SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5k7v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 5k7v DESIGNED PROTEIN
HR00C3
(synthetic
construct) 		4 / 5 ILE A  74
LEU A  77
ASP A  10
ALA A  70
 None
 1.02A 2opxA-5k7vA:
undetectable		 2opxA-5k7vA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 5k7v DESIGNED PROTEIN
HR00C3
(synthetic
construct) 		5 / 11 ALA A 135
ILE A 113
ILE A  71
ALA A 120
ALA A 117
 None
 1.19A 2qhfA-5k7vA:
undetectable		 2qhfA-5k7vA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 5k7v DESIGNED PROTEIN
HR00C3
(synthetic
construct) 		5 / 11 ALA A 177
ILE A 133
ILE A 113
ALA A 140
ALA A 137
 None
 1.19A 2qhfA-5k7vA:
undetectable		 2qhfA-5k7vA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 5k7v DESIGNED PROTEIN
HR00C3
(synthetic
construct) 		5 / 12 LEU A 119
ILE A  74
ALA A  73
ALA A   6
ALA A  58
 None
 1.01A 4enhA-5k7vA:
undetectable		 4enhA-5k7vA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 5k7v DESIGNED PROTEIN
HR00C3
(synthetic
construct) 		5 / 12 LEU A 212
ILE A 167
ALA A 166
ALA A  99
ALA A 151
 None
 0.98A 4enhA-5k7vA:
undetectable		 4enhA-5k7vA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5k7v DESIGNED PROTEIN
HR00C3
(synthetic
construct) 		4 / 5 SER A 183
ALA A 182
MET A 129
LEU A 180
 None
 1.08A 5dzkb-5k7vA:
undetectable
5dzkp-5k7vA:
undetectable		 5dzkb-5k7vA:
23.15
5dzkp-5k7vA:
1.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5k7v DESIGNED PROTEIN
HR00C3
(synthetic
construct) 		4 / 6 SER A 183
ALA A 182
MET A 129
LEU A 180
 None
 1.04A 5dzkB-5k7vA:
undetectable
5dzkP-5k7vA:
undetectable		 5dzkB-5k7vA:
23.15
5dzkP-5k7vA:
1.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5k7v DESIGNED PROTEIN
HR00C3
(synthetic
construct) 		4 / 5 SER A 183
ALA A 182
MET A 129
LEU A 180
 None
 1.09A 5dzkc-5k7vA:
2.5
5dzkq-5k7vA:
undetectable		 5dzkc-5k7vA:
23.15
5dzkq-5k7vA:
1.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5k7v DESIGNED PROTEIN
HR00C3
(synthetic
construct) 		4 / 5 SER A 183
ALA A 182
MET A 129
LEU A 180
 None
 1.05A 5dzkf-5k7vA:
undetectable
5dzkt-5k7vA:
undetectable		 5dzkf-5k7vA:
23.15
5dzkt-5k7vA:
1.17