SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5k8d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 5k8d COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 7 TYR A 105
HIS A  99
THR A 118
TYR A 114
 None
None
CA  A 805 (-4.3A)
None
 1.40A 1afsA-5k8dA:
undetectable		 1afsA-5k8dA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5k8d COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 5 GLU A 187
THR A 191
HIS A 193
HIS A 256
 None
 1.40A 1d4fA-5k8dA:
undetectable		 1d4fA-5k8dA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5k8d COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 5 GLU A 187
THR A 191
HIS A 193
HIS A 256
 None
 1.27A 1d4fD-5k8dA:
undetectable		 1d4fD-5k8dA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens) 		5 / 12 ILE B1882
PHE B1883
GLY B1948
MET B2010
LEU B1758
 None
None
None
CU  B2610 ( 3.9A)
None
 1.28A 1fm6X-5k8dB:
undetectable		 1fm6X-5k8dB:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5k8d COAGULATION FACTOR
VIII
COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens;
Homo
sapiens) 		5 / 9 SER B1788
GLY B1981
ALA B1836
THR A 667
THR A 669
 None
 1.47A 1gtnG-5k8dB:
undetectable
1gtnH-5k8dB:
1.5		 1gtnG-5k8dB:
5.92
1gtnH-5k8dB:
5.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5k8d COAGULATION FACTOR
VIII
COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens;
Homo
sapiens) 		5 / 9 GLY B1981
ALA B1836
THR A 667
THR A 669
SER B1788
 None
 1.47A 1gtnS-5k8dB:
1.7
1gtnT-5k8dB:
undetectable		 1gtnS-5k8dB:
5.92
1gtnT-5k8dB:
5.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens) 		4 / 7 VAL B1982
LEU B1978
SER B1955
LEU B1975
 None
 0.88A 1j8uA-5k8dB:
undetectable		 1j8uA-5k8dB:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA501_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens) 		4 / 4 HIS B1954
CYH B2000
HIS B2005
MET B2010
 CU  B2610 (-3.0A)
CU  B2610 (-1.9A)
CU  B2610 (-3.6A)
CU  B2610 ( 3.9A)
 0.86A 1oe1A-5k8dB:
20.7		 1oe1A-5k8dB:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA501_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens) 		4 / 5 HIS B1954
CYH B2000
HIS B2005
MET B2010
 CU  B2610 (-3.0A)
CU  B2610 (-1.9A)
CU  B2610 (-3.6A)
CU  B2610 ( 3.9A)
 0.85A 1oe2A-5k8dB:
20.7		 1oe2A-5k8dB:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA501_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens) 		4 / 4 HIS B1954
CYH B2000
HIS B2005
MET B2010
 CU  B2610 (-3.0A)
CU  B2610 (-1.9A)
CU  B2610 (-3.6A)
CU  B2610 ( 3.9A)
 0.84A 1oe3A-5k8dB:
20.8		 1oe3A-5k8dB:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 5k8d COAGULATION FACTOR
VIII
(Homo
sapiens) 		3 / 3 LEU A 491
HIS A 497
LYS A 496
 None
 1.05A 1y7iA-5k8dA:
undetectable		 1y7iA-5k8dA:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5k8d COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 5 ILE A 173
ILE A 269
ILE A 291
LEU A 242
 None
 0.94A 1zgyA-5k8dA:
undetectable		 1zgyA-5k8dA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5k8d COAGULATION FACTOR
VIII
(Homo
sapiens) 		5 / 12 LEU A 294
LEU A 286
GLU A 676
SER A 268
ASP A 666
 None
 1.06A 2bm9A-5k8dA:
undetectable		 2bm9A-5k8dA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5k8d COAGULATION FACTOR
VIII
(Homo
sapiens) 		5 / 12 LEU A 294
LEU A 286
GLU A 676
SER A 268
ASP A 666
 None
 1.12A 2br4F-5k8dA:
undetectable		 2br4F-5k8dA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 5k8d COAGULATION FACTOR
VIII
COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens) 		5 / 12 SER A 109
LEU A 164
LEU B2001
HIS B1957
ILE A 173
 None
 1.07A 2bxcA-5k8dA:
undetectable		 2bxcA-5k8dA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens) 		4 / 6 ASP B1831
PHE B1830
THR B1964
GLU B1970
 None
 1.29A 2dttB-5k8dB:
undetectable
2dttC-5k8dB:
undetectable		 2dttB-5k8dB:
11.24
2dttC-5k8dB:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_G_BEZG2352_0
(D-AMINO-ACID OXIDASE)		 5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens) 		4 / 5 TYR B2115
TYR B2105
ILE B2145
GLY B2117
 None
 0.89A 2du8G-5k8dB:
undetectable		 2du8G-5k8dB:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQD_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 5k8d COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 4 HIS A 267
CYH A 310
HIS A 232
MET A 320
 CU  A 808 (-2.5A)
CU  A 808 (-2.2A)
CU  A 808 ( 4.6A)
CU  A 808 ( 4.8A)
 1.15A 2fqdA-5k8dA:
19.4		 2fqdA-5k8dA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQD_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 5k8d COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 4 HIS A 267
CYH A 310
HIS A 315
MET A 320
 CU  A 808 (-2.5A)
CU  A 808 (-2.2A)
CU  A 808 (-2.7A)
CU  A 808 ( 4.8A)
 1.23A 2fqdA-5k8dA:
19.4		 2fqdA-5k8dA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQD_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens) 		4 / 4 HIS B1954
CYH B2000
HIS B2005
MET B2010
 CU  B2610 (-3.0A)
CU  B2610 (-1.9A)
CU  B2610 (-3.6A)
CU  B2610 ( 3.9A)
 0.70A 2fqdA-5k8dB:
17.9		 2fqdA-5k8dB:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQE_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 5k8d COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 4 HIS A 267
CYH A 310
HIS A 232
MET A 320
 CU  A 808 (-2.5A)
CU  A 808 (-2.2A)
CU  A 808 ( 4.6A)
CU  A 808 ( 4.8A)
 1.17A 2fqeA-5k8dA:
19.5		 2fqeA-5k8dA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQE_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 5k8d COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 4 HIS A 267
CYH A 310
HIS A 315
MET A 320
 CU  A 808 (-2.5A)
CU  A 808 (-2.2A)
CU  A 808 (-2.7A)
CU  A 808 ( 4.8A)
 1.17A 2fqeA-5k8dA:
19.5		 2fqeA-5k8dA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQE_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens) 		4 / 4 HIS B1954
CYH B2000
HIS B2005
MET B2010
 CU  B2610 (-3.0A)
CU  B2610 (-1.9A)
CU  B2610 (-3.6A)
CU  B2610 ( 3.9A)
 0.68A 2fqeA-5k8dB:
18.0		 2fqeA-5k8dB:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQF_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 5k8d COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 4 HIS A 267
CYH A 310
HIS A 232
MET A 320
 CU  A 808 (-2.5A)
CU  A 808 (-2.2A)
CU  A 808 ( 4.6A)
CU  A 808 ( 4.8A)
 1.19A 2fqfA-5k8dA:
19.5		 2fqfA-5k8dA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQF_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens) 		4 / 4 HIS B1954
CYH B2000
HIS B2005
MET B2010
 CU  B2610 (-3.0A)
CU  B2610 (-1.9A)
CU  B2610 (-3.6A)
CU  B2610 ( 3.9A)
 0.67A 2fqfA-5k8dB:
18.0		 2fqfA-5k8dB:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQG_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 5k8d COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 4 HIS A 267
