11A 1zz1C-5k6oA:
2.4		 1zz1C-5k6oA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 5k6o B-GLUCOSIDASE
(metagenome) 		4 / 8 GLY A 208
THR A 211
ALA A 212
VAL A  83
 None
 0.69A 2a1hA-5k6oA:
undetectable
2a1hB-5k6oA:
undetectable		 2a1hA-5k6oA:
17.83
2a1hB-5k6oA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 5k6o B-GLUCOSIDASE
(metagenome) 		4 / 8 GLU A  12
PHE A 569
VAL A 793
TYR A 623
 None
 1.07A 2fl5E-5k6oA:
4.5
2fl5F-5k6oA:
3.2		 2fl5E-5k6oA:
12.71
2fl5F-5k6oA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 5k6o B-GLUCOSIDASE
(metagenome) 		5 / 10 ILE A 189
LEU A 178
ASN A 179
VAL A 135
ILE A 200
 None
 1.26A 2nnhB-5k6oA:
undetectable		 2nnhB-5k6oA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_1
(PROTEASE)		 5k6o B-GLUCOSIDASE
(metagenome) 		5 / 9 LEU A 554
ILE A 663
GLY A 668
PRO A 585
ILE A 612
 None
 1.07A 2r5qA-5k6oA:
undetectable		 2r5qA-5k6oA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_1
(PROTEASE)		 5k6o B-GLUCOSIDASE
(metagenome) 		5 / 9 LEU A 554
ILE A 663
GLY A 668
PRO A 585
ILE A 612
 None
 1.07A 2r5qC-5k6oA:
undetectable		 2r5qC-5k6oA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 5k6o B-GLUCOSIDASE
(metagenome) 		4 / 7 PHE A 298
ALA A 336
ALA A 300
PHE A 289
 None
 0.84A 2vcvL-5k6oA:
undetectable		 2vcvL-5k6oA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5k6o B-GLUCOSIDASE
(metagenome) 		4 / 5 LEU A 608
GLN A 317
THR A 552
HIS A 590
 None
 1.31A 2zj0C-5k6oA:
undetectable		 2zj0C-5k6oA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 5k6o B-GLUCOSIDASE
(metagenome) 		5 / 12 TYR A 271
LEU A 197
GLY A 276
ASN A 389
ASP A 605
 None
 1.31A 2zznB-5k6oA:
undetectable		 2zznB-5k6oA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 5k6o B-GLUCOSIDASE
(metagenome) 		3 / 3 MET A  62
GLU A 600
ASN A 635
 None
 0.94A 3a27A-5k6oA:
undetectable		 3a27A-5k6oA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 5k6o B-GLUCOSIDASE
(metagenome) 		4 / 7 GLY A 508
SER A 541
ALA A 543
VAL A 579
 None
 0.81A 3a2qA-5k6oA:
undetectable		 3a2qA-5k6oA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5k6o B-GLUCOSIDASE
(metagenome) 		5 / 12 PHE A 171
LEU A 177
LEU A  36
LEU A  87
TYR A  91
 None
 1.47A 3adsA-5k6oA:
undetectable		 3adsA-5k6oA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5k6o B-GLUCOSIDASE
(metagenome) 		3 / 3 THR A 280
SER A 222
LYS A 224
 None
 1.02A 3aocC-5k6oA:
undetectable		 3aocC-5k6oA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		 5k6o B-GLUCOSIDASE
(metagenome) 		4 / 7 TRP A 710
GLY A 627
ASP A 532
ARG A 538
 GAL  A1000 ( 3.8A)
None
GAL  A1000 (-3.1A)
GAL  A1000 (-4.4A)
 1.12A 3arrA-5k6oA:
undetectable		 3arrA-5k6oA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5k6o B-GLUCOSIDASE
(metagenome) 		4 / 5 LEU A 608
GLN A 317
THR A 552
HIS A 590
 None
 1.32A 3ce6B-5k6oA:
undetectable		 3ce6B-5k6oA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_2
(PROTEASE)		 5k6o B-GLUCOSIDASE
(metagenome) 		5 / 9 LEU A 554
ILE A 663
GLY A 668
PRO A 585
