SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kai'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1CEA_A_ACAA90_1 (PLASMINOGEN)	5kai	CYTOCHROME C-550 (Thermosynechococ cus elongatus)	4 / 8	ASP V 53 TYR V 75 ARG V 66 THR V 58	None HEM V 201 (-4.0A) None HEM V 201 (-4.4A)	1.27A	1ceaA-5kaiV: undetectable 1ceaB-5kaiV: undetectable	1ceaA-5kaiV: 19.51 1ceaB-5kaiV: 19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZDY_A_1YNA602_1 (LANOSTEROL 14-ALPHA DEMETHYLASE)	5kai	CYTOCHROME C-550 (Thermosynechococ cus elongatus)	5 / 12	GLY V 84 PHE V 33 GLY V 44 LEU V 59 THR V 81	None	1.03A	4zdyA-5kaiV: undetectable	4zdyA-5kaiV: 18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZE1_A_X2NA602_1 (LANOSTEROL 14-ALPHA DEMETHYLASE)	5kai	CYTOCHROME C-550 (Thermosynechococ cus elongatus)	5 / 12	GLY V 84 PHE V 33 GLY V 44 LEU V 59 THR V 81	None	1.00A	4ze1A-5kaiV: undetectable	4ze1A-5kaiV: 18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZE2_A_1YNA602_1 (LANOSTEROL 14-ALPHA DEMETHYLASE)	5kai	CYTOCHROME C-550 (Thermosynechococ cus elongatus)	5 / 12	GLY V 84 PHE V 33 GLY V 44 LEU V 59 THR V 81	None	0.98A	4ze2A-5kaiV: undetectable	4ze2A-5kaiV: 18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6E8Q_A_X2NA602_0 (LANOSTEROL 14-ALPHA DEMETHYLASE)	5kai	CYTOCHROME C-550 (Thermosynechococ cus elongatus)	5 / 12	GLY V 84 PHE V 33 GLY V 44 LEU V 59 THR V 81	None	1.00A	6e8qA-5kaiV: undetectable	6e8qA-5kaiV: 18.79

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1CEA_A_ACAA90_1","PLASMINOGEN;PLASMINOGEN","5kai","CYTOCHROME C-550","Thermosynechococcus elongatus",4,"ASP V  53;TYR V  75;ARG V  66;THR V  58","None;HEM V 201 (-4.0A);None;HEM V 201 (-4.4A)","1.27A","1ceaA-5kaiV:undetectable;1ceaB-5kaiV:undetectable","1ceaA-5kaiV:19.51;1ceaB-5kaiV:19.51"],["4ZDY_A_1YNA602_1","LANOSTEROL 14-ALPHA DEMETHYLASE","5kai","CYTOCHROME C-550","Thermosynechococcus elongatus",5,"GLY V  84;PHE V  33;GLY V  44;LEU V  59;THR V  81","None","1.03A","4zdyA-5kaiV:undetectable","4zdyA-5kaiV:18.75"],["4ZE1_A_X2NA602_1","LANOSTEROL 14-ALPHA DEMETHYLASE","5kai","CYTOCHROME C-550","Thermosynechococcus elongatus",5,"GLY V  84;PHE V  33;GLY V  44;LEU V  59;THR V  81","None","1.00A","4ze1A-5kaiV:undetectable","4ze1A-5kaiV:18.75"],["4ZE2_A_1YNA602_1","LANOSTEROL 14-ALPHA DEMETHYLASE","5kai","CYTOCHROME C-550","Thermosynechococcus elongatus",5,"GLY V  84;PHE V  33;GLY V  44;LEU V  59;THR V  81","None","0.98A","4ze2A-5kaiV:undetectable","4ze2A-5kaiV:18.75"],["6E8Q_A_X2NA602_0","LANOSTEROL 14-ALPHA DEMETHYLASE","5kai","CYTOCHROME C-550","Thermosynechococcus elongatus",5,"GLY V  84;PHE V  33;GLY V  44;LEU V  59;THR V  81","None","1.00A","6e8qA-5kaiV:undetectable","6e8qA-5kaiV:18.79"]]