SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5k8o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 5k8o 5-NITROANTHRANILIC
ACID AMINOHYDROLASE
(Bradyrhizobium
sp.) 		4 / 7 LEU A 345
GLN A 346
LEU A  81
PHE A  83
 None
 1.05A 1v55C-5k8oA:
undetectable
1v55J-5k8oA:
undetectable		 1v55C-5k8oA:
17.58
1v55J-5k8oA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C2B_F_SAMF501_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)		 5k8o 5-NITROANTHRANILIC
ACID AMINOHYDROLASE
(Bradyrhizobium
sp.) 		4 / 6 ASN A  67
TRP A 132
ASN A  84
TRP A  48
 None
 1.40A 2c2bC-5k8oA:
0.0
2c2bE-5k8oA:
0.3
2c2bF-5k8oA:
0.2		 2c2bC-5k8oA:
22.94
2c2bE-5k8oA:
22.94
2c2bF-5k8oA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5k8o 5-NITROANTHRANILIC
ACID AMINOHYDROLASE
(Bradyrhizobium
sp.) 		4 / 7 LEU A 345
GLN A 346
LEU A  81
PHE A  83
 None
 1.04A 2eijC-5k8oA:
undetectable
2eijJ-5k8oA:
undetectable		 2eijC-5k8oA:
17.58
2eijJ-5k8oA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5k8o 5-NITROANTHRANILIC
ACID AMINOHYDROLASE
(Bradyrhizobium
sp.) 		4 / 7 LEU A 345
GLN A 346
LEU A  81
PHE A  83
 None
 0.97A 2eimC-5k8oA:
undetectable
2eimJ-5k8oA:
undetectable		 2eimC-5k8oA:
17.58
2eimJ-5k8oA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5k8o 5-NITROANTHRANILIC
ACID AMINOHYDROLASE
(Bradyrhizobium
sp.) 		4 / 7 LEU A 345
GLN A 346
LEU A  81
PHE A  83
 None
 0.97A 2einC-5k8oA:
undetectable
2einJ-5k8oA:
undetectable		 2einC-5k8oA:
17.58
2einJ-5k8oA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5k8o 5-NITROANTHRANILIC
ACID AMINOHYDROLASE
(Bradyrhizobium
sp.) 		4 / 6 LEU A 345
GLN A 346
LEU A  81
PHE A  83
 None
 1.01A 2einP-5k8oA:
undetectable
2einW-5k8oA:
undetectable		 2einP-5k8oA:
17.58
2einW-5k8oA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 5k8o 5-NITROANTHRANILIC
ACID AMINOHYDROLASE
(Bradyrhizobium
sp.) 		4 / 9 ILE A 276
ALA A 244
VAL A 247
GLU A 248
 None
 0.59A 2vufA-5k8oA:
undetectable		 2vufA-5k8oA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLD_A_ASCA130_0
(CYTOCHROME C')		 5k8o 5-NITROANTHRANILIC
ACID AMINOHYDROLASE
(Bradyrhizobium
sp.) 		4 / 5 ALA A 394
GLY A 127
CYH A 125
HIS A  86
 6R7  A 502 (-4.2A)
None
MN  A 501 ( 4.9A)
MN  A 501 (-3.4A)
 1.46A 2yldA-5k8oA:
undetectable		 2yldA-5k8oA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLG_A_ASCA130_0
(CYTOCHROME C')		 5k8o 5-NITROANTHRANILIC
ACID AMINOHYDROLASE
(Bradyrhizobium
sp.) 		4 / 5 ALA A 394
GLY A 127
CYH A 125
HIS A  86
 6R7  A 502 (-4.2A)
None
MN  A 501 ( 4.9A)
MN  A 501 (-3.4A)
 1.46A 2ylgA-5k8oA:
undetectable		 2ylgA-5k8oA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 5k8o 5-NITROANTHRANILIC
ACID AMINOHYDROLASE
(Bradyrhizobium
sp.) 		4 / 8 LEU A 246
ALA A 233
LEU A 234
ILE A 276
 None
 0.85A 3cldB-5k8oA:
undetectable		 3cldB-5k8oA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5k8o 5-NITROANTHRANILIC
ACID AMINOHYDROLASE
(Bradyrhizobium
sp.) 		3 / 3 CYH A 156
PRO A  34
ASP A  64
 None
 0.99A 3hlwB-5k8oA:
undetectable		 3hlwB-5k8oA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)		 5k8o 5-NITROANTHRANILIC
ACID AMINOHYDROLASE
(Bradyrhizobium
sp.) 		4 / 4 PRO A 360
THR A 361
GLY A 268
THR A 269
 None
 0.93A 3ib1A-5k8oA:
undetectable		 3ib1A-5k8oA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZWI_A_ASCA156_0
(CYTOCHROME C')		 5k8o 5-NITROANTHRANILIC
ACID AMINOHYDROLASE
