SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5k9x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_A_DVAA8_0
(ACTINOMYCIN D)		 5k9x TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Legionella
pneumophila) 		3 / 3 THR A 157
THR A 158
PRO A 156
 None
 0.86A 1a7yA-5k9xA:
undetectable		 1a7yA-5k9xA:
3.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9H_A_RAPA108_1
(FKBP12.6)		 5k9x TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Legionella
pneumophila) 		5 / 12 VAL A 232
ILE A 231
TYR A 175
VAL A 129
ILE A 127
 None
 1.15A 1c9hA-5k9xA:
undetectable		 1c9hA-5k9xA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1002_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 5k9x TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Legionella
pneumophila) 		5 / 12 VAL A 123
TYR A 173
TYR A 165
SER A 140
LEU A 148
 None
 1.10A 1fm4A-5k9xA:
undetectable		 1fm4A-5k9xA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE2_0
(ACTINOMYCIN D)		 5k9x TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Legionella
pneumophila) 		3 / 3 THR A 158
PRO A 156
THR A 157
 None
 0.86A 1i3wE-5k9xA:
undetectable		 1i3wE-5k9xA:
3.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_F_DVAF8_0
(ACTINOMYCIN D)		 5k9x TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Legionella
pneumophila) 		3 / 3 THR A 157
THR A 158
PRO A 156
 None
 0.83A 1i3wF-5k9xA:
undetectable		 1i3wF-5k9xA:
3.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD8_0
(ACTINOMYCIN D)		 5k9x TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Legionella
pneumophila) 		3 / 3 THR A 157
THR A 158
PRO A 156
 None
 0.80A 1mnvD-5k9xA:
undetectable		 1mnvD-5k9xA:
3.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 5k9x TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Legionella
pneumophila) 		5 / 11 ILE A  52
ALA A  25
VAL A  81
VAL A  97
ALA A 118
 None
 1.20A 1n4hA-5k9xA:
undetectable		 1n4hA-5k9xA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_A_DVAA8_0
(ACTINOMYCIN X2)		 5k9x TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Legionella
pneumophila) 		3 / 3 THR A 157
THR A 158
PRO A 156
 None
 0.83A 1qfiA-5k9xA:
undetectable		 1qfiA-5k9xA:
3.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_A_CHDA459_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5k9x TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Legionella
pneumophila) 		4 / 6 LEU A 128
VAL A 129
ILE A 127
TRP A 143
 None
 1.01A 1s9qA-5k9xA:
undetectable		 1s9qA-5k9xA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_B_CHDB500_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5k9x TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Legionella
pneumophila) 		4 / 4 LEU A 128
VAL A 129
ILE A 127
TRP A 143
 None
 0.99A 1s9qB-5k9xA:
undetectable		 1s9qB-5k9xA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_A_PAUA6001_0
(PANTOTHENATE KINASE)		 5k9x TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Legionella
pneumophila) 		5 / 9 LEU A  99
GLY A 125
LEU A 148
ILE A   4
ASN A   2
 None
 1.34A 1sq5A-5k9xA:
undetectable		 1sq5A-5k9xA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_B_PAUB6003_0
(PANTOTHENATE KINASE)		 5k9x TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Legionella
pneumophila) 		5 / 10 LEU A  99
GLY A 125
LEU A 148
ILE A   4
ASN A   2
 None
 1.33A 1sq5B-5k9xA:
undetectable		 1sq5B-5k9xA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_C_PAUC6002_0
(PANTOTHENATE KINASE)		 5k9x TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Legionella
pneumophila) 		5 / 9 LEU A  99
GLY A 125
LEU A 148
ILE A   4
ASN A   2
 None
 1.34A 1sq5C-5k9xA:
undetectable		 1sq5C-5k9xA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_D_PAUD6004_0
(PANTOTHENATE KINASE)		 5k9x TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Legionella
pneumophila) 		5 / 10 LEU A  99
GLY A 125
LEU A 148
ILE A   4
ASN A   2
 None
 1.35A 1sq5D-5k9xA:
undetectable		 1sq5D-5k9xA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5k9x TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Legionella
pneumophila) 		3 / 3 LYS A 201
ASP A 266
ASP A 228
 None
 0.94A 2br4D-5k9xA:
undetectable		 2br4D-5k9xA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YDO_A_ADNA400_1
(ADENOSINE RECEPTOR
A2A)		 5k9x TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Legionella
pneumophila) 		5 / 12 LEU A   8
THR A   7
MET A 209
MET A 100
ILE A  98
 None
 1.41A 2ydoA-5k9xA:
undetectable		 2ydoA-5k9xA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)		 5k9x TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Legionella
pneumophila) 		5 / 12 ALA A  25
MET A  68
LEU A  72
GLY A 101
LEU A  99
 None
 1.17A 2yjaB-5k9xA:
undetectable		 2yjaB-5k9xA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_B_CAMB423_0
(CYTOCHROME P450)		 5k9x TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Legionella
pneumophila) 		5 / 11 THR A  33
LEU A  99
LEU A  50
GLY A  51
ASP A  80
 None
 1.07A 3lxiB-5k9xA:
undetectable		 3lxiB-5k9xA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5k9x TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Legionella
pneumophila) 		5 / 12 ALA A  25
TYR A 109
ASP A  79
GLY A  51
ILE A  52
 None
 1.41A 3vwqA-5k9xA:
undetectable		 3vwqA-5k9xA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 5k9x TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Legionella
pneumophila) 		5 / 12 THR A  33
LEU A  99
LEU A  50
GLY A  51
ASP A  80
 None
 1.05A 4c9lA-5k9xA:
undetectable		 4c9lA-5k9xA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)		 5k9x TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Legionella
pneumophila) 		5 / 10 THR A  33
LEU A  99
LEU A  50
GLY A  51
ASP A  80
 None
 1.06A 4c9nB-5k9xA:
undetectable		 4c9nB-5k9xA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 5k9x TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Legionella
pneumophila) 		5 / 12 THR A  33
LEU A  99
LEU A  50
GLY A  51
ASP A  80
 None
 1.04A 4c9oA-5k9xA:
undetectable		 4c9oA-5k9xA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 5k9x TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Legionella
pneumophila) 		5 / 12 THR A  33
LEU A  99
LEU A  50
GLY A  51
ASP A  80
 None
 1.04A 4c9oB-5k9xA:
undetectable		 4c9oB-5k9xA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_B_CAMB423_0
(CYTOCHROME P450)		 5k9x TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Legionella
pneumophila) 		5 / 10 THR A  33
LEU A  99
LEU A  50
GLY A  51
ASP A  80
 None
 1.08A 4c9pB-5k9xA:
undetectable		 4c9pB-5k9xA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 5k9x TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Legionella
pneumophila) 		5 / 9 PHE A 114
ILE A  98
VAL A  97
GLY A  51
VAL A  85
 None
 1.15A 4r20B-5k9xA:
undetectable		 4r20B-5k9xA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5k9x TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Legionella
pneumophila) 		5 / 12 ALA A  71
GLY A  26
LEU A  32
LEU A  48
GLU A  49
 None
 1.04A 5c0oH-5k9xA:
undetectable		 5c0oH-5k9xA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_A_ESTA601_1
(ESTROGEN RECEPTOR)		 5k9x TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Legionella
pneumophila) 		5 / 10 MET A 261
ALA A  45
LEU A  48
GLY A 233
LEU A 236
 None
 1.31A 5dx3A-5k9xA:
undetectable		 5dx3A-5k9xA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 5k9x TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Legionella
pneumophila) 		5 / 10 MET A 261
ALA A  45
LEU A  48
GLY A 233
LEU A 236
 None
 1.25A 5dxbA-5k9xA:
undetectable		 5dxbA-5k9xA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)		 5k9x TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Legionella
pneumophila) 		5 / 11 ALA A  25
MET A  68
LEU A  72
GLY A 101
LEU A  99
 None
 1.23A 5dxbB-5k9xA:
undetectable		 5dxbB-5k9xA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HKG_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B)		 5k9x TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Legionella
pneumophila) 		5 / 12 VAL A 232
ILE A 231
TYR A 175
VAL A 129
ILE A 127
 None
 1.15A 5hkgA-5k9xA:
undetectable		 5hkgA-5k9xA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5k9x TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Legionella
pneumophila) 		4 / 8 GLY A  26
THR A  33
LEU A  50
LEU A  99
 None
 0.82A 5hs1A-5k9xA:
undetectable		 5hs1A-5k9xA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 5k9x TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Legionella
pneumophila) 		5 / 9 SER A 178
GLY A 211
ALA A 227
VAL A 210
ILE A 214
 None
 1.49A 5i3cA-5k9xA:
undetectable		 5i3cA-5k9xA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_1
(PROTEASE PR5-SQV)		 5k9x TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Legionella
pneumophila) 		5 / 9 ALA A  67
ILE A  23
GLY A  51
ILE A  52
PRO A  30
 None
 1.20A 5kr2A-5k9xA:
undetectable		 5kr2A-5k9xA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_1
(PROTEASE PR5-SQV)		 5k9x TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Legionella
pneumophila) 		5 / 9 ALA A  67
ILE A  23
GLY A  51
ILE A  52
PRO A  30
 None
 1.29A 5kr2C-5k9xA:
undetectable		 5kr2C-5k9xA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 5k9x TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Legionella
pneumophila) 		4 / 4 LEU A 153
MET A 163
ILE A 231
LEU A 208
 None
 1.30A 5nfpA-5k9xA:
undetectable		 5nfpA-5k9xA:
22.41