SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kan'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)
5kan HEMAGGLUTININ HA1
(Influenza
A
virus)
5 / 10 ALA A 113
PHE A  87
GLY A 116
GLU A  89
ARG A 269
None
1.35A 1cmcA-5kanA:
undetectable
1cmcB-5kanA:
undetectable
1cmcA-5kanA:
14.24
1cmcB-5kanA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)
5kan HEMAGGLUTININ HA1
(Influenza
A
virus)
5 / 10 GLU A  89
ARG A 269
ALA A 113
PHE A  87
GLY A 116
None
1.38A 1cmcA-5kanA:
undetectable
1cmcB-5kanA:
undetectable
1cmcA-5kanA:
14.24
1cmcB-5kanA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)
5kan HEMAGGLUTININ HA1
(Influenza
A
virus)
4 / 7 LEU A 194
THR A 155
LEU A 251
GLY A 249
None
0.71A 1gtiB-5kanA:
undetectable
1gtiB-5kanA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1867_0
(FPRA)
5kan 16.G.07 HEAVY CHAIN
(Homo
sapiens)
4 / 4 ALA G  40
ARG G  38
GLN G  43
GLU G  46
None
0.72A 1lqtB-5kanG:
undetectable
1lqtB-5kanG:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1424_0
(FPRA)
5kan 16.G.07 HEAVY CHAIN
(Homo
sapiens)
4 / 4 ALA G  40
ARG G  38
GLN G  43
GLU G  46
None
0.75A 1lquB-5kanG:
undetectable
1lquB-5kanG:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)
5kan HEMAGGLUTININ HA1
(Influenza
A
virus)
5 / 10 GLU A  89
ARG A 269
ALA A 113
PHE A  87
GLY A 116
None
1.41A 1mjqC-5kanA:
undetectable
1mjqD-5kanA:
undetectable
1mjqC-5kanA:
14.24
1mjqD-5kanA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)
5kan 16.G.07 LIGHT CHAIN
(Homo
sapiens)
4 / 5 LEU I 179
GLY I 128
PRO I 120
VAL I 132
None
0.91A 2aojA-5kanI:
undetectable
2aojA-5kanI:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)
5kan HEMAGGLUTININ HA1
(Influenza
A
virus)
5 / 12 LEU A 164
ILE A 252
ALA A 253
VAL A 202
TYR A 161
None
1.24A 2japD-5kanA:
undetectable
2japD-5kanA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
5kan 16.G.07 LIGHT CHAIN
(Homo
sapiens)
4 / 6 GLN I  89
TYR I  36
GLN I  38
SER I  98
None
1.23A 3peoG-5kanI:
undetectable
3peoG-5kanI:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)
5kan HEMAGGLUTININ HA1
(Influenza
A
virus)
4 / 7 LEU A 194
TYR A 195
ILE A 252
GLY A 134
None
0.93A 4eq4A-5kanA:
undetectable
4eq4A-5kanA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)
5kan HEMAGGLUTININ HA1
(Influenza
A
virus)
4 / 7 LEU A 194
TYR A 195
ILE A 252
GLY A 134
None
0.93A 4eqlA-5kanA:
undetectable
4eqlA-5kanA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)
5kan HEMAGGLUTININ HA1
(Influenza
A
virus)
4 / 7 LEU A 194
TYR A 195
ILE A 252
GLY A 134
None
0.94A 4eqlB-5kanA:
undetectable
4eqlB-5kanA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)
5kan HEMAGGLUTININ HA1
(Influenza
A
virus)
4 / 7 VAL A 182
ILE A 252
LEU A  70
LEU A  71
None
0.87A 4l1wA-5kanA:
undetectable
4l1wA-5kanA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)
5kan HEMAGGLUTININ HA1
(Influenza
A
virus)
4 / 6 LEU A 194
TYR A 195
ILE A 252
GLY A 134
None
0.92A 4l39A-5kanA:
undetectable
4l39A-5kanA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)
5kan HEMAGGLUTININ HA1
(Influenza
A
virus)
4 / 7 LEU A 194
TYR A 195
ILE A 252
GLY A 134
None
0.92A 4l39B-5kanA:
undetectable
4l39B-5kanA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5kan 16.G.07 HEAVY CHAIN
(Homo
sapiens)