CYH A 310
HIS A 232
MET A 320
 CU  A 808 (-2.5A)
CU  A 808 (-2.2A)
CU  A 808 ( 4.6A)
CU  A 808 ( 4.8A)
 1.18A 2fqgA-5k8dA:
16.4		 2fqgA-5k8dA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQG_A_CUA601_0
(BLUE COPPER OXIDASE
CUEO)		 5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens) 		4 / 4 HIS B1954
CYH B2000
HIS B2005
MET B2010
 CU  B2610 (-3.0A)
CU  B2610 (-1.9A)
CU  B2610 (-3.6A)
CU  B2610 ( 3.9A)
 0.70A 2fqgA-5k8dB:
18.0		 2fqgA-5k8dB:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 5k8d COAGULATION FACTOR
VIII
(Homo
sapiens) 		5 / 12 ALA A 200
GLY A 174
GLY A 171
ALA A 175
LEU A 177
 None
 1.05A 2plwA-5k8dA:
undetectable		 2plwA-5k8dA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1337_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens) 		4 / 4 HIS B1954
CYH B2000
HIS B2005
MET B2010
 CU  B2610 (-3.0A)
CU  B2610 (-1.9A)
CU  B2610 (-3.6A)
CU  B2610 ( 3.9A)
 0.81A 2xxgA-5k8dB:
undetectable		 2xxgA-5k8dB:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens) 		4 / 5 HIS B1954
CYH B2000
HIS B2005
MET B2010
 CU  B2610 (-3.0A)
CU  B2610 (-1.9A)
CU  B2610 (-3.6A)
CU  B2610 ( 3.9A)
 0.86A 2xxgC-5k8dB:
undetectable		 2xxgC-5k8dB:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens) 		3 / 3 TYR B1762
GLU B1875
THR B1985
 None
 0.79A 2y7hB-5k8dB:
undetectable		 2y7hB-5k8dB:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens) 		5 / 12 ILE B2190
ILE B2185
VAL B2243
VAL B2240
PRO B2177
 None
 0.93A 2ygpA-5k8dB:
2.7		 2ygpA-5k8dB:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 5k8d COAGULATION FACTOR
VIII
(Homo
sapiens) 		5 / 12 LEU A 242
PHE A 309
GLY A 319
ILE A 312
PHE A 270
 None
None
None
CU  A 808 ( 4.9A)
None
 1.10A 2zzmA-5k8dA:
undetectable		 2zzmA-5k8dA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 5k8d COAGULATION FACTOR
VIII
(Homo
sapiens) 		5 / 12 LEU A 242
PHE A 309
GLY A 319
ILE A 312
PHE A 270
 None
None
None
CU  A 808 ( 4.9A)
None
 1.12A 2zznA-5k8dA:
undetectable		 2zznA-5k8dA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)		 5k8d COAGULATION FACTOR
VIII
COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens;
Homo
sapiens) 		3 / 3 MET A 702
GLU B1844
ASP B1884
 None
 0.91A 3a25A-5k8dA:
undetectable		 3a25A-5k8dA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 5k8d COAGULATION FACTOR
VIII
COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens;
Homo
sapiens) 		4 / 6 GLY A 655
SER A 710
GLU B1793
ILE B1790
 None
 0.98A 3a7eA-5k8dA:
undetectable		 3a7eA-5k8dA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR4_X_PNTX101_0
(PROTEIN S100-B)		 5k8d COAGULATION FACTOR
VIII
(Homo
sapiens) 		3 / 3 CYH A 310
HIS A 311
PHE A 270
 CU  A 808 (-2.2A)
None
None
 0.93A 3cr4X-5k8dA:
undetectable		 3cr4X-5k8dA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3007_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens) 		5 / 9 ALA B2089
LEU B2096
ALA B2061
SER B2063
ARG B2159
 None
 1.07A 3kp6B-5k8dB:
undetectable		 3kp6B-5k8dB:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens) 		5 / 10 ILE B1771
TRP B1835
VAL B1773
ILE B1790
SER B1791
 None
 1.37A 3kpbD-5k8dB:
undetectable		 3kpbD-5k8dB:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_A_DSFA319_1
(GLR4197 PROTEIN)		 5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens) 		5 / 9 TYR B1837
ILE B1771
VAL B1773
TYR B1786
ILE B1790
 None
