SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5k9t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
4 / 8 MET A 506
GLU A 210
GLU A 218
ASP A 217
None
MG  A 902 ( 4.9A)
None
None
1.16A 1dtlA-5k9tA:
undetectable
1dtlA-5k9tA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MF1_A_ACTA458_0
(ADENYLOSUCCINATE
SYNTHETASE)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
4 / 4 GLY A 123
LYS A 124
GLY A 125
HIS A 204
None
1.08A 1mf1A-5k9tA:
undetectable
1mf1A-5k9tA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MIC_A_DVAA6_0
(GRAMICIDIN A)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
3 / 3 ALA A 313
VAL A 357
TRP A 349
None
0.88A 1micA-5k9tA:
undetectable
1micB-5k9tA:
undetectable
1micA-5k9tA:
2.29
1micB-5k9tA:
2.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
4 / 7 LEU A  89
LEU A 114
ILE A  64
MET A  21
None
1.04A 1n13I-5k9tA:
undetectable
1n13L-5k9tA:
undetectable
1n13I-5k9tA:
7.29
1n13L-5k9tA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_B_CHCB201_1
(BILE ACID RECEPTOR)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
5 / 12 PHE A 381
ILE A  99
PHE A 401
ILE A 216
TYR A 405
None
1.38A 1osvB-5k9tA:
undetectable
1osvB-5k9tA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_A_DVAA6_0
(MINI-GRAMICIDIN A)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
3 / 3 ALA A 494
VAL A 514
TRP A 541
None
1.00A 1tkqA-5k9tA:
undetectable
1tkqA-5k9tA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
4 / 6 LEU A 286
ARG A 277
THR A 275
LEU A 274
None
0.85A 1v54A-5k9tA:
undetectable
1v54J-5k9tA:
undetectable
1v54A-5k9tA:
21.11
1v54J-5k9tA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
5 / 12 GLY A 177
VAL A 128
ALA A 140
ASP A 133
ALA A 136
None
1.36A 2avdB-5k9tA:
undetectable
2avdB-5k9tA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
4 / 6 LEU A 286
ARG A 277
THR A 275
LEU A 274
None
0.90A 2dyrA-5k9tA:
undetectable
2dyrJ-5k9tA:
undetectable
2dyrA-5k9tA:
21.11
2dyrJ-5k9tA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_J_CHDJ101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
4 / 6 LEU A 286
ARG A 277
THR A 275
LEU A 274
None
0.90A 2dysA-5k9tA:
undetectable
2dysJ-5k9tA:
undetectable
2dysA-5k9tA:
21.11
2dysJ-5k9tA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_W_CHDW101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
4 / 6 LEU A 286
ARG A 277
THR A 275
LEU A 274
None
0.78A 2dysN-5k9tA:
undetectable
2dysW-5k9tA:
undetectable
2dysN-5k9tA:
21.11
2dysW-5k9tA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
4 / 6 LEU A 286
ARG A 277
THR A 275
LEU A 274
None
0.82A 2eijA-5k9tA:
undetectable
2eijJ-5k9tA:
undetectable
2eijA-5k9tA:
21.11
2eijJ-5k9tA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
4 / 8 LEU A 286
ARG A 277
THR A 275
LEU A 274
None
0.73A 2eijN-5k9tA:
undetectable
2eijW-5k9tA:
undetectable
2eijN-5k9tA:
21.11
2eijW-5k9tA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
4 / 7 LEU A 286
ARG A 277
THR A 275
LEU A 274
None
0.80A 2eikA-5k9tA:
undetectable
2eikJ-5k9tA:
undetectable
2eikA-5k9tA:
21.11
2eikJ-5k9tA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
4 / 8 LEU A 286
ARG A 277
THR A 275
LEU A 274
None
0.73A 2eikN-5k9tA:
undetectable
2eikW-5k9tA:
undetectable
2eikN-5k9tA:
21.11
2eikW-5k9tA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
4 / 6 LEU A 286
ARG A 277
THR A 275
LEU A 274
None
0.82A 2eilA-5k9tA:
undetectable
2eilJ-5k9tA:
undetectable
2eilA-5k9tA:
21.11
2eilJ-5k9tA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
4 / 8 LEU A 286
ARG A 277
THR A 275
LEU A 274
None
0.76A 2eilN-5k9tA:
undetectable
2eilW-5k9tA:
undetectable
2eilN-5k9tA:
21.11
2eilW-5k9tA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_A_DVAA35_0
(UBIQUITIN)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
4 / 4 GLN A 533
GLU A 535
ILE A 534
PRO A 529
None
1.32A 2fcnA-5k9tA:
undetectable
2fcnA-5k9tA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
5 / 12 ALA A 136
THR A 130
ALA A 206
PHE A 381
TYR A 380
None
1.18A 2nyrA-5k9tA:
2.4
2nyrA-5k9tA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
3 / 3 ARG A 445
GLU A 444
GLN A 450
None
1.05A 2p16A-5k9tA:
undetectable
2p16A-5k9tA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
4 / 7 LEU A  89
LEU A 114
ILE A  64
MET A  21
None
1.00A 2qqcG-5k9tA:
undetectable
2qqcJ-5k9tA:
undetectable
2qqcG-5k9tA:
7.16
2qqcJ-5k9tA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
4 / 6 TYR A 384
TYR A 380
TYR A 182
ILE A 214
None
1.46A 2xz5A-5k9tA:
undetectable
2xz5B-5k9tA:
undetectable
2xz5A-5k9tA:
15.49
2xz5B-5k9tA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
3 / 3 TYR A 326
VAL A 357
THR A 321
None
0.79A 2ygnA-5k9tA:
undetectable
2ygnA-5k9tA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
4 / 6 LEU A 286
ARG A 277
THR A 275
LEU A 274
None
1.00A 2zxwA-5k9tA:
undetectable
2zxwJ-5k9tA:
undetectable
2zxwA-5k9tA:
21.11
2zxwJ-5k9tA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
4 / 8 LEU A 286
ARG A 277
THR A 275
LEU A 274
None
0.80A 3ablN-5k9tA:
undetectable
3ablW-5k9tA:
undetectable
3ablN-5k9tA:
21.11
3ablW-5k9tA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
4 / 6 LEU A 286
ARG A 277
THR A 275
LEU A 274
None
0.98A 3abmA-5k9tA:
undetectable
3abmJ-5k9tA:
undetectable
3abmA-5k9tA:
21.11
3abmJ-5k9tA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
4 / 8 LEU A 286
ARG A 277
THR A 275
LEU A 274
None
0.92A 3ag3N-5k9tA:
undetectable
3ag3W-5k9tA:
undetectable
3ag3N-5k9tA:
21.11
3ag3W-5k9tA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
4 / 6 LEU A 286
ARG A 277
THR A 275
LEU A 274
None
0.87A 3asnA-5k9tA:
undetectable
3asnJ-5k9tA:
undetectable
3asnA-5k9tA:
21.11
3asnJ-5k9tA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
4 / 8 LEU A 286
ARG A 277
THR A 275
LEU A 274
None
0.78A 3asnN-5k9tA:
undetectable
3asnW-5k9tA:
undetectable
3asnN-5k9tA:
21.11
3asnW-5k9tA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
4 / 6 LEU A 286
ARG A 277
THR A 275
LEU A 274
None
0.88A 3asoA-5k9tA:
undetectable
3asoJ-5k9tA:
undetectable
3asoA-5k9tA:
21.11
3asoJ-5k9tA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
3 / 3 ASN A 179
ASP A 212
GLN A 570
None
0.77A 3eeyC-5k9tA:
2.0
3eeyC-5k9tA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
3 / 3 ASN A 179
ASP A 212
GLN A 570
None
0.78A 3eeyD-5k9tA:
2.3
3eeyD-5k9tA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
3 / 3 ASN A 179
ASP A 212
GLN A 570
None
0.77A 3eeyE-5k9tA:
2.6
3eeyE-5k9tA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
5 / 12 ILE A  99
GLY A 389
ALA A 112
ALA A 206
VAL A 211
None
0.93A 3jb2A-5k9tA:
undetectable
3jb2A-5k9tA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
5 / 12 ILE A  99
GLY A 389
ALA A 112
ALA A 206
VAL A 211
None
0.98A 3jb3A-5k9tA:
undetectable
3jb3A-5k9tA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
4 / 8 LEU A 306
GLY A 352
ALA A 356
ILE A 243
None
0.77A 3jusA-5k9tA:
undetectable
3jusA-5k9tA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
4 / 8 LEU A 306
GLY A 352
ALA A 356
ILE A 243
None
0.77A 3jusA-5k9tA:
undetectable
3jusA-5k9tA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
4 / 7 VAL A 452
VAL A 465
ILE A 474
ARG A 585
None
1.21A 3ms9B-5k9tA:
undetectable
3ms9B-5k9tA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_C_DSFC320_1
(GLR4197 PROTEIN)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
4 / 8 ILE A 438
ILE A 439
VAL A 454
ILE A 474
None
0.86A 3p4wC-5k9tA:
undetectable
3p4wC-5k9tA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
4 / 7 VAL A 239
ILE A 291
SER A 232
TYR A 236
None
0.97A 3pglA-5k9tA:
undetectable
3pglA-5k9tA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
4 / 6 ILE A 556
LEU A 571
ARG A 577
THR A 511
None
1.09A 3wg7A-5k9tA:
undetectable
3wg7J-5k9tA:
undetectable
3wg7A-5k9tA:
21.11
3wg7J-5k9tA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
4 / 7 LEU A 423
SER A 583
GLU A 444
HIS A 555
None
1.25A 4aq7A-5k9tA:
undetectable
4aq7A-5k9tA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
4 / 8 ASN A 486
ALA A 488
THR A 511
LEU A 135
None
0.93A 4ejgB-5k9tA:
undetectable
4ejgB-5k9tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
4 / 6 ASN A 486
ALA A 488
THR A 511
LEU A 135
None
0.98A 4ejgD-5k9tA:
undetectable
4ejgD-5k9tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