(Bradyrhizobium
sp.) 		4 / 5 ALA A 394
GLY A 127
CYH A 125
HIS A  86
 6R7  A 502 (-4.2A)
None
MN  A 501 ( 4.9A)
MN  A 501 (-3.4A)
 1.46A 3zwiA-5k8oA:
undetectable		 3zwiA-5k8oA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 5k8o 5-NITROANTHRANILIC
ACID AMINOHYDROLASE
(Bradyrhizobium
sp.) 		4 / 6 GLY A  39
TYR A  46
ALA A  40
GLU A  47
 None
 0.93A 4ae1A-5k8oA:
undetectable		 4ae1A-5k8oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CIP_A_ASCA130_0
(CYTOCHROME C')		 5k8o 5-NITROANTHRANILIC
ACID AMINOHYDROLASE
(Bradyrhizobium
sp.) 		4 / 4 ALA A 394
GLY A 127
CYH A 125
HIS A  86
 6R7  A 502 (-4.2A)
None
MN  A 501 ( 4.9A)
MN  A 501 (-3.4A)
 1.47A 4cipA-5k8oA:
undetectable		 4cipA-5k8oA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5k8o 5-NITROANTHRANILIC
ACID AMINOHYDROLASE
(Bradyrhizobium
sp.) 		4 / 6 VAL A 210
ILE A 300
TRP A 253
LEU A 250
 None
 0.87A 4l1wB-5k8oA:
undetectable		 4l1wB-5k8oA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_2
(BETA-LACTAMASE
CTX-M-14)		 5k8o 5-NITROANTHRANILIC
ACID AMINOHYDROLASE
(Bradyrhizobium
sp.) 		3 / 3 CYH A 156
PRO A  34
ASP A  64
 None
 1.00A 4pm5A-5k8oA:
undetectable		 4pm5A-5k8oA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 5k8o 5-NITROANTHRANILIC
ACID AMINOHYDROLASE
(Bradyrhizobium
sp.) 		5 / 12 TYR A 388
GLY A 389
GLU A 196
LEU A  81
LEU A 420
 None
None
MN  A 501 ( 1.8A)
None
None
 1.25A 4wcxC-5k8oA:
2.2		 4wcxC-5k8oA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLI_A_ASCA202_0
(CYTOCHROME C')		 5k8o 5-NITROANTHRANILIC
ACID AMINOHYDROLASE
(Bradyrhizobium
sp.) 		4 / 5 ALA A 394
GLY A 127
CYH A 125
HIS A  86
 6R7  A 502 (-4.2A)
None
MN  A 501 ( 4.9A)
MN  A 501 (-3.4A)
 1.46A 5jliA-5k8oA:
undetectable		 5jliA-5k8oA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSL_A_ASCA202_0
(CYTOCHROME C')		 5k8o 5-NITROANTHRANILIC
ACID AMINOHYDROLASE
(Bradyrhizobium
sp.) 		4 / 4 ALA A 394
GLY A 127
CYH A 125
HIS A  86
 6R7  A 502 (-4.2A)
None
MN  A 501 ( 4.9A)
MN  A 501 (-3.4A)
 1.46A 5jslA-5k8oA:
undetectable		 5jslA-5k8oA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JT4_A_ASCA202_0
(CYTOCHROME C')		 5k8o 5-NITROANTHRANILIC
ACID AMINOHYDROLASE
(Bradyrhizobium
sp.) 		4 / 5 ALA A 394
GLY A 127
CYH A 125
HIS A  86
 6R7  A 502 (-4.2A)
None
MN  A 501 ( 4.9A)
MN  A 501 (-3.4A)
 1.45A 5jt4A-5k8oA:
undetectable		 5jt4A-5k8oA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 5k8o 5-NITROANTHRANILIC
ACID AMINOHYDROLASE
(Bradyrhizobium
sp.) 		5 / 7 ARG A 301
VAL A 270
PRO A 304
GLY A 208
TYR A 337
 None
 1.40A 5x80C-5k8oA:
undetectable
5x80D-5k8oA:
1.1		 5x80C-5k8oA:
18.63
5x80D-5k8oA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5k8o 5-NITROANTHRANILIC
ACID AMINOHYDROLASE
(Bradyrhizobium
sp.) 		4 / 7 LEU A 345
GLN A 346
LEU A  81
PHE A  83
 None
 0.95A 5z85C-5k8oA:
undetectable
5z85J-5k8oA:
undetectable		 5z85C-5k8oA:
17.58
5z85J-5k8oA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5k8o 5-NITROANTHRANILIC
ACID AMINOHYDROLASE
(Bradyrhizobium
sp.) 		4 / 7 LEU A 345
GLN A 346
LEU A  81
PHE A  83
 None
 0.92A 5zcoC-5k8oA:
undetectable
5zcoJ-5k8oA:
undetectable		 5zcoC-5k8oA:
17.58
5zcoJ-5k8oA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)		 5k8o 5-NITROANTHRANILIC
ACID AMINOHYDROLASE
(Bradyrhizobium
sp.) 		4 / 6 GLU A 316
LYS A 329
GLU A 327
ALA A 326
 None
 1.20A 6an0A-5k8oA:
undetectable		 6an0A-5k8oA:
21.60