SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5k8s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 5k8s CAMP-DEPENDENT
PROTEIN KINASE
REGULATORY SUBUNIT
(Plasmodium
falciparum) 		3 / 3 PRO A 412
PHE A 349
LYS A 407
 None
 1.21A 3bjwG-5k8sA:
undetectable		 3bjwG-5k8sA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRI_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 5k8s CAMP-DEPENDENT
PROTEIN KINASE
REGULATORY SUBUNIT
(Plasmodium
falciparum) 		5 / 10 TYR A 333
VAL A 398
TYR A 400
TYR A 369
ILE A 390
 None
 1.15A 3vriA-5k8sA:
undetectable
3vriC-5k8sA:
undetectable		 3vriA-5k8sA:
18.84
3vriC-5k8sA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 5k8s CAMP-DEPENDENT
PROTEIN KINASE
REGULATORY SUBUNIT
(Plasmodium
falciparum) 		5 / 12 TYR A 333
VAL A 398
TYR A 400
TYR A 369
ILE A 390
 None
 1.16A 3vrjA-5k8sA:
undetectable
3vrjC-5k8sA:
undetectable		 3vrjA-5k8sA:
18.84
3vrjC-5k8sA:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 5k8s CAMP-DEPENDENT
PROTEIN KINASE
REGULATORY SUBUNIT
(Plasmodium
falciparum) 		4 / 8 ILE A 413
PHE A 406
TYR A 374
LEU A 381
 None
 0.61A 4qopC-5k8sA:
undetectable		 4qopC-5k8sA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 5k8s CAMP-DEPENDENT
PROTEIN KINASE
REGULATORY SUBUNIT
(Plasmodium
falciparum) 		5 / 12 ILE A 351
GLY A 372
HIS A 309
VAL A 310
ILE A 312
 None
 1.08A 4rvdA-5k8sA:
undetectable		 4rvdA-5k8sA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 5k8s CAMP-DEPENDENT
PROTEIN KINASE
REGULATORY SUBUNIT
(Plasmodium
falciparum) 		5 / 12 PHE A 349
TYR A 374
VAL A 310
LEU A 307
LEU A 381
 None
 1.20A 5hbsA-5k8sA:
undetectable		 5hbsA-5k8sA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5k8s CAMP-DEPENDENT
PROTEIN KINASE
REGULATORY SUBUNIT
(Plasmodium
falciparum) 		4 / 7 ILE A 351
GLY A 372
ASP A 354
PHE A 395
 None
 1.10A 5hieA-5k8sA:
undetectable		 5hieA-5k8sA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)		 5k8s CAMP-DEPENDENT
PROTEIN KINASE
REGULATORY SUBUNIT
(Plasmodium
falciparum) 		5 / 10 ILE A 413
MET A 316
VAL A 324
TYR A 374
ILE A 312
 None
 1.44A 5mzrA-5k8sA:
undetectable		 5mzrA-5k8sA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_C_PFLC409_1
(PROTON-GATED ION
CHANNEL)		 5k8s CAMP-DEPENDENT
PROTEIN KINASE
REGULATORY SUBUNIT
(Plasmodium
falciparum) 		5 / 10 ILE A 413
MET A 316
VAL A 324
TYR A 374
ILE A 312
 None
 1.43A 5mzrC-5k8sA:
undetectable		 5mzrC-5k8sA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 5k8s CAMP-DEPENDENT
PROTEIN KINASE
REGULATORY SUBUNIT
(Plasmodium
falciparum) 		5 / 9 ILE A 413
MET A 316
VAL A 324
TYR A 374
ILE A 312
 None
 1.44A 5mzrD-5k8sA:
undetectable		 5mzrD-5k8sA:
19.59