SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5k8c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 5k8c 3-DEOXY-ALPHA-D-MANN
O-OCTULOSONATE
8-OXIDASE
(Shewanella
oneidensis) 		4 / 8 ASP A 104
GLY A 273
THR A 191
GLY A 145
 NAD  A 401 (-2.8A)
NAD  A 401 ( 4.8A)
NAD  A 401 (-2.9A)
None
 0.66A 1jr1B-5k8cA:
undetectable		 1jr1B-5k8cA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5k8c 3-DEOXY-ALPHA-D-MANN
O-OCTULOSONATE
8-OXIDASE
(Shewanella
oneidensis) 		5 / 11 GLY A 145
HIS A 272
SER A 248
GLY A 192
ILE A 274
 None
ZN  A 407 (-3.3A)
None
None
CL  A 404 (-4.5A)
 0.99A 1jzsA-5k8cA:
undetectable		 1jzsA-5k8cA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 5k8c 3-DEOXY-ALPHA-D-MANN
O-OCTULOSONATE
8-OXIDASE
(Shewanella
oneidensis) 		4 / 6 HIS A  45
LEU A  22
ILE A 138
SER A  18
 NAD  A 401 (-4.6A)
None
None
None
 1.18A 1sbrA-5k8cA:
undetectable
1sbrB-5k8cA:
undetectable		 1sbrA-5k8cA:
20.00
1sbrB-5k8cA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)		 5k8c 3-DEOXY-ALPHA-D-MANN
O-OCTULOSONATE
8-OXIDASE
(Shewanella
oneidensis) 		4 / 7 ASP A 104
GLY A 246
ILE A 249
THR A 168
 NAD  A 401 (-2.8A)
None
None
None
 0.81A 1t7iB-5k8cA:
undetectable		 1t7iB-5k8cA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 5k8c 3-DEOXY-ALPHA-D-MANN
O-OCTULOSONATE
8-OXIDASE
(Shewanella
oneidensis) 		4 / 7 ASP A 104
GLY A 246
ILE A 249
THR A 168
 NAD  A 401 (-2.8A)
None
None
None
 0.77A 1t7jB-5k8cA:
undetectable		 1t7jB-5k8cA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_3
(PHOSPHOLIPASE A2)		 5k8c 3-DEOXY-ALPHA-D-MANN
O-OCTULOSONATE
8-OXIDASE
(Shewanella
oneidensis) 		5 / 12 VAL A  41
LEU A  40
GLY A  96
ILE A 136
LYS A  31
 None
 1.24A 3bjwF-5k8cA:
undetectable		 3bjwF-5k8cA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_2
(PROTEASE)		 5k8c 3-DEOXY-ALPHA-D-MANN
O-OCTULOSONATE
8-OXIDASE
(Shewanella
oneidensis) 		5 / 10 ASP A 104
GLY A 100
GLY A 137
ILE A 173
THR A 168
 NAD  A 401 (-2.8A)
NAD  A 401 (-3.3A)
None
None
None
 1.06A 3el9B-5k8cA:
undetectable		 3el9B-5k8cA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_2
(PROTEASE)		 5k8c 3-DEOXY-ALPHA-D-MANN
O-OCTULOSONATE
8-OXIDASE
(Shewanella
oneidensis) 		5 / 10 ILE A 138
GLY A  96
LEU A  40
VAL A  56
ILE A  54
 None
 0.85A 3em4V-5k8cA:
undetectable		 3em4V-5k8cA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_2
(PROTEASE)		 5k8c 3-DEOXY-ALPHA-D-MANN
O-OCTULOSONATE
8-OXIDASE
(Shewanella
oneidensis) 		5 / 9 ASP A 104
GLY A 100
GLY A 137
ILE A 173
THR A 168
 NAD  A 401 (-2.8A)
NAD  A 401 (-3.3A)
None
None
None
 1.03A 3gguB-5k8cA:
undetectable		 3gguB-5k8cA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		 5k8c 3-DEOXY-ALPHA-D-MANN
O-OCTULOSONATE
8-OXIDASE
(Shewanella
oneidensis) 		5 / 11 GLU A 284
LEU A 352
ARG A 355
GLY A 255
HIS A 258
 None
None
None
None
ZN  A 407 (-3.5A)
 1.39A 3hm1B-5k8cA:
undetectable		 3hm1B-5k8cA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 5k8c 3-DEOXY-ALPHA-D-MANN
O-OCTULOSONATE
8-OXIDASE
(Shewanella
oneidensis) 		5 / 10 VAL A  95
LEU A 179
GLY A  96
VAL A  41
GLY A  98
 None
 1.21A 3ls4H-5k8cA:
undetectable		 3ls4H-5k8cA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 5k8c 3-DEOXY-ALPHA-D-MANN
O-OCTULOSONATE
8-OXIDASE
(Shewanella
oneidensis) 		5 / 12 ILE A 141
SER A 142
GLY A 143
THR A 144
GLU A 147
 NAD  A 401 (-3.8A)
None
None
NAD  A 401 (-3.9A)
None
 1.12A 3r75A-5k8cA:
undetectable		 3r75A-5k8cA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R76_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 5k8c 3-DEOXY-ALPHA-D-MANN
O-OCTULOSONATE
8-OXIDASE
(Shewanella
oneidensis) 		5 / 11 ILE A 141
SER A 142
GLY A 143
THR A 144
GLU A 147
 NAD  A 401 (-3.8A)
None
None
NAD  A 401 (-3.9A)
None
 1.19A 3r76B-5k8cA:
undetectable		 3r76B-5k8cA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5k8c 3-DEOXY-ALPHA-D-MANN
O-OCTULOSONATE
8-OXIDASE
(Shewanella
oneidensis) 		5 / 12 PHE A 170
THR A 140
LEU A  40
VAL A 109
VAL A  65
 None
NAD  A 401 (-4.0A)
None
None
CL  A 406 ( 4.1A)
 1.39A 3u9fP-5k8cA:
undetectable
3u9fS-5k8cA:
undetectable		 3u9fP-5k8cA:
22.13
3u9fS-5k8cA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 5k8c 3-DEOXY-ALPHA-D-MANN
O-OCTULOSONATE
8-OXIDASE
(Shewanella
oneidensis) 		5 / 11 ALA A 216
LEU A 203
ARG A 224
GLY A 255
HIS A 258
 None
None
None
None
ZN  A 407 (-3.5A)
 1.23A 3uudA-5k8cA:
undetectable		 3uudA-5k8cA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 5k8c 3-DEOXY-ALPHA-D-MANN
O-OCTULOSONATE
8-OXIDASE
(Shewanella
oneidensis) 		5 / 12 ALA A 146
MET A 103
ALA A 108
GLY A 162
LEU A 163
 NAD  A 401 (-3.5A)
None
None
None
None
 1.02A 4oaeA-5k8cA:
undetectable		 4oaeA-5k8cA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 5k8c 3-DEOXY-ALPHA-D-MANN
O-OCTULOSONATE
8-OXIDASE
(Shewanella
oneidensis) 		3 / 3 PRO A 330
LEU A 331
HIS A 198
 None
 0.60A 4pevA-5k8cA:
5.3		 4pevA-5k8cA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 5k8c 3-DEOXY-ALPHA-D-MANN
O-OCTULOSONATE
8-OXIDASE
(Shewanella
oneidensis) 		5 / 12 THR A 102
GLY A 145
SER A 149
ALA A 148
LYS A 107
 None
None
NAD  A 401 (-2.6A)
None
NAD  A 401 ( 3.7A)
 1.23A 4ypmA-5k8cA:
undetectable		 4ypmA-5k8cA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)		 5k8c 3-DEOXY-ALPHA-D-MANN
O-OCTULOSONATE
8-OXIDASE
(Shewanella
oneidensis) 		5 / 11 ALA A 216
LEU A 203
ARG A 224
GLY A 255
HIS A 258
 None
None
None
None
ZN  A 407 (-3.5A)
 1.22A 5dxbB-5k8cA:
undetectable		 5dxbB-5k8cA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)		 5k8c 3-DEOXY-ALPHA-D-MANN
O-OCTULOSONATE
8-OXIDASE
(Shewanella
oneidensis) 		5 / 11 ALA A 216
LEU A 203
ARG A 224
GLY A 255
HIS A 258
 None
None
None
None
ZN  A 407 (-3.5A)
 1.26A 5dxgB-5k8cA:
undetectable		 5dxgB-5k8cA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 5k8c 3-DEOXY-ALPHA-D-MANN
O-OCTULOSONATE
8-OXIDASE
(Shewanella
oneidensis) 		5 / 9 ALA A 216
LEU A 203
ARG A 224
GLY A 255
HIS A 258
 None
None
None
None
ZN  A 407 (-3.5A)
 1.27A 5wgqA-5k8cA:
undetectable		 5wgqA-5k8cA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 5k8c 3-DEOXY-ALPHA-D-MANN
O-OCTULOSONATE
8-OXIDASE
(Shewanella
oneidensis) 		5 / 12 LEU A  97
ILE A 138
GLY A 137
ILE A  54
VAL A  56
 None
 1.01A 6emuC-5k8cA:
undetectable		 6emuC-5k8cA:
19.83