SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5k8b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 5k8b 8-AMINO-3,8-DIDEOXY-
ALPHA-D-MANNO-OCTULO
SONATE TRANSAMINASE
(Shewanella
oneidensis) 		4 / 6 LEU A 112
ILE A 356
TYR A 326
VAL A 120
 None
 0.99A 1db1A-5k8bA:
undetectable		 1db1A-5k8bA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_2
(HIV-1 PROTEASE)		 5k8b 8-AMINO-3,8-DIDEOXY-
ALPHA-D-MANNO-OCTULO
SONATE TRANSAMINASE
(Shewanella
oneidensis) 		5 / 11 LEU A 375
GLY A 289
ALA A 288
GLY A 163
ILE A 162
 None
 0.99A 1hxwB-5k8bA:
undetectable		 1hxwB-5k8bA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQJ_A_TRPA650_0
(TRYPTOPHAN
HALOGENASE, PRNA)		 5k8b 8-AMINO-3,8-DIDEOXY-
ALPHA-D-MANNO-OCTULO
SONATE TRANSAMINASE
(Shewanella
oneidensis) 		5 / 11 ILE A  81
ILE A 146
HIS A 150
GLU A 118
GLU A  79
 None
 1.44A 2aqjA-5k8bA:
undetectable		 2aqjA-5k8bA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 5k8b 8-AMINO-3,8-DIDEOXY-
ALPHA-D-MANNO-OCTULO
SONATE TRANSAMINASE
(Shewanella
oneidensis) 		5 / 10 GLY A 193
GLY A  61
THR A  62
ALA A  63
ALA A  64
 None
PDG  A 501 (-3.4A)
PDG  A 501 (-3.7A)
None
None
 0.83A 2ej3B-5k8bA:
undetectable		 2ej3B-5k8bA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)		 5k8b 8-AMINO-3,8-DIDEOXY-
ALPHA-D-MANNO-OCTULO
SONATE TRANSAMINASE
(Shewanella
oneidensis) 		5 / 11 ILE A 197
GLY A 175
GLU A 156
THR A 198
GLY A 172
 None
 1.42A 2fn1B-5k8bA:
undetectable		 2fn1B-5k8bA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5k8b 8-AMINO-3,8-DIDEOXY-
ALPHA-D-MANNO-OCTULO
SONATE TRANSAMINASE
(Shewanella
oneidensis) 		3 / 3 ASN A 311
ILE A 386
MET A 269
 None
 0.75A 2h42C-5k8bA:
undetectable		 2h42C-5k8bA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)		 5k8b 8-AMINO-3,8-DIDEOXY-
ALPHA-D-MANNO-OCTULO
SONATE TRANSAMINASE
(Shewanella
oneidensis) 		6 / 12 LEU A 243
GLY A 244
GLN A 247
ALA A 195
LEU A  58
MET A  42
 None
 1.22A 2oz7A-5k8bA:
undetectable		 2oz7A-5k8bA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)		 5k8b 8-AMINO-3,8-DIDEOXY-
ALPHA-D-MANNO-OCTULO
SONATE TRANSAMINASE
(Shewanella
oneidensis) 		4 / 8 ASN A 261
LYS A 262
PRO A   2
PHE A   4
 None
CL  A 503 (-3.0A)
None
None
 1.22A 3bjwD-5k8bA:
undetectable		 3bjwD-5k8bA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 5k8b 8-AMINO-3,8-DIDEOXY-
ALPHA-D-MANNO-OCTULO
SONATE TRANSAMINASE
(Shewanella
oneidensis) 		4 / 6 ASP A 221
HIS A 217
ASP A 212
HIS A 215
 None
 0.83A 3c0zC-5k8bA:
undetectable		 3c0zC-5k8bA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)		 5k8b 8-AMINO-3,8-DIDEOXY-
ALPHA-D-MANNO-OCTULO
SONATE TRANSAMINASE
