SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5k8r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 5k8r PROTOCADHERIN
GAMMA-B3
(Homo
sapiens) 		5 / 12 LEU A 264
LEU A 232
THR A 213
GLN A 214
ILE A 252
 None
 1.16A 2jn3A-5k8rA:
undetectable		 2jn3A-5k8rA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		 5k8r PROTOCADHERIN
GAMMA-B3
(Homo
sapiens) 		5 / 11 LEU A 232
LEU A 271
ILE A 305
PHE A 262
LEU A 277
 None
 1.14A 2q6hA-5k8rA:
undetectable		 2q6hA-5k8rA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		 5k8r PROTOCADHERIN
GAMMA-B3
(Homo
sapiens) 		5 / 12 LEU A 232
LEU A 271
ILE A 305
PHE A 262
LEU A 277
 None
 1.14A 2qb4A-5k8rA:
undetectable		 2qb4A-5k8rA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		 5k8r PROTOCADHERIN
GAMMA-B3
(Homo
sapiens) 		5 / 11 LEU A 232
LEU A 271
ILE A 305
PHE A 262
LEU A 277
 None
 1.12A 2qeiA-5k8rA:
undetectable		 2qeiA-5k8rA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		 5k8r PROTOCADHERIN
GAMMA-B3
(Homo
sapiens) 		5 / 11 LEU A 232
LEU A 271
ILE A 305
PHE A 262
LEU A 277
 None
 1.13A 2qjuA-5k8rA:
undetectable		 2qjuA-5k8rA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 5k8r PROTOCADHERIN
GAMMA-B3
(Homo
sapiens) 		4 / 7 GLY A  18
ILE A   3
MET A  78
LEU A  54
 None
 0.90A 2xrhA-5k8rA:
undetectable		 2xrhA-5k8rA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 5k8r PROTOCADHERIN
GAMMA-B3
(Homo
sapiens) 		4 / 6 ASP A  58
ILE A  60
LEU A  74
GLU A  64
 None
 1.02A 2ya7A-5k8rA:
undetectable		 2ya7A-5k8rA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 5k8r PROTOCADHERIN
GAMMA-B3
(Homo
sapiens) 		4 / 6 ASP A  58
ILE A  60
LEU A  74
GLU A  64
 None
 1.00A 2ya7B-5k8rA:
undetectable		 2ya7B-5k8rA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 5k8r PROTOCADHERIN
GAMMA-B3
(Homo
sapiens) 		4 / 6 ASP A  58
ILE A  60
LEU A  74
GLU A  64
 None
 1.04A 2ya7D-5k8rA:
undetectable		 2ya7D-5k8rA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 5k8r PROTOCADHERIN
GAMMA-B3
(Homo
sapiens) 		5 / 12 LEU A  36
GLY A  18
GLY A  52
LEU A  54
LEU A  31
 None
 1.13A 3e23A-5k8rA:
undetectable		 3e23A-5k8rA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		 5k8r PROTOCADHERIN
GAMMA-B3
(Homo
sapiens) 		4 / 7 ASP A 131
ASP A  95
GLN A  94
GLU A  63
 CA  A 503 ( 3.2A)
CA  A 503 (-3.1A)
None
CA  A 503 ( 2.3A)
 1.23A 3l2vA-5k8rA:
undetectable		 3l2vA-5k8rA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		 5k8r PROTOCADHERIN
GAMMA-B3
(Homo
sapiens) 		5 / 8 ASP A 131
ASP A  95
GLN A  94
PRO A   8
GLU A  63
 CA  A 503 ( 3.2A)
CA  A 503 (-3.1A)
None
None
CA  A 503 ( 2.3A)
 1.49A 3oyaA-5k8rA:
undetectable		 3oyaA-5k8rA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_F_CAMF502_0
(CAMPHOR
5-MONOOXYGENASE)		 5k8r PROTOCADHERIN
GAMMA-B3
(Homo
sapiens) 		4 / 4 TYR A 285
THR A 273
VAL A 231
ILE A 307
 None
 1.44A 4jx1F-5k8rA:
undetectable		 4jx1F-5k8rA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 5k8r PROTOCADHERIN
GAMMA-B3
(Homo
sapiens) 		5 / 9 LEU A 117
GLY A 119
LEU A 166
LEU A 170
ALA A 116
 None
 1.10A 5dqfA-5k8rA:
undetectable		 5dqfA-5k8rA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 5k8r PROTOCADHERIN
GAMMA-B3
(Homo
sapiens) 		5 / 12 ILE A 352
HIS A 342
GLY A 350
ASP A 345
GLY A 398
 None
None
CA  A 504 ( 4.7A)
CA  A 505 ( 3.2A)
None
 1.19A 5nnaD-5k8rA:
undetectable		 5nnaD-5k8rA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WP1_A_BEZA403_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 5k8r PROTOCADHERIN
GAMMA-B3
(Homo
sapiens) 		4 / 4 GLY A 350
PHE A 348
ASN A 349
LYS A 397
 CA  A 504 ( 4.7A)
None
None
None
 1.50A 5wp1A-5k8rA:
0.0		 5wp1A-5k8rA:
23.85