SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5k8f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 5k8f ACETYL-COENZYME A
SYNTHETASE
(Cryptococcus
neoformans) 		3 / 3 TRP A 170
ALA A 126
VAL A 354
 None
 0.81A 1bdwA-5k8fA:
undetectable
1bdwB-5k8fA:
undetectable		 1bdwA-5k8fA:
3.29
1bdwB-5k8fA:
3.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 5k8f ACETYL-COENZYME A
SYNTHETASE
(Cryptococcus
neoformans) 		5 / 12 PHE A 370
ALA A 327
ALA A 353
THR A 120
ARG A 325
 None
 1.23A 1cbrA-5k8fA:
undetectable		 1cbrA-5k8fA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 5k8f ACETYL-COENZYME A
SYNTHETASE
(Cryptococcus
neoformans) 		5 / 12 PHE A 370
ALA A 327
ALA A 353
THR A 120
ARG A 325
 None
 1.23A 1cbrB-5k8fA:
undetectable		 1cbrB-5k8fA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 5k8f ACETYL-COENZYME A
SYNTHETASE
(Cryptococcus
neoformans) 		5 / 12 TYR A 343
TYR A 106
TYR A  78
LEU A  75
HIS A 186
 None
EDO  A 707 ( 4.5A)
EDO  A 707 (-4.6A)
None
None
 0.94A 1fmlA-5k8fA:
undetectable		 1fmlA-5k8fA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 5k8f ACETYL-COENZYME A
SYNTHETASE
(Cryptococcus
neoformans) 		5 / 11 PHE A 523
ILE A 500
ASP A  93
GLY A  88
PHE A  89
 None
 1.40A 1hvyC-5k8fA:
undetectable		 1hvyC-5k8fA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 5k8f ACETYL-COENZYME A
SYNTHETASE
(Cryptococcus
neoformans) 		5 / 9 PHE A 523
ILE A 500
ASP A  93
GLY A  88
PHE A  89
 None
 1.36A 1i00A-5k8fA:
undetectable		 1i00A-5k8fA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 5k8f ACETYL-COENZYME A
SYNTHETASE
(Cryptococcus
neoformans) 		5 / 11 PHE A 523
ILE A 500
ASP A  93
GLY A  88
PHE A  89
 None
 1.40A 1ju6A-5k8fA:
undetectable		 1ju6A-5k8fA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 5k8f ACETYL-COENZYME A
SYNTHETASE
(Cryptococcus
neoformans) 		4 / 4 LEU A 198
VAL A 202
CYH A 205
ALA A 161
 None
 1.03A 1mz9E-5k8fA:
undetectable		 1mz9E-5k8fA:
5.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 5k8f ACETYL-COENZYME A
SYNTHETASE
(Cryptococcus
neoformans) 		5 / 11 THR A 225
VAL A 242
VAL A 244
ARG A 258
ASP A 259
 None
 1.29A 1t6zA-5k8fA:
2.7		 1t6zA-5k8fA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 5k8f ACETYL-COENZYME A
SYNTHETASE
(Cryptococcus
neoformans) 		4 / 8 TYR A 628
VAL A 575
GLY A 576
ILE A 649
 None
 0.81A 2a1mB-5k8fA:
undetectable		 2a1mB-5k8fA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 5k8f ACETYL-COENZYME A
SYNTHETASE
(Cryptococcus
neoformans) 		4 / 7 ARG A 643
LEU A 646
VAL A 630
MET A 592
 EDO  A 708 (-3.4A)
None
None
None
 1.22A 2hrcA-5k8fA:
undetectable		 2hrcA-5k8fA:
18.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 5k8f ACETYL-COENZYME A
SYNTHETASE
(Cryptococcus
neoformans) 		4 / 5 THR A 336
VAL A 411
GLY A 412
TRP A 439
 6R9  A 704 ( 4.9A)
ATP  A 703 (-4.8A)
ATP  A 703 ( 3.4A)
6R9  A 704 ( 3.5A)
 0.31A 2p2fA-5k8fA:
57.2		 2p2fA-5k8fA:
48.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)		 5k8f ACETYL-COENZYME A
SYNTHETASE
(Cryptococcus
neoformans) 		5 / 9 PHE A 523
ILE A 500
GLY A  92
PHE A  89
THR A 514
 None
 1.37A 2tsrD-5k8fA:
undetectable		 2tsrD-5k8fA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VD0_B_D27B1200_0
(GLUTATHIONE-REQUIRIN
G PROSTAGLANDIN D
SYNTHASE)		 5k8f ACETYL-COENZYME A
SYNTHETASE
(Cryptococcus
neoformans) 		5 / 10 ALA A 347
TYR A 272
CYH A 145
THR A 144
LEU A 140
 None
 1.36A 2vd0B-5k8fA:
undetectable		 2vd0B-5k8fA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 5k8f ACETYL-COENZYME A
SYNTHETASE
(Cryptococcus
