SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5k8g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 5k8g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis) 		5 / 12 SER A 282
VAL A 283
GLY A 284
VAL A 346
MET A 304
 None
 1.25A 1a27A-5k8gA:
undetectable		 1a27A-5k8gA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)		 5k8g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis) 		5 / 11 THR A  56
GLY A  32
VAL A  84
ASP A  43
VAL A  45
 None
None
None
CA  A 615 ( 4.7A)
None
 1.18A 1akdA-5k8gA:
undetectable		 1akdA-5k8gA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FPQ_A_SAMA1699_0
(ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE)		 5k8g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis) 		5 / 10 ASN A 242
LEU A 393
VAL A 283
ALA A 245
TRP A 219
 CA  A 614 (-2.9A)
None
None
CA  A 613 (-4.4A)
None
 1.25A 1fpqA-5k8gA:
undetectable		 1fpqA-5k8gA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 5k8g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis) 		5 / 11 GLY A 452
GLY A 455
GLU A 482
ILE A 502
GLY A 437
 None
 1.01A 1jg3A-5k8gA:
undetectable		 1jg3A-5k8gA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_B_ADNB550_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 5k8g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis) 		5 / 11 GLY A 452
GLY A 455
GLU A 482
ILE A 502
GLY A 437
 None
 1.00A 1jg3B-5k8gA:
undetectable		 1jg3B-5k8gA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MIC_A_DVAA6_0
(GRAMICIDIN A)		 5k8g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis) 		3 / 3 ALA A  12
VAL A  10
TRP A  64
 None
 0.67A 1micA-5k8gA:
undetectable
1micB-5k8gA:
undetectable		 1micA-5k8gA:
3.04
1micB-5k8gA:
3.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 5k8g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis) 		5 / 11 THR A  56
GLY A  32
VAL A  84
ASP A  43
VAL A  45
 None
None
None
CA  A 615 ( 4.7A)
None
 1.14A 1phgA-5k8gA:
undetectable		 1phgA-5k8gA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 5k8g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis) 		5 / 12 SER A 257
HIS A 288
ASP A 342
HIS A 328
VAL A 293
 None
None
CA  A 608 ( 2.9A)
None
None
 1.36A 1uobA-5k8gA:
undetectable		 1uobA-5k8gA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5k8g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis) 		3 / 3 GLU A 409
THR A 408
LEU A 500
 None
CA  A 616 (-3.7A)
None
 0.58A 1v8bC-5k8gA:
undetectable		 1v8bC-5k8gA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 5k8g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis) 		3 / 3 GLY A 284
GLU A 392
ASP A 266
 None
None
CA  A 614 (-3.0A)
 0.68A 2b25B-5k8gA:
undetectable		 2b25B-5k8gA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		 5k8g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis) 		4 / 7 ILE A 364
ARG A 368
PHE A 367
PHE A 326
 None
 0.86A 2q6hA-5k8gA:
undetectable		 2q6hA-5k8gA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 5k8g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis) 		4 / 7 ILE A 364
ARG A 368
PHE A 367
PHE A 326
 None
 0.86A 2qb4A-5k8gA:
undetectable		 2qb4A-5k8gA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 5k8g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis) 		4 / 8 ILE A  19
SER A 107
ASP A  16
SER A 103
 None
None
CA  A 609 (-2.9A)
CA  A 610 ( 4.8A)
 1.09A 2zw9B-5k8gA:
undetectable		 2zw9B-5k8gA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5k8g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis) 		4 / 8 SER A 441
SER A 442
ASN A 443
GLN A 489
 None
 0.82A 4af0A-5k8gA:
undetectable		 4af0A-5k8gA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)		 5k8g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis) 		5 / 10 THR A  56
GLY A  32
VAL A  84
ASP A  43
VAL A  45
 None
None
None
CA  A 615 ( 4.7A)
None
 1.15A 4c9nB-5k8gA:
undetectable		 4c9nB-5k8gA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 5k8g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis) 		4 / 7 THR A  56
VAL A  84
ASP A  43
VAL A  45
 None
None
CA  A 615 ( 4.7A)
None
 0.89A 4cp4A-5k8gA:
undetectable		 4cp4A-5k8gA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 5k8g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis) 		3 / 3 ASP A 475
ARG A 368
PRO A 373
 None
 0.80A 4wanC-5k8gA:
undetectable		 4wanC-5k8gA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_A_ADNA302_1
(FLUORINASE)		 5k8g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis) 		4 / 7 ASP A 342
TYR A 291
PRO A 292
SER A 260
 CA  A 608 ( 2.9A)
None
CA  A 607 ( 4.8A)
CA  A 607 ( 3.9A)
 1.18A 5b6iA-5k8gA:
undetectable		 5b6iA-5k8gA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_P_DVAP5_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 5k8g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis) 		3 / 3 TYR A 262
SER A 301
TRP A 251
 None
 1.04A 5n8jD-5k8gA:
undetectable		 5n8jD-5k8gA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5k8g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis) 		5 / 12 PHE A 367
PHE A 326
THR A 349
LEU A 322
MET A 304
 None
 1.34A 5v5zA-5k8gA:
undetectable		 5v5zA-5k8gA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 5k8g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis) 		4 / 5 ILE A 189
GLN A 118
THR A 140
LEU A 122
 None
 1.12A 6f3mD-5k8gA:
undetectable		 6f3mD-5k8gA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 5k8g ANTIFREEZE PROTEIN
(Marinomonas
primoryensis) 		5 / 10 ASP A 475
SER A 474
GLY A 284
ALA A 217
VAL A 395
 None
 1.33A 6hu9L-5k8gA:
undetectable
6hu9P-5k8gA:
undetectable
6hu9T-5k8gA:
undetectable		 6hu9L-5k8gA:
22.30
6hu9P-5k8gA:
16.35
6hu9T-5k8gA:
8.38