SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5k9n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5k9n POLYAMINE N
ACETYLTRANSFERASE
(Drosophila
melanogaster) 		5 / 12 ASP A  49
LEU A  53
ASP A 165
VAL A 209
HIS A 127
 None
 1.34A 2x2iB-5k9nA:
undetectable		 2x2iB-5k9nA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5k9n POLYAMINE N
ACETYLTRANSFERASE
(Drosophila
melanogaster) 		3 / 3 TRP A 100
VAL A 209
ARG A 187
 None
 0.93A 3b0wA-5k9nA:
undetectable		 3b0wA-5k9nA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 5k9n POLYAMINE N
ACETYLTRANSFERASE
(Drosophila
melanogaster) 		5 / 11 ALA A 151
LEU A 216
LEU A 161
GLY A 179
LEU A 178
 None
 1.25A 3uudA-5k9nA:
undetectable		 3uudA-5k9nA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5k9n POLYAMINE N
ACETYLTRANSFERASE
(Drosophila
melanogaster) 		4 / 8 GLY A 132
VAL A 133
HIS A  29
ILE A  71
 None
 0.69A 4fglD-5k9nA:
undetectable		 4fglD-5k9nA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 5k9n POLYAMINE N
ACETYLTRANSFERASE
(Drosophila
melanogaster) 		4 / 5 LEU A  53
GLU A  51
LEU A 104
HIS A 127
 None
 1.19A 4xi3B-5k9nA:
undetectable		 4xi3B-5k9nA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)		 5k9n POLYAMINE N
ACETYLTRANSFERASE
(Drosophila
melanogaster) 		5 / 11 ALA A 151
LEU A 216
LEU A 161
GLY A 179
LEU A 178
 None
 1.26A 5dxgB-5k9nA:
undetectable		 5dxgB-5k9nA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 5k9n POLYAMINE N
ACETYLTRANSFERASE
(Drosophila
melanogaster) 		5 / 12 GLY A  17
LEU A  53
ASN A  56
ASP A  49
MET A  23
 None
 1.31A 5yn6A-5k9nA:
undetectable		 5yn6A-5k9nA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 5k9n POLYAMINE N
ACETYLTRANSFERASE
(Drosophila
melanogaster) 		5 / 12 GLY A  17
LEU A  53
ASN A  56
ASP A  49
MET A  23
 None
 1.29A 5ynmA-5k9nA:
undetectable		 5ynmA-5k9nA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 5k9n POLYAMINE N
ACETYLTRANSFERASE
(Drosophila
melanogaster) 		4 / 6 GLN A 210
VAL A 110
MET A 147
PRO A  35
 None
 1.28A 6brdB-5k9nA:
undetectable		 6brdB-5k9nA:
18.26