SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5k7l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5k7l POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 1
(Rattus
norvegicus) 		5 / 12 ALA A 558
LEU A 654
PHE A 664
ILE A 645
LEU A 591
 None
 1.27A 1dreA-5k7lA:
undetectable		 1dreA-5k7lA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E71_M_ASCM995_0
(MYROSINASE MA1)		 5k7l POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 1
(Rattus
norvegicus) 		4 / 7 ILE A  97
PHE A 130
PHE A  49
PHE A  69
 None
 1.08A 1e71M-5k7lA:
undetectable		 1e71M-5k7lA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E72_M_ASCM995_0
(MYROSINASE MA1)		 5k7l POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 1
(Rattus
norvegicus) 		4 / 7 ILE A  97
PHE A 130
PHE A  49
PHE A  69
 None
 1.07A 1e72M-5k7lA:
undetectable		 1e72M-5k7lA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5k7l POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 1
(Rattus
norvegicus) 		5 / 12 ALA A 558
LEU A 654
PHE A 664
ILE A 645
LEU A 591
 None
 1.12A 1rx3A-5k7lA:
undetectable		 1rx3A-5k7lA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5k7l POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 1
(Rattus
norvegicus) 		4 / 6 PHE A 593
VAL A 616
LEU A 670
PHE A 555
 None
 0.86A 1wrlB-5k7lA:
undetectable		 1wrlB-5k7lA:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5k7l POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 1
(Rattus
norvegicus) 		4 / 5 PHE A 593
LEU A 670
PHE A 555
SER A 661
 None
 1.02A 1wrlC-5k7lA:
undetectable		 1wrlC-5k7lA:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5k7l POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 1
(Rattus
norvegicus) 		5 / 12 LEU A 580
ILE A 602
ALA A 632
SER A 630
LEU A 674
 None
 0.92A 2aylB-5k7lA:
undetectable		 2aylB-5k7lA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_A_BEZA1222_0
(PEROXIREDOXIN 6)		 5k7l POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 1
(Rattus
norvegicus) 		4 / 8 THR A 105
PRO A 106
VAL A 107
ALA A 157
 None
 0.93A 2v32A-5k7lA:
undetectable
2v32B-5k7lA:
undetectable		 2v32A-5k7lA:
14.24
2v32B-5k7lA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_B_BEZB1220_0
(PEROXIREDOXIN 6)		 5k7l POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 1
(Rattus
norvegicus) 		4 / 8 THR A 105
PRO A 106
VAL A 107
ALA A 157
 None
 0.93A 2v32A-5k7lA:
undetectable
2v32B-5k7lA:
undetectable		 2v32A-5k7lA:
14.24
2v32B-5k7lA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 5k7l POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 1
(Rattus
norvegicus) 		4 / 8 ILE A 373
GLY A 374
LEU A 392
LEU A 395
 None
 0.78A 2vctB-5k7lA:
2.1		 2vctB-5k7lA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XPW_A_OTCA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5k7l POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 1
(Rattus
norvegicus) 		5 / 12 LEU A 674
PHE A 617
ARG A 635
VAL A 608
ILE A 610
 None
 1.29A 2xpwA-5k7lA:
undetectable		 2xpwA-5k7lA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5k7l POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 1
(Rattus
norvegicus) 		5 / 12 LEU A 580
ILE A 602
ALA A 632
SER A 630
LEU A 674
 None
 0.90A 3n8xA-5k7lA:
undetectable		 3n8xA-5k7lA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5k7l POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 1
(Rattus
norvegicus) 		5 / 12 LEU A 580
ILE A 602
ALA A 632
SER A 630
LEU A 674
 None
 0.85A 3n8xB-5k7lA:
undetectable		 3n8xB-5k7lA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5k7l POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 1
(Rattus
norvegicus) 		5 / 11 LEU A 580
ILE A 602
ALA A 632
SER A 630
LEU A 674
 None
 1.07A 3n8yA-5k7lA:
undetectable		 3n8yA-5k7lA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5k7l POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 1
(Rattus
norvegicus) 		5 / 12 LEU A 580
ILE A 602
ALA A 632
SER A 630
LEU A 674
 None
 0.77A 3n8zB-5k7lA:
undetectable		 3n8zB-5k7lA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5k7l POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 1
(Rattus
norvegicus) 		5 / 12 LEU A 674
PHE A 617
ARG A 635
VAL A 608
ILE A 610
 None
 1.30A 4b3aA-5k7lA:
undetectable		 4b3aA-5k7lA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 5k7l POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 1
(Rattus
norvegicus) 		4 / 8 TYR A  44
ASN A  46
ASP A  47
LEU A  18
 None
 0.75A 4f8hA-5k7lA:
3.3
4f8hB-5k7lA:
3.3		 4f8hA-5k7lA:
16.38
4f8hB-5k7lA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 5k7l POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 1
(Rattus
norvegicus) 		4 / 8 TYR A  44
ASN A  46
ASP A  47
LEU A  18
 None
 0.79A 4f8hB-5k7lA:
3.3
4f8hC-5k7lA:
3.3		 4f8hB-5k7lA:
16.38
4f8hC-5k7lA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 5k7l POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 1
(Rattus
norvegicus) 		4 / 8 TYR A  44
ASN A  46
ASP A  47
LEU A  18
 None
 0.75A 4f8hC-5k7lA:
3.3
4f8hD-5k7lA:
3.3		 4f8hC-5k7lA:
16.38
4f8hD-5k7lA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 5k7l POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 1
(Rattus
norvegicus) 		4 / 8 TYR A  44
ASN A  46
ASP A  47
LEU A  18
 None
 0.76A 4f8hD-5k7lA:
3.3
4f8hE-5k7lA:
3.3		 4f8hD-5k7lA:
16.38
4f8hE-5k7lA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 5k7l POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 1
(Rattus
norvegicus) 		4 / 8 LEU A  18
TYR A  44
ASN A  46
ASP A  47
 None
 0.77A 4f8hA-5k7lA:
3.3
4f8hE-5k7lA:
3.3		 4f8hA-5k7lA:
16.38
4f8hE-5k7lA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)		 5k7l POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 1
(Rattus
norvegicus) 		3 / 3 TRP A 370
ILE A 456
SER A 433
 None
 0.94A 5gqbA-5k7lA:
undetectable		 5gqbA-5k7lA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5k7l POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 1
(Rattus
norvegicus) 		4 / 5 LEU A 670
PHE A 617
LEU A 668
PHE A 664
 None
 1.18A 5iy5P-5k7lA:
2.3
5iy5W-5k7lA:
undetectable		 5iy5P-5k7lA:
14.72
5iy5W-5k7lA:
5.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5k7l POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 1
(Rattus
norvegicus) 		4 / 5 LEU A 670
PHE A 617
LEU A 668
PHE A 664
 None
 1.18A 5x1fC-5k7lA:
4.4
5x1fJ-5k7lA:
undetectable		 5x1fC-5k7lA:
14.96
5x1fJ-5k7lA:
6.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 5k7l POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 1
(Rattus
norvegicus) 		4 / 5 LEU A 670
PHE A 617
LEU A 668
PHE A 664
 None
 1.23A 5xdxC-5k7lA:
2.3
5xdxJ-5k7lA:
undetectable		 5xdxC-5k7lA:
14.86
5xdxJ-5k7lA:
6.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 5k7l POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 1
(Rattus
norvegicus) 		4 / 5 LEU A 670
PHE A 617
LEU A 668
PHE A 664
 None
 1.21A 5xdxP-5k7lA:
2.3
5xdxW-5k7lA:
undetectable		 5xdxP-5k7lA:
14.86
5xdxW-5k7lA:
6.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 5k7l POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 1
(Rattus
norvegicus) 		6 / 12 LEU A 591
HIS A 552
LEU A 668
LEU A 670
GLY A 612
LEU A 611
 None
 1.49A 6b0cD-5k7lA:
undetectable		 6b0cD-5k7lA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUO_D_08HD501_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)		 5k7l POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 1
(Rattus
norvegicus) 		4 / 8 TYR A 198
PHE A  17
VAL A  43
TYR A  44
 None
 1.17A 6huoC-5k7lA:
2.7
6huoD-5k7lA:
2.9		 6huoC-5k7lA:
8.73
6huoD-5k7lA:
6.87