3 / 3 SER A 232
TYR A 236
PRO A 228
None
0.83A 4k8cA-5k9tA:
undetectable
4k8cA-5k9tA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
3 / 3 SER A 232
TYR A 236
PRO A 228
None
0.79A 4kahA-5k9tA:
undetectable
4kahA-5k9tA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
3 / 3 SER A 232
TYR A 236
PRO A 228
None
0.80A 4kahB-5k9tA:
undetectable
4kahB-5k9tA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
3 / 3 SER A 232
TYR A 236
PRO A 228
None
0.84A 4kanA-5k9tA:
undetectable
4kanA-5k9tA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
3 / 3 SER A 232
TYR A 236
PRO A 228
None
0.84A 4kanB-5k9tA:
undetectable
4kanB-5k9tA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
3 / 3 SER A 232
TYR A 236
PRO A 228
None
0.81A 4kbeA-5k9tA:
undetectable
4kbeA-5k9tA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
3 / 3 SER A 232
TYR A 236
PRO A 228
None
0.78A 4kbeB-5k9tA:
undetectable
4kbeB-5k9tA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
3 / 3 SER A 232
TYR A 236
PRO A 228
None
0.85A 4lbgA-5k9tA:
undetectable
4lbgA-5k9tA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
3 / 3 SER A 232
TYR A 236
PRO A 228
None
0.82A 4lbgB-5k9tA:
undetectable
4lbgB-5k9tA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
5 / 12 ALA A 120
GLY A 151
ALA A  67
VAL A  71
VAL A  70
None
1.06A 4nkxC-5k9tA:
undetectable
4nkxC-5k9tA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
5 / 12 ALA A 120
GLY A 151
ALA A  67
VAL A  71
VAL A  70
None
1.04A 4nkxD-5k9tA:
undetectable
4nkxD-5k9tA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
3 / 3 MET A  92
ASP A  85
PHE A  84
None
None
ADP  A 901 (-3.4A)
1.00A 4xeyA-5k9tA:
undetectable
4xeyA-5k9tA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
3 / 3 MET A  92
ASP A  85
PHE A  84
None
None
ADP  A 901 (-3.4A)
0.99A 4xeyB-5k9tA:
undetectable
4xeyB-5k9tA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYM_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
5 / 12 LEU A 387
VAL A 211
VAL A 129
PHE A 401
LEU A 407
None
1.49A 5cymA-5k9tA:
undetectable
5cymA-5k9tA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYQ_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
5 / 12 LEU A 387
VAL A 211
VAL A 129
PHE A 401
LEU A 407
None
1.50A 5cyqA-5k9tA:
undetectable
5cyqA-5k9tA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
4 / 8 GLN A 578
GLY A 107
THR A 111
ASN A 415
None
ADP  A 901 (-3.0A)
None
None
0.99A 5hwaA-5k9tA:
undetectable
5hwaA-5k9tA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
4 / 7 LEU A 286
ARG A 277
THR A 275
LEU A 274
None
0.80A 5iy5A-5k9tA:
undetectable
5iy5J-5k9tA:
undetectable
5iy5A-5k9tA:
21.11
5iy5J-5k9tA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
4 / 6 LEU A 286
ARG A 277
THR A 275
LEU A 274
None
1.05A 5x1fA-5k9tA:
undetectable
5x1fJ-5k9tA:
undetectable
5x1fA-5k9tA:
21.11
5x1fJ-5k9tA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
4 / 8 LEU A 286
ARG A 277
THR A 275
LEU A 274
None
0.83A 5xdxN-5k9tA:
undetectable
5xdxW-5k9tA:
undetectable
5xdxN-5k9tA:
21.11
5xdxW-5k9tA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
5 / 12 LEU A  54
LEU A  63
ALA A  67
GLY A 151
LEU A 152
None
0.96A 6b0cD-5k9tA:
undetectable
6b0cD-5k9tA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
5 / 12 LEU A  54
LEU A  63
ALA A  67
GLY A 151
LEU A 152
None
0.92A 6b0iB-5k9tA:
undetectable
6b0iB-5k9tA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
5 / 12 LEU A 387
VAL A 211
VAL A 129
PHE A 401
LEU A 407
None
1.48A 6eliA-5k9tA:
undetectable
6eliA-5k9tA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_0
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
5 / 12 ASN A 142
VAL A 154
THR A 175
ILE A 174
PRO A 159
None
1.20A 6hlpA-5k9tA:
undetectable
6hlpA-5k9tA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
4 / 7 LEU A 286
ARG A 277
THR A 275
LEU A 274
None
0.96A 6nmfA-5k9tA:
undetectable
6nmfJ-5k9tA:
undetectable
6nmfA-5k9tA:
21.11
6nmfJ-5k9tA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli)
4 / 5 LEU A 286
ARG A 277
THR A 275
LEU A 274
None
0.75A 6nmpN-5k9tA:
undetectable
6nmpW-5k9tA:
undetectable
6nmpN-5k9tA:
21.11
6nmpW-5k9tA:
7.95