neoformans) 		4 / 7 ILE A 335
VAL A 411
GLY A 412
THR A 441
 None
ATP  A 703 (-4.8A)
ATP  A 703 ( 3.4A)
ATP  A 703 ( 3.7A)
 0.54A 2wd9A-5k8fA:
39.5		 2wd9A-5k8fA:
28.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 5k8f ACETYL-COENZYME A
SYNTHETASE
(Cryptococcus
neoformans) 		4 / 8 ILE A 335
VAL A 411
GLY A 412
THR A 441
 None
ATP  A 703 (-4.8A)
ATP  A 703 ( 3.4A)
ATP  A 703 ( 3.7A)
 0.55A 2wd9B-5k8fA:
35.8		 2wd9B-5k8fA:
28.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 5k8f ACETYL-COENZYME A
SYNTHETASE
(Cryptococcus
neoformans) 		5 / 10 THR A 289
ILE A 335
VAL A 411
GLY A 412
THR A 441
 ATP  A 703 (-3.8A)
None
ATP  A 703 (-4.8A)
ATP  A 703 ( 3.4A)
ATP  A 703 ( 3.7A)
 0.73A 2wd9C-5k8fA:
38.8		 2wd9C-5k8fA:
28.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 5k8f ACETYL-COENZYME A
SYNTHETASE
(Cryptococcus
neoformans) 		5 / 10 TRP A 334
ILE A 335
VAL A 411
GLY A 412
THR A 441
 6R9  A 704 ( 4.2A)
None
ATP  A 703 (-4.8A)
ATP  A 703 ( 3.4A)
ATP  A 703 ( 3.7A)
 0.58A 2wd9C-5k8fA:
38.8		 2wd9C-5k8fA:
28.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		 5k8f ACETYL-COENZYME A
SYNTHETASE
(Cryptococcus
neoformans) 		4 / 6 SER A 339
VAL A 411
TYR A 380
TRP A 334
 None
ATP  A 703 (-4.8A)
None
6R9  A 704 ( 4.2A)
 1.16A 2x45A-5k8fA:
undetectable		 2x45A-5k8fA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		 5k8f ACETYL-COENZYME A
SYNTHETASE
(Cryptococcus
neoformans) 		4 / 7 SER A 339
VAL A 411
TYR A 380
TRP A 334
 None
ATP  A 703 (-4.8A)
None
6R9  A 704 ( 4.2A)
 1.16A 2x45C-5k8fA:
undetectable		 2x45C-5k8fA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		 5k8f ACETYL-COENZYME A
SYNTHETASE
(Cryptococcus
neoformans) 		4 / 7 SER A 339
VAL A 411
TYR A 380
TRP A 334
 None
ATP  A 703 (-4.8A)
None
6R9  A 704 ( 4.2A)
 1.17A 3bu1A-5k8fA:
undetectable		 3bu1A-5k8fA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_F_SAMF300_0
(PUTATIVE RRNA
METHYLASE)		 5k8f ACETYL-COENZYME A
SYNTHETASE
(Cryptococcus
neoformans) 		5 / 12 GLY A 412
ASP A 436
ILE A 335
GLY A 444
THR A 310
 ATP  A 703 ( 3.4A)
6R9  A 704 ( 3.5A)
None
None
None
 1.18A 3eeyF-5k8fA:
undetectable		 3eeyF-5k8fA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)		 5k8f ACETYL-COENZYME A
SYNTHETASE
(Cryptococcus
neoformans) 		3 / 3 TYR A 380
TYR A 423
ILE A 386
 None
 0.85A 3eteA-5k8fA:
2.9
3eteB-5k8fA:
6.0		 3eteA-5k8fA:
22.46
3eteB-5k8fA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA804_1
(CATALASE-PEROXIDASE)		 5k8f ACETYL-COENZYME A
SYNTHETASE
(Cryptococcus
neoformans) 		3 / 3 ASN A 250
GLU A 215
ARG A 217
 None
 1.07A 3wxoA-5k8fA:
undetectable		 3wxoA-5k8fA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 5k8f ACETYL-COENZYME A
SYNTHETASE
(Cryptococcus
neoformans) 		5 / 12 ILE A 211
ALA A 172
THR A 225
PHE A 193
LEU A 198
 None
 1.30A 4cd2A-5k8fA:
undetectable		 4cd2A-5k8fA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5k8f ACETYL-COENZYME A
SYNTHETASE
(Cryptococcus
neoformans) 		4 / 5 ARG A 643
VAL A 559
LEU A 563
SER A 561
 EDO  A 708 (-3.4A)
None
None
None
 1.29A 4e1gA-5k8fA:
undetectable		 4e1gA-5k8fA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 5k8f ACETYL-COENZYME A
SYNTHETASE
(Cryptococcus
neoformans) 		5 / 12 PHE A 285
TYR A 306
ASN A 107
LEU A 346
ILE A 342
 None
 1.37A 4k39A-5k8fA:
undetectable		 4k39A-5k8fA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_E_SPME202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5k8f ACETYL-COENZYME A
SYNTHETASE
(Cryptococcus
neoformans) 		4 / 5 GLU A 125
GLU A 356
GLU A 128
GLU A 131
 None
 1.32A 4r87E-5k8fA:
