SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5k8k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 5k8k UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Haemophilus
influenzae) 		5 / 12 HIS A 198
HIS A 196
HIS A 115
ASP A   9
ASP A 215
 LP5  A 303 ( 4.5A)
MN  A 301 ( 3.1A)
MN  A 301 ( 3.5A)
MN  A 302 ( 3.2A)
MN  A 302 ( 4.9A)
 1.23A 1a4lA-5k8kA:
undetectable		 1a4lA-5k8kA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		 5k8k UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Haemophilus
influenzae) 		4 / 4 SER A  13
VAL A  60
PHE A  46
VAL A 151
 ACT  A 304 ( 3.8A)
None
ACT  A 304 ( 4.2A)
None
 1.49A 1o86A-5k8kA:
undetectable		 1o86A-5k8kA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 5k8k UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Haemophilus
influenzae) 		4 / 5 LEU A  37
PHE A  23
VAL A  67
ALA A  31
 None
 1.21A 2cizA-5k8kA:
undetectable		 2cizA-5k8kA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 5k8k UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Haemophilus
influenzae) 		5 / 12 HIS A 196
HIS A 115
SER A   8
ASP A   9
ASP A 215
 MN  A 301 ( 3.1A)
MN  A 301 ( 3.5A)
None
MN  A 302 ( 3.2A)
MN  A 302 ( 4.9A)
 1.11A 2pgfA-5k8kA:
undetectable		 2pgfA-5k8kA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 5k8k UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Haemophilus
influenzae) 		5 / 12 HIS A 198
HIS A 115
SER A   8
ASP A   9
ASP A 215
 LP5  A 303 ( 4.5A)
MN  A 301 ( 3.5A)
None
MN  A 302 ( 3.2A)
MN  A 302 ( 4.9A)
 1.10A 2pgfA-5k8kA:
undetectable		 2pgfA-5k8kA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 5k8k UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Haemophilus
influenzae) 		4 / 6 LEU A  19
THR A  20
LEU A  43
ASP A 215
 None
None
None
MN  A 302 ( 4.9A)
 1.10A 2wm3A-5k8kA:
2.7		 2wm3A-5k8kA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		 5k8k UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Haemophilus
influenzae) 		4 / 8 PHE A  76
ASP A  50
PHE A  44
GLY A  86
 None
None
ACT  A 304 ( 4.9A)
None
 0.85A 3c0zB-5k8kA:
undetectable		 3c0zB-5k8kA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 5k8k UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Haemophilus
influenzae) 		4 / 6 PHE A  23
LEU A  37
THR A  93
LEU A  43
 None
 0.88A 3t3zA-5k8kA:
undetectable		 3t3zA-5k8kA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 5k8k UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Haemophilus
influenzae) 		4 / 6 PHE A  23
LEU A  37
THR A  93
LEU A  43
 None
 0.90A 3t3zB-5k8kA:
undetectable		 3t3zB-5k8kA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 5k8k UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE
(Haemophilus
influenzae) 		5 / 10 LEU A  10
GLY A  41
GLY A  79
LEU A  12
SER A  13
 None
None
None
None
ACT  A 304 ( 3.8A)
 1.16A 5twjB-5k8kA:
undetectable		 5twjB-5k8kA:
19.47