SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5k9z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 5k9z PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 248
VAL A 189
ILE A 228
TYR A 234
LEU A  34
 None
 1.08A 1s19A-5k9zA:
undetectable		 1s19A-5k9zA:
19.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 5k9z PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		7 / 11 GLY A  22
ALA A  24
SER A  25
ASP A  46
ASP A  68
VAL A  69
VAL A 119
 None
 0.40A 1uayA-5k9zA:
28.5		 1uayA-5k9zA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 5k9z PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		7 / 11 GLY A  22
SER A  25
ASP A  46
ASP A  68
VAL A  69
ALA A  96
VAL A 119
 None
 0.89A 1uayA-5k9zA:
28.5		 1uayA-5k9zA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 5k9z PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		7 / 10 GLY A  22
ALA A  24
SER A  25
ASP A  46
ASP A  68
VAL A  69
VAL A 119
 None
 0.39A 1uayB-5k9zA:
28.8		 1uayB-5k9zA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 5k9z PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		7 / 10 GLY A  22
SER A  25
ASP A  46
ASP A  68
VAL A  69
ALA A  96
VAL A 119
 None
 0.91A 1uayB-5k9zA:
28.8		 1uayB-5k9zA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5k9z PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		5 / 12 LEU A 171
GLY A 127
ASP A  80
ALA A 131
ALA A 134
 None
None
GOL  A 301 (-3.2A)
None
GOL  A 301 (-3.9A)
 1.07A 2bm9A-5k9zA:
6.9		 2bm9A-5k9zA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 5k9z PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		5 / 12 GLN A 226
GLY A  28
GLY A  26
LEU A 232
MET A  35
 None
 1.23A 2zw9B-5k9zA:
5.3		 2zw9B-5k9zA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 5k9z PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		4 / 4 LEU A  44
ASP A  90
VAL A  93
THR A  31
 None
 1.25A 3cyxB-5k9zA:
undetectable		 3cyxB-5k9zA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMF_A_SAMA388_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 5k9z PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		5 / 12 GLY A  22
ALA A  30
ASP A  68
VAL A  69
VAL A 119
 None
 0.99A 3dmfA-5k9zA:
7.0		 3dmfA-5k9zA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 5k9z PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		4 / 8 TYR A 161
VAL A 152
ILE A  27
GLY A 192
 None
 0.82A 3hjoA-5k9zA:
undetectable		 3hjoA-5k9zA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5k9z PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		5 / 10 VAL A  42
LEU A  59
GLY A  22
ALA A  23
LEU A  44
 None
 1.08A 4ph9A-5k9zA:
undetectable		 4ph9A-5k9zA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5k9z PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Paraburkholderia
xenovorans) 		5 / 10 VAL A  42
LEU A  59
GLY A  22
ALA A  23
LEU A  44
 None
 1.08A 4ph9B-5k9zA:
undetectable		 4ph9B-5k9zA:
20.04