(Shewanella
oneidensis) 		4 / 4 PRO A   2
THR A 187
GLY A  61
THR A  62
 None
None
PDG  A 501 (-3.4A)
PDG  A 501 (-3.7A)
 1.12A 3ib1A-5k8bA:
0.7		 3ib1A-5k8bA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5k8b 8-AMINO-3,8-DIDEOXY-
ALPHA-D-MANNO-OCTULO
SONATE TRANSAMINASE
(Shewanella
oneidensis) 		5 / 12 GLY A   8
ALA A 246
ALA A 242
ALA A 241
SER A 237
 None
 1.10A 3sudA-5k8bA:
undetectable		 3sudA-5k8bA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_B_ADNB301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 5k8b 8-AMINO-3,8-DIDEOXY-
ALPHA-D-MANNO-OCTULO
SONATE TRANSAMINASE
(Shewanella
oneidensis) 		5 / 10 ALA A 127
LEU A 112
LEU A 154
ASN A 151
ILE A 143
 None
 1.16A 3wdmB-5k8bA:
undetectable		 3wdmB-5k8bA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5k8b 8-AMINO-3,8-DIDEOXY-
ALPHA-D-MANNO-OCTULO
SONATE TRANSAMINASE
(Shewanella
oneidensis) 		5 / 10 GLY A 231
ASP A 212
GLY A 214
HIS A  56
HIS A 217
 None
 1.09A 4c5nB-5k8bA:
3.4		 4c5nB-5k8bA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5k8b 8-AMINO-3,8-DIDEOXY-
ALPHA-D-MANNO-OCTULO
SONATE TRANSAMINASE
(Shewanella
oneidensis) 		5 / 12 GLN A 258
GLY A 164
ALA A 170
GLU A 156
LEU A 248
 None
 1.31A 4retC-5k8bA:
undetectable		 4retC-5k8bA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 5k8b 8-AMINO-3,8-DIDEOXY-
ALPHA-D-MANNO-OCTULO
SONATE TRANSAMINASE
(Shewanella
oneidensis) 		4 / 5 GLY A 172
THR A 173
GLY A 164
GLU A 156
 None
 0.84A 4v20A-5k8bA:
undetectable		 4v20A-5k8bA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_B_ACTB1321_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT)		 5k8b 8-AMINO-3,8-DIDEOXY-
ALPHA-D-MANNO-OCTULO
SONATE TRANSAMINASE
(Shewanella
oneidensis) 		3 / 3 THR A 378
ASP A 379
ALA A 380
 None
 0.07A 5g5gB-5k8bA:
undetectable		 5g5gB-5k8bA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 5k8b 8-AMINO-3,8-DIDEOXY-
ALPHA-D-MANNO-OCTULO
SONATE TRANSAMINASE
(Shewanella
oneidensis) 		3 / 3 MET A 140
HIS A 132
GLY A 175
 None
 0.73A 5gwzB-5k8bA:
undetectable		 5gwzB-5k8bA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 5k8b 8-AMINO-3,8-DIDEOXY-
ALPHA-D-MANNO-OCTULO
SONATE TRANSAMINASE
(Shewanella
oneidensis) 		5 / 12 MET A  42
ALA A  55
LEU A 248
ILE A 188
CYH A 159
 None
None
None
None
PDG  A 501 (-3.7A)
 1.29A 5vlmG-5k8bA:
undetectable		 5vlmG-5k8bA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 5k8b 8-AMINO-3,8-DIDEOXY-
ALPHA-D-MANNO-OCTULO
SONATE TRANSAMINASE
(Shewanella
oneidensis) 		5 / 12 ILE A 162
PHE A 182
GLY A  61
ALA A  64
ILE A 197
 None
None
PDG  A 501 (-3.4A)
None
None
 1.02A 6dwnD-5k8bA:
undetectable		 6dwnD-5k8bA:
12.54