ILE A 612
 None
 1.00A 3el0B-5k6oA:
undetectable		 3el0B-5k6oA:
7.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 5k6o B-GLUCOSIDASE
(metagenome) 		3 / 3 GLU A 386
VAL A 286
CYH A 302
 None
 0.71A 3fbxA-5k6oA:
1.0		 3fbxA-5k6oA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW3_A_ETSA302_1
(CARBONIC ANHYDRASE 4)		 5k6o B-GLUCOSIDASE
(metagenome) 		5 / 12 VAL A  42
ILE A 134
VAL A 132
LEU A 215
THR A 216
 None
 0.97A 3fw3A-5k6oA:
undetectable		 3fw3A-5k6oA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW3_B_ETSB303_1
(CARBONIC ANHYDRASE 4)		 5k6o B-GLUCOSIDASE
(metagenome) 		5 / 12 VAL A  42
ILE A 134
VAL A 132
LEU A 215
THR A 216
 None
 1.00A 3fw3B-5k6oA:
undetectable		 3fw3B-5k6oA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 5k6o B-GLUCOSIDASE
(metagenome) 		5 / 12 GLY A 223
GLY A  24
LYS A 313
VAL A 315
GLN A 317
 None
 1.23A 3fzgA-5k6oA:
undetectable		 3fzgA-5k6oA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 5k6o B-GLUCOSIDASE
(metagenome) 		4 / 7 LEU A 186
GLN A 202
VAL A 176
LEU A 156
 None
 0.89A 3g8iA-5k6oA:
undetectable		 3g8iA-5k6oA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_B_1GNB999_1
(GALECTIN-7)		 5k6o B-GLUCOSIDASE
(metagenome) 		4 / 6 HIS A 631
ASN A 635
ARG A 641
GLU A 143
 GAL  A1000 (-4.3A)
None
GAL  A1000 (-3.4A)
GAL  A1000 (-3.4A)
 1.49A 3galB-5k6oA:
undetectable		 3galB-5k6oA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ITA_D_AICD501_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC)		 5k6o B-GLUCOSIDASE
(metagenome) 		3 / 3 PRO A 585
PHE A 673
ALA A 664
 None
 0.69A 3itaD-5k6oA:
undetectable		 3itaD-5k6oA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_C_BCZC1001_0
(NEURAMINIDASE)		 5k6o B-GLUCOSIDASE
(metagenome) 		5 / 12 LEU A 582
ASP A 532
ARG A 538
GLU A 600
ARG A 597
 None
GAL  A1000 (-3.1A)
GAL  A1000 (-4.4A)
None
GAL  A1000 (-3.1A)
 1.50A 3k39C-5k6oA:
undetectable		 3k39C-5k6oA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_J_BCZJ1001_0
(NEURAMINIDASE)		 5k6o B-GLUCOSIDASE
(metagenome) 		5 / 12 LEU A 582
ASP A 532
ARG A 538
GLU A 600
ARG A 597
 None
GAL  A1000 (-3.1A)
GAL  A1000 (-4.4A)
None
GAL  A1000 (-3.1A)
 1.48A 3k39J-5k6oA:
undetectable		 3k39J-5k6oA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_K_BCZK1001_0
(NEURAMINIDASE)		 5k6o B-GLUCOSIDASE
(metagenome) 		5 / 12 LEU A 582
ASP A 532
ARG A 538
GLU A 600
ARG A 597
 None
GAL  A1000 (-3.1A)
GAL  A1000 (-4.4A)
None
GAL  A1000 (-3.1A)
 1.50A 3k39K-5k6oA:
undetectable		 3k39K-5k6oA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_L_BCZL1001_0
(NEURAMINIDASE)		 5k6o B-GLUCOSIDASE
(metagenome) 		5 / 12 LEU A 582
ASP A 532
ARG A 538
GLU A 600
ARG A 597
 None
GAL  A1000 (-3.1A)
GAL  A1000 (-4.4A)
None
GAL  A1000 (-3.1A)
 1.50A 3k39L-5k6oA:
undetectable		 3k39L-5k6oA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_2
(GENOME POLYPROTEIN)		 5k6o B-GLUCOSIDASE
(metagenome) 		4 / 4 GLN A 317
PHE A 558
TYR A 258
LEU A  27
 None
 1.48A 3keeC-5k6oA:
undetectable		 3keeC-5k6oA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_A_4CHA191_0
(DEHALOPEROXIDASE A)		 5k6o B-GLUCOSIDASE
(metagenome) 		4 / 6 PHE A 357
PHE A 399
THR A 297
VAL A 355
 None
 1.18A 3lb3A-5k6oA:
undetectable		 3lb3A-5k6oA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_B_4CHB192_0
(DEHALOPEROXIDASE A)		 5k6o B-GLUCOSIDASE
(metagenome) 		4 / 6 PHE A 357
PHE A 399
THR A 297
VAL A 355
 None
 1.25A 3lb3B-5k6oA:
undetectable		 3lb3B-5k6oA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5k6o B-GLUCOSIDASE
(metagenome) 		5 / 11 PHE A 599
GLY A 204
GLY A 203
TYR A  52
ASN A 179
 None
 1.43A 3owxA-5k6oA:
3.0
3owxB-5k6oA:
2.9		 3owxA-5k6oA:
13.36
3owxB-5k6oA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 5k6o B-GLUCOSIDASE
(metagenome) 		3 / 3 ASP A 365
GLU A 378
SER A 419
 None
 0.55A 3p2kA-5k6oA:
undetectable		 3p2kA-5k6oA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_I_ACHI323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 5k6o B-GLUCOSIDASE
(metagenome) 		4 / 8 TYR A 236
ASN A 592
ILE A 229
TYR A 154
 None
 0.96A 3rqwI-5k6oA:
undetectable
3rqwJ-5k6oA:
undetectable		 3rqwI-5k6oA:
16.98
3rqwJ-5k6oA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 5k6o B-GLUCOSIDASE
(metagenome) 		5 / 12 THR A  57
GLY A 107
GLY A 103
ASP A 144
PHE A 599
 None
 1.29A 3tkaA-5k6oA:
4.1		 3tkaA-5k6oA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)		 5k6o B-GLUCOSIDASE
(metagenome) 		5 / 10 GLU A 758
SER A 754
ASN A 751
GLU A 765
ARG A 451
 SO4  A1004 ( 4.9A)
SO4  A1004 (-3.5A)
SO4  A1004 (-3.6A)
None
None
 1.37A 3u6tA-5k6oA:
undetectable		 3u6tA-5k6oA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		 5k6o B-GLUCOSIDASE
(metagenome) 		5 / 10 VAL A  42
VAL A 132
LEU A 215
THR A 216
VAL A 175
 None
 0.99A 4e3hA-5k6oA:
undetectable		 4e3hA-5k6oA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 5k6o B-GLUCOSIDASE
(metagenome) 		3 / 3 PHE A 673
ASP A 735
ARG A 697
 None
 0.86A 4eahF-5k6oA:
undetectable		 4eahF-5k6oA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 5k6o B-GLUCOSIDASE
(metagenome) 		3 / 3 PHE A 673
ASP A 735
ARG A 697
 None
 0.86A 4eahG-5k6oA:
undetectable		 4eahG-5k6oA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 5k6o B-GLUCOSIDASE
(metagenome) 		5 / 12 GLY A 586
SER A 646
VAL A 648
TYR A 657
ASN A 636
 None
 1.42A 4ffwA-5k6oA:
undetectable		 4ffwA-5k6oA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_B_CLQB303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5k6o B-GLUCOSIDASE
(metagenome) 		5 / 11 PHE A 599
GLY A 204
GLY A 203
TYR A  52
ASN A 179
 None
 1.43A 4fglA-5k6oA:
3.0
4fglB-5k6oA:
3.1		 4fglA-5k6oA:
13.82
4fglB-5k6oA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K13_A_ETSA304_1
(CARBONIC ANHYDRASE 2)		 5k6o B-GLUCOSIDASE
(metagenome) 		5 / 12 VAL A 199
LEU A 186
LEU A  28
VAL A  26
THR A 226
 None
 0.99A 4k13A-5k6oA:
undetectable		 4k13A-5k6oA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYS_B_VIBB501_1
(THIAMINE
PYRIDINYLASE I)		 5k6o B-GLUCOSIDASE
