SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5k7m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 5k7m N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14
(Homo
sapiens) 		3 / 3 ASP B 350
THR B 352
GLU B 192
 None
 0.81A 1pj7A-5k7mB:
undetectable		 1pj7A-5k7mB:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B304_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5k7m N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14
(Homo
sapiens) 		4 / 5 ASN B 368
THR B 363
SER B 351
ARG B 349
 None
 1.49A 3hlwB-5k7mB:
undetectable		 3hlwB-5k7mB:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 5k7m N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14
(Homo
sapiens) 		4 / 4 CYH B 288
PHE B 232
ILE B 221
GLY B 291
 None
 1.40A 5hesB-5k7mB:
undetectable		 5hesB-5k7mB:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_0
(METTL3)		 5k7m N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14
(Homo
sapiens) 		6 / 12 ASP B 173
ILE B 174
PRO B 194
LYS B 326
PHE B 347
GLY B 361
 None
 0.68A 5il1A-5k7mB:
21.5		 5il1A-5k7mB:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 5k7m N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14
(Homo
sapiens) 		6 / 12 ASP B 173
ILE B 174
PRO B 194
LYS B 326
PHE B 347
GLY B 361
 None
 0.71A 5k7uA-5k7mB:
21.0		 5k7uA-5k7mB:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 5k7m N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14
(Homo
sapiens) 		6 / 12 ILE B 174
PRO B 194
LYS B 326
PHE B 347
GLY B 348
GLY B 361
 None
 0.71A 5l6eA-5k7mB:
20.5		 5l6eA-5k7mB:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 5k7m N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14
(Homo
sapiens) 		4 / 6 ARG B 245
LEU B 248
ARG B 254
ARG B 255
 None
 0.31A 5l6eA-5k7mB:
20.5
5l6eB-5k7mB:
33.0		 5l6eA-5k7mB:
25.76
5l6eB-5k7mB:
98.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 5k7m N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14
(Homo
sapiens) 		4 / 8 ILE B 189
ALA B 225
ILE B 224
TYR B 253
 None
 0.72A 5mvmA-5k7mB:
undetectable
5mvmB-5k7mB:
undetectable		 5mvmA-5k7mB:
13.62
5mvmB-5k7mB:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 5k7m N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14
(Homo
sapiens) 		4 / 6 ARG B 354
GLY B 356
PRO B 355
GLU B 335
 None
 0.82A 5ny7A-5k7mB:
undetectable		 5ny7A-5k7mB:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5k7m N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14
(Homo
sapiens) 		3 / 3 ARG B 245
LEU B 289
PHE B 232
 None
 0.74A 6nknP-5k7mB:
undetectable		 6nknP-5k7mB:
19.37