SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5k95'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5k95 GTP CYCLOHYDROLASE
FOLE2
(Neisseria
gonorrhoeae) 		4 / 8 GLY A  95
GLY A 126
LEU A  79
LEU A  82
 None
 0.68A 4mwzB-5k95A:
undetectable		 4mwzB-5k95A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5k95 GTP CYCLOHYDROLASE
FOLE2
(Neisseria
gonorrhoeae) 		5 / 10 HIS A 135
LEU A 124
SER A 171
GLY A 176
VAL A 175
 None
 1.36A 4yb6D-5k95A:
undetectable
4yb6E-5k95A:
undetectable		 4yb6D-5k95A:
23.95
4yb6E-5k95A:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 5k95 GTP CYCLOHYDROLASE
FOLE2
(Neisseria
gonorrhoeae) 		4 / 6 GLY A  95
ASP A 130
GLY A 126
GLY A 134
 None
 0.75A 6ag0C-5k95A:
undetectable		 6ag0C-5k95A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5k95 GTP CYCLOHYDROLASE
FOLE2
(Neisseria
gonorrhoeae) 		4 / 8 ILE A 181
VAL A 236
GLU A 238
SER A 239
 None
 0.67A 6fbvC-5k95A:
undetectable		 6fbvC-5k95A:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA204_0
(N-ACETYLTRANSFERASE)		 5k95 GTP CYCLOHYDROLASE
FOLE2
(Neisseria
gonorrhoeae) 		4 / 5 LEU A  51
THR A  58
THR A  48
GLY A  22
 None
 1.20A 6gtqA-5k95A:
0.9		 6gtqA-5k95A:
24.82