 1.42A 3p4wA-5k8dB:
undetectable		 3p4wA-5k8dB:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA601_0
(LACCASE-1)		 5k8d COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 5 HIS A 267
CYH A 310
ILE A 312
HIS A 315
 CU  A 808 (-2.5A)
CU  A 808 (-2.2A)
CU  A 808 ( 4.9A)
CU  A 808 (-2.7A)
 0.62A 3qpkA-5k8dA:
8.0		 3qpkA-5k8dA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA601_0
(LACCASE-1)		 5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens) 		4 / 5 HIS B1954
CYH B2000
ILE B2002
HIS B2005
 CU  B2610 (-3.0A)
CU  B2610 (-1.9A)
CU  B2610 (-3.3A)
CU  B2610 (-3.6A)
 0.53A 3qpkA-5k8dB:
5.0		 3qpkA-5k8dB:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB601_0
(LACCASE-1)		 5k8d COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 4 HIS A 267
CYH A 310
ILE A 312
HIS A 315
 CU  A 808 (-2.5A)
CU  A 808 (-2.2A)
CU  A 808 ( 4.9A)
CU  A 808 (-2.7A)
 0.59A 3qpkB-5k8dA:
5.8		 3qpkB-5k8dA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB601_0
(LACCASE-1)		 5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens) 		4 / 4 HIS B1954
CYH B2000
ILE B2002
HIS B2005
 CU  B2610 (-3.0A)
CU  B2610 (-1.9A)
CU  B2610 (-3.3A)
CU  B2610 (-3.6A)
 0.53A 3qpkB-5k8dB:
16.5		 3qpkB-5k8dB:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 5k8d COAGULATION FACTOR
VIII
(Homo
sapiens) 		5 / 11 ALA A 296
VAL A 257
ALA A 284
LEU A 197
LEU A 294
 None
 1.00A 3sm2B-5k8dA:
undetectable		 3sm2B-5k8dA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5k8d COAGULATION FACTOR
VIII
(Homo
sapiens) 		3 / 3 THR A 135
VAL A 137
GLU A 124
 None
 0.63A 3v4tA-5k8dA:
undetectable
3v4tD-5k8dA:
undetectable		 3v4tA-5k8dA:
22.03
3v4tD-5k8dA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5k8d COAGULATION FACTOR
VIII
COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens;
Homo
sapiens) 		5 / 12 LEU A 164
LEU B2006
ILE A 173
SER B2011
HIS B1957
 None
 1.37A 3w1wA-5k8dA:
undetectable		 3w1wA-5k8dA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1001_0
(BLUE COPPER OXIDASE
CUEO)		 5k8d COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 4 HIS A 267
CYH A 310
HIS A 232
MET A 320
 CU  A 808 (-2.5A)
CU  A 808 (-2.2A)
CU  A 808 ( 4.6A)
CU  A 808 ( 4.8A)
 1.20A 4ef3A-5k8dA:
19.2		 4ef3A-5k8dA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1001_0
(BLUE COPPER OXIDASE
CUEO)		 5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens) 		4 / 4 HIS B1954
CYH B2000
HIS B2005
MET B2010
 CU  B2610 (-3.0A)
CU  B2610 (-1.9A)
CU  B2610 (-3.6A)
CU  B2610 ( 3.9A)
 0.74A 4ef3A-5k8dB:
17.8		 4ef3A-5k8dB:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 5k8d COAGULATION FACTOR
VIII
COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens;
Homo
sapiens) 		5 / 12 GLY A 655
GLY A 686
LEU A 631
ILE B1790
ALA B1800
 None
 0.98A 4qtuB-5k8dA:
undetectable		 4qtuB-5k8dA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 5k8d COAGULATION FACTOR
VIII
COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens;
Homo
sapiens) 		5 / 12 GLY A 686
LEU A 631
ILE B1790
SER B1791
ALA B1800
 None
 1.11A 4qtuB-5k8dA:
undetectable		 4qtuB-5k8dA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		 5k8d COAGULATION FACTOR
VIII
COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens;
Homo
sapiens) 		5 / 12 ILE B1852
THR A 667
LEU B1945
LEU B1789
LEU B1855
 None
 1.41A 4qynB-5k8dB:
undetectable		 4qynB-5k8dB:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens) 		5 / 11 PHE B1735
LEU B1878
LEU B1758
GLY B1757
ALA B1920
 None
 1.27A 5fctA-5k8dB:
undetectable		 5fctA-5k8dB:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 5k8d COAGULATION FACTOR
VIII
COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens) 		4 / 5 HIS B1957
HIS A  99
VAL A 101
ALA B1974
 None
 1.15A 5i3bB-5k8dB:
undetectable		 5i3bB-5k8dB:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 5k8d COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 8 THR A  49
SER A 170
SER A 207
SER A 160
 None
 1.02A 5l4eA-5k8dA:
undetectable
5l4eB-5k8dA:
undetectable
5l4eC-5k8dA:
undetectable
5l4eD-5k8dA:
undetectable
5l4eE-5k8dA:
undetectable		 5l4eA-5k8dA:
18.31
5l4eB-5k8dA:
18.31
5l4eC-5k8dA:
18.31
5l4eD-5k8dA:
18.31
5l4eE-5k8dA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M6G_A_SORA711_0
(BETA-GLUCOSIDASE)		 5k8d COAGULATION FACTOR
VIII
(Homo
sapiens) 		5 / 12 LEU A 690
GLY A 691
PHE A 658
HIS A 660
MET A 682
 None
 1.32A 5m6gA-5k8dA:
undetectable		 5m6gA-5k8dA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA504_0
(LACCASE 2)		 5k8d COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 4 HIS A 267
CYH A 310
ILE A 312
HIS A 315
 CU  A 808 (-2.5A)
CU  A 808 (-2.2A)
CU  A 808 ( 4.9A)
CU  A 808 (-2.7A)
 0.64A 5mejA-5k8dA:
10.8		 5mejA-5k8dA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA504_0
(LACCASE 2)		 5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens) 		4 / 4 HIS B1954
CYH B2000
ILE B2002
HIS B2005
 CU  B2610 (-3.0A)
CU  B2610 (-1.9A)
CU  B2610 (-3.3A)
CU  B2610 (-3.6A)
 0.63A 5mejA-5k8dB:
13.1		 5mejA-5k8dB:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA504_0
(LACCASE 2)		 5k8d COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 4 HIS A 267
CYH A 310
ILE A 312
HIS A 315
 CU  A 808 (-2.5A)
CU  A 808 (-2.2A)
CU  A 808 ( 4.9A)
CU  A 808 (-2.7A)
 0.66A 5mewA-5k8dA:
10.8		 5mewA-5k8dA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA504_0
(LACCASE 2)		 5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens) 		4 / 4 HIS B1954
CYH B2000
ILE B2002
HIS B2005
 CU  B2610 (-3.0A)
CU  B2610 (-1.9A)
CU  B2610 (-3.3A)
CU  B2610 (-3.6A)
 0.61A 5mewA-5k8dB:
13.1		 5mewA-5k8dB:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA504_0
(LACCASE 2)		 5k8d COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 4 HIS A 267
CYH A 310
ILE A 312
HIS A 315
 CU  A 808 (-2.5A)
CU  A 808 (-2.2A)
CU  A 808 ( 4.9A)
CU  A 808 (-2.7A)
 0.67A 5mhuA-5k8dA:
10.7		 5mhuA-5k8dA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA504_0
(LACCASE 2)		 5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens) 		4 / 4 HIS B1954
CYH B2000
ILE B2002
HIS B2005
 CU  B2610 (-3.0A)
CU  B2610 (-1.9A)
CU  B2610 (-3.3A)
CU  B2610 (-3.6A)
 0.60A 5mhuA-5k8dB:
13.0		 5mhuA-5k8dB:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA504_0
(LACCASE 2)		 5k8d COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 4 HIS A 267
CYH A 310
ILE A 312
HIS A 315
 CU  A 808 (-2.5A)
CU  A 808 (-2.2A)
CU  A 808 ( 4.9A)
CU  A 808 (-2.7A)
 0.68A 5mhvA-5k8dA:
9.4		 5mhvA-5k8dA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA504_0
(LACCASE 2)		 5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens) 		4 / 4 HIS B1954
CYH B2000
ILE B2002
HIS B2005
 CU  B2610 (-3.0A)
CU  B2610 (-1.9A)
CU  B2610 (-3.3A)
CU  B2610 (-3.6A)