undetectable		 4r87E-5k8fA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_E_SPME202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5k8f ACETYL-COENZYME A
SYNTHETASE
(Cryptococcus
neoformans) 		4 / 5 GLU A 356
GLU A 125
GLU A 131
GLU A 128
 None
 1.33A 4r87E-5k8fA:
undetectable		 4r87E-5k8fA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 5k8f ACETYL-COENZYME A
SYNTHETASE
(Cryptococcus
neoformans) 		3 / 3 GLU A  73
TYR A 316
GLU A  54
 None
 0.77A 4ryaA-5k8fA:
undetectable		 4ryaA-5k8fA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 5k8f ACETYL-COENZYME A
SYNTHETASE
(Cryptococcus
neoformans) 		4 / 6 ARG A 199
ARG A 201
ASP A 200
VAL A 229
 None
 1.41A 4xqeA-5k8fA:
undetectable		 4xqeA-5k8fA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5k8f ACETYL-COENZYME A
SYNTHETASE
(Cryptococcus
neoformans) 		4 / 5 VAL A  84
TYR A 343
ILE A 341
THR A 441
 None
None
None
ATP  A 703 ( 3.7A)
 1.06A 4ze1A-5k8fA:
undetectable		 4ze1A-5k8fA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 5k8f ACETYL-COENZYME A
SYNTHETASE
(Cryptococcus
neoformans) 		4 / 6 LEU A 102
SER A 302
PRO A 283
PHE A 285
 None
 1.23A 5b8iA-5k8fA:
undetectable		 5b8iA-5k8fA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5k8f ACETYL-COENZYME A
SYNTHETASE
(Cryptococcus
neoformans) 		5 / 12 ASP A 324
ALA A 320
PRO A 452
GLY A 409
SER A 410
 None
EDO  A 705 (-4.3A)
None
None
None
 1.16A 5hfjF-5k8fA:
2.3		 5hfjF-5k8fA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_2
(FK506-BINDING
PROTEIN 1)		 5k8f ACETYL-COENZYME A
SYNTHETASE
(Cryptococcus
neoformans) 		5 / 11 PHE A 318
VAL A 435
ILE A 434
TYR A 423
ILE A 386
 None
 1.18A 5hw8G-5k8fA:
undetectable		 5hw8G-5k8fA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5k8f ACETYL-COENZYME A
SYNTHETASE
(Cryptococcus
neoformans) 		3 / 3 GLY A 528
THR A 384
PRO A 414
 None
None
6R9  A 704 (-3.3A)
 0.62A 5v5zA-5k8fA:
undetectable		 5v5zA-5k8fA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5k8f ACETYL-COENZYME A
SYNTHETASE
(Cryptococcus
neoformans) 		5 / 9 GLY A 344
LEU A 314
ILE A 350
GLY A 349
PHE A 370
 None
None
EDO  A 705 ( 4.8A)
EDO  A 706 ( 4.9A)
None
 0.90A 5vkqC-5k8fA:
undetectable
5vkqD-5k8fA:
undetectable		 5vkqC-5k8fA:
17.64
5vkqD-5k8fA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 5k8f ACETYL-COENZYME A
SYNTHETASE
(Cryptococcus
neoformans) 		5 / 10 PHE A 523
ILE A 500
ASP A  93
GLY A  88
PHE A  89
 None
 1.41A 5x66D-5k8fA:
undetectable		 5x66D-5k8fA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5k8f ACETYL-COENZYME A
SYNTHETASE
(Cryptococcus
neoformans) 		5 / 9 ALA A  71
PHE A 467
GLY A 468
SER A 499
GLY A 305
 None
 1.23A 6awoA-5k8fA:
undetectable		 6awoA-5k8fA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5k8f ACETYL-COENZYME A
SYNTHETASE
(Cryptococcus
neoformans) 		5 / 9 ALA A  71
PHE A 467
GLY A 468
SER A 499
GLY A 305
 None
 1.23A 6awqA-5k8fA:
undetectable		 6awqA-5k8fA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11802_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
UL4
RIBOSOMAL PROTEIN
UL15
RIBOSOMAL PROTEIN
EL15)		 5k8f ACETYL-COENZYME A
SYNTHETASE
(Cryptococcus
neoformans) 		3 / 3 ARG A 644
LYS A 297
ARG A 647
 None
ATP  A 703 (-2.8A)
None
 1.13A 6az3C-5k8fA:
undetectable
6az3L-5k8fA:
undetectable
6az3M-5k8fA:
undetectable		 6az3C-5k8fA:
8.17
6az3L-5k8fA:
7.33
6az3M-5k8fA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 5k8f ACETYL-COENZYME A
SYNTHETASE
(Cryptococcus
neoformans) 		3 / 3 LYS A 226
VAL A 252
ASP A 230
 None
 0.54A 6fgdA-5k8fA:
4.5		 6fgdA-5k8fA:
20.90