(metagenome) 		5 / 11 TYR A 154
ASP A 185
ILE A 189
SER A 190
LEU A 197
 None
 1.34A 4kysB-5k6oA:
undetectable		 4kysB-5k6oA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_0
(NEURAMINIDASE)		 5k6o B-GLUCOSIDASE
(metagenome) 		5 / 12 LEU A 582
ASP A 532
ARG A 538
GLU A 600
ARG A 597
 None
GAL  A1000 (-3.1A)
GAL  A1000 (-4.4A)
None
GAL  A1000 (-3.1A)
 1.45A 4mwvA-5k6oA:
undetectable		 4mwvA-5k6oA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVT_B_ACTB200_0
(N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE)		 5k6o B-GLUCOSIDASE
(metagenome) 		3 / 3 ASN A 725
ALA A 727
ARG A 731
 None
 0.47A 5cvtB-5k6oA:
3.9		 5cvtB-5k6oA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)		 5k6o B-GLUCOSIDASE
(metagenome) 		4 / 5 GLN A 113
ILE A  48
ILE A 137
TYR A  53
 None
 0.82A 5dnvA-5k6oA:
undetectable		 5dnvA-5k6oA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5k6o B-GLUCOSIDASE
(metagenome) 		4 / 5 THR A  57
ALA A 141
THR A 140
TYR A  53
 None
 1.31A 5ecmA-5k6oA:
undetectable		 5ecmA-5k6oA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 5k6o B-GLUCOSIDASE
(metagenome) 		5 / 12 GLY A 207
SER A 547
ARG A 798
GLY A  74
HIS A  67
 None
 1.07A 5gwxA-5k6oA:
undetectable		 5gwxA-5k6oA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 5k6o B-GLUCOSIDASE
(metagenome) 		3 / 3 VAL A 180
GLU A 115
GLU A 160
 None
 0.77A 5jsdB-5k6oA:
undetectable
5jsdC-5k6oA:
undetectable		 5jsdB-5k6oA:
21.82
5jsdC-5k6oA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LBT_A_6T0A304_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5k6o B-GLUCOSIDASE
(metagenome) 		5 / 10 GLY A 204
GLY A 203
TYR A  52
ASN A 179
PHE A 599
 None
 1.44A 5lbtA-5k6oA:
2.5
5lbtB-5k6oA:
3.1		 5lbtA-5k6oA:
13.21
5lbtB-5k6oA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 5k6o B-GLUCOSIDASE
(metagenome) 		3 / 3 ASN A 636
TYR A 250
CYH A 644
 None
 1.11A 5lsuB-5k6oA:
undetectable		 5lsuB-5k6oA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M67_C_ACTC504_0
(ADENOSYLHOMOCYSTEINA
SE)		 5k6o B-GLUCOSIDASE
(metagenome) 		4 / 4 ASP A 690
ILE A 695
ARG A 654
ARG A 450
 None
None
None
SO4  A1001 (-3.7A)
 1.37A 5m67C-5k6oA:
1.3		 5m67C-5k6oA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M6G_A_SORA711_0
(BETA-GLUCOSIDASE)		 5k6o B-GLUCOSIDASE
(metagenome) 		6 / 12 ASP A 532
ARG A 597
LYS A 630
HIS A 631
MET A 674
GLU A 143
 GAL  A1000 (-3.1A)
GAL  A1000 (-3.1A)
GAL  A1000 (-3.0A)
GAL  A1000 (-4.3A)
GAL  A1000 ( 3.9A)
GAL  A1000 (-3.4A)
 0.35A 5m6gA-5k6oA:
18.6		 5m6gA-5k6oA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_F_EZLF302_1
(ALPHA-CARBONIC
ANHYDRASE)		 5k6o B-GLUCOSIDASE
(metagenome) 		4 / 8 VAL A 199
VAL A  26
LEU A 225
THR A 226
 None
 0.85A 5tt3F-5k6oA:
undetectable		 5tt3F-5k6oA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_B_SAMB601_0
(NS5
METHYLTRANSFERASE)		 5k6o B-GLUCOSIDASE
(metagenome) 		6 / 12 GLY A 207
GLY A  74
GLY A 210
GLU A  73
VAL A  42
ILE A  44
 None
 1.07A 5wz1B-5k6oA:
undetectable		 5wz1B-5k6oA:
14.98