 0.60A 5mhvA-5k8dB:
18.5		 5mhvA-5k8dB:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA604_0
(LACCASE 2)		 5k8d COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 4 HIS A 267
CYH A 310
ILE A 312
HIS A 315
 CU  A 808 (-2.5A)
CU  A 808 (-2.2A)
CU  A 808 ( 4.9A)
CU  A 808 (-2.7A)
 0.67A 5mhwA-5k8dA:
9.4		 5mhwA-5k8dA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA604_0
(LACCASE 2)		 5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens) 		4 / 4 HIS B1954
CYH B2000
ILE B2002
HIS B2005
 CU  B2610 (-3.0A)
CU  B2610 (-1.9A)
CU  B2610 (-3.3A)
CU  B2610 (-3.6A)
 0.60A 5mhwA-5k8dB:
18.5		 5mhwA-5k8dB:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA604_0
(LACCASE 2)		 5k8d COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 4 HIS A 267
CYH A 310
ILE A 312
HIS A 315
 CU  A 808 (-2.5A)
CU  A 808 (-2.2A)
CU  A 808 ( 4.9A)
CU  A 808 (-2.7A)
 0.68A 5mhxA-5k8dA:
10.7		 5mhxA-5k8dA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA604_0
(LACCASE 2)		 5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens) 		4 / 4 HIS B1954
CYH B2000
ILE B2002
HIS B2005
 CU  B2610 (-3.0A)
CU  B2610 (-1.9A)
CU  B2610 (-3.3A)
CU  B2610 (-3.6A)
 0.60A 5mhxA-5k8dB:
13.1		 5mhxA-5k8dB:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA604_0
(LACCASE 2)		 5k8d COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 4 HIS A 267
CYH A 310
ILE A 312
HIS A 315
 CU  A 808 (-2.5A)
CU  A 808 (-2.2A)
CU  A 808 ( 4.9A)
CU  A 808 (-2.7A)
 0.67A 5mhyA-5k8dA:
10.8		 5mhyA-5k8dA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA604_0
(LACCASE 2)		 5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens) 		4 / 4 HIS B1954
CYH B2000
ILE B2002
HIS B2005
 CU  B2610 (-3.0A)
CU  B2610 (-1.9A)
CU  B2610 (-3.3A)
CU  B2610 (-3.6A)
 0.60A 5mhyA-5k8dB:
13.1		 5mhyA-5k8dB:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA604_0
(LACCASE 2)		 5k8d COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 4 HIS A 267
CYH A 310
ILE A 312
HIS A 315
 CU  A 808 (-2.5A)
CU  A 808 (-2.2A)
CU  A 808 ( 4.9A)
CU  A 808 (-2.7A)
 0.67A 5mhzA-5k8dA:
9.4		 5mhzA-5k8dA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA604_0
(LACCASE 2)		 5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens) 		4 / 4 HIS B1954
CYH B2000
ILE B2002
HIS B2005
 CU  B2610 (-3.0A)
CU  B2610 (-1.9A)
CU  B2610 (-3.3A)
CU  B2610 (-3.6A)
 0.59A 5mhzA-5k8dB:
13.1		 5mhzA-5k8dB:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA604_0
(LACCASE 2)		 5k8d COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 4 HIS A 267
CYH A 310
ILE A 312
HIS A 315
 CU  A 808 (-2.5A)
CU  A 808 (-2.2A)
CU  A 808 ( 4.9A)
CU  A 808 (-2.7A)
 0.67A 5mi1A-5k8dA:
10.8		 5mi1A-5k8dA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA604_0
(LACCASE 2)		 5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens) 		4 / 4 HIS B1954
CYH B2000
ILE B2002
HIS B2005
 CU  B2610 (-3.0A)
CU  B2610 (-1.9A)
CU  B2610 (-3.3A)
CU  B2610 (-3.6A)
 0.59A 5mi1A-5k8dB:
13.1		 5mi1A-5k8dB:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA604_0
(LACCASE 2)		 5k8d COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 4 HIS A 267
CYH A 310
ILE A 312
HIS A 315
 CU  A 808 (-2.5A)
CU  A 808 (-2.2A)
CU  A 808 ( 4.9A)
CU  A 808 (-2.7A)
 0.67A 5mi2A-5k8dA:
10.8		 5mi2A-5k8dA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA604_0
(LACCASE 2)		 5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens) 		4 / 4 HIS B1954
CYH B2000
ILE B2002
HIS B2005
 CU  B2610 (-3.0A)
CU  B2610 (-1.9A)
CU  B2610 (-3.3A)
CU  B2610 (-3.6A)
 0.59A 5mi2A-5k8dB:
13.1		 5mi2A-5k8dB:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA604_0
(LACCASE 2)		 5k8d COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 4 HIS A 267
CYH A 310
ILE A 312
HIS A 315
 CU  A 808 (-2.5A)
CU  A 808 (-2.2A)
CU  A 808 ( 4.9A)
CU  A 808 (-2.7A)
 0.68A 5miaA-5k8dA:
10.8		 5miaA-5k8dA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA604_0
(LACCASE 2)		 5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens) 		4 / 4 HIS B1954
CYH B2000
ILE B2002
HIS B2005
 CU  B2610 (-3.0A)
CU  B2610 (-1.9A)
CU  B2610 (-3.3A)
CU  B2610 (-3.6A)
 0.60A 5miaA-5k8dB:
13.1		 5miaA-5k8dB:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA604_0
(LACCASE 2)		 5k8d COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 4 HIS A 267
CYH A 310
ILE A 312
HIS A 315
 CU  A 808 (-2.5A)
CU  A 808 (-2.2A)
CU  A 808 ( 4.9A)
CU  A 808 (-2.7A)
 0.67A 5mibA-5k8dA:
10.8		 5mibA-5k8dA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA604_0
(LACCASE 2)		 5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens) 		4 / 4 HIS B1954
CYH B2000
ILE B2002
HIS B2005
 CU  B2610 (-3.0A)
CU  B2610 (-1.9A)
CU  B2610 (-3.3A)
CU  B2610 (-3.6A)
 0.59A 5mibA-5k8dB:
18.5		 5mibA-5k8dB:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA604_0
(LACCASE 2)		 5k8d COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 4 HIS A 267
CYH A 310
ILE A 312
HIS A 315
 CU  A 808 (-2.5A)
CU  A 808 (-2.2A)
CU  A 808 ( 4.9A)
CU  A 808 (-2.7A)
 0.67A 5micA-5k8dA:
10.8		 5micA-5k8dA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA604_0
(LACCASE 2)		 5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens) 		4 / 4 HIS B1954
CYH B2000
ILE B2002
HIS B2005
 CU  B2610 (-3.0A)
CU  B2610 (-1.9A)
CU  B2610 (-3.3A)
CU  B2610 (-3.6A)
 0.59A 5micA-5k8dB:
13.1		 5micA-5k8dB:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA604_0
(LACCASE 2)		 5k8d COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 4 HIS A 267
CYH A 310
ILE A 312
HIS A 315
 CU  A 808 (-2.5A)
CU  A 808 (-2.2A)
CU  A 808 ( 4.9A)
CU  A 808 (-2.7A)
 0.68A 5midA-5k8dA:
8.0		 5midA-5k8dA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA604_0
(LACCASE 2)		 5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens) 		4 / 4 HIS B1954
CYH B2000
ILE B2002
HIS B2005
 CU  B2610 (-3.0A)
CU  B2610 (-1.9A)
CU  B2610 (-3.3A)
CU  B2610 (-3.6A)
 0.59A 5midA-5k8dB:
18.5		 5midA-5k8dB:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA604_0
(LACCASE 2)		 5k8d COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 4 HIS A 267
CYH A 310
ILE A 312
HIS A 315
 CU  A 808 (-2.5A)
CU  A 808 (-2.2A)
CU  A 808 ( 4.9A)
CU  A 808 (-2.7A)
 0.68A 5mieA-5k8dA:
10.8		 5mieA-5k8dA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA604_0
(LACCASE 2)		 5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens) 		4 / 4 HIS B1954
CYH B2000
ILE B2002
HIS B2005
 CU  B2610 (-3.0A)
CU  B2610 (-1.9A)
CU  B2610 (-3.3A)
CU  B2610 (-3.6A)
 0.59A 5mieA-5k8dB:
13.1		 5mieA-5k8dB:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA604_0
(LACCASE 2)		 5k8d COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 4 HIS A 267
CYH A 310
ILE A 312
HIS A 315
 CU  A 808 (-2.5A)
CU  A 808 (-2.2A)
CU  A 808 ( 4.9A)
CU  A 808 (-2.7A)
 0.68A 5migA-5k8dA:
10.8		 5migA-5k8dA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA604_0
(LACCASE 2)		 5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens) 		4 / 4 HIS B1954
CYH B2000
ILE B2002
HIS B2005
 CU  B2610 (-3.0A)
CU  B2610 (-1.9A)
CU  B2610 (-3.3A)
CU  B2610 (-3.6A)
 0.58A 5migA-5k8dB:
13.1		 5migA-5k8dB:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)		 5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens) 		5 / 10 TYR B1837
ILE B1771
VAL B1773
TYR B1786
ILE B1790
 None
 1.39A 5mzrA-5k8dB:
undetectable		 5mzrA-5k8dB:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_C_PFLC409_1
(PROTON-GATED ION
CHANNEL)		 5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens) 		5 / 10 TYR B1837
ILE B1771
VAL B1773
TYR B1786
ILE B1790
 None
 1.39A 5mzrC-5k8dB:
undetectable		 5mzrC-5k8dB:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 5k8d COAGULATION FACTOR
VIII
COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens;
Homo
sapiens) 		4 / 7 GLY A 655
SER A 710
GLU B1793
ASN B1805
 None
 1.02A 5n5dB-5k8dA:
undetectable		 5n5dB-5k8dA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)		 5k8d COAGULATION FACTOR
VIII
(Homo
sapiens) 		3 / 3 LYS A  47
TRP A 208
SER A  13
 None
 1.30A 5nwwA-5k8dA:
undetectable		 5nwwA-5k8dA:
4.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6N_A_SALA505_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens) 		4 / 8 SER B2296
HIS B2031
GLN B2036
MET B2079
 None
 1.49A 5u6nA-5k8dB:
undetectable		 5u6nA-5k8dB:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens) 		3 / 3 GLU B2181
HIS B2211
ARG B2320
 None
 0.91A 5uunA-5k8dB:
undetectable		 5uunA-5k8dB:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5k8d COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 5 MET A 260
TYR A 158
GLY A 174
GLY A  73
 None
 1.05A 5x7pA-5k8dA:
undetectable		 5x7pA-5k8dA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5k8d COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 5 TYR A 533
TYR A 532
GLY A 549
GLY A 450
 None
 0.88A 5x7pA-5k8dA:
undetectable		 5x7pA-5k8dA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens) 		4 / 5 MET B1947
TYR B1837
GLY B1853
GLY B1760
 None
 1.21A 5x7pA-5k8dB:
undetectable		 5x7pA-5k8dB:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5k8d COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 6 TYR A 533
TYR A 532
GLY A 549
GLY A 450
 None
 0.91A 5x7pB-5k8dA:
undetectable		 5x7pB-5k8dA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA502_1
(CYTOCHROME P450 2C9)		 5k8d COAGULATION FACTOR
VIII
(Homo
sapiens) 		4 / 6 PRO A 505
GLY A 506
ASN A 467
LYS A 466
 None
 1.00A 5xxiA-5k8dA:
undetectable		 5xxiA-5k8dA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 5k8d COAGULATION FACTOR
VIII
(Homo
sapiens) 		3 / 3 HIS A 315
HIS A 267
HIS A 232
 CU  A 808 (-2.7A)
CU  A 808 (-2.5A)
CU  A 808 ( 4.6A)
 0.59A 5zrdA-5k8dA:
undetectable		 5zrdA-5k8dA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens) 		6 / 12 LEU B1756
GLY B1853
GLY B1760
ILE B1763
PHE B1879
LEU B1856
 None
 1.29A 6ectA-5k8dB:
undetectable		 6ectA-5k8dB:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)		 5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens) 		3 / 3 HIS B2005
ARG B1917
ILE B1882
 CU  B2610 (-3.6A)
None
None
 0.80A 6fgdA-5k8dB:
undetectable		 6fgdA-5k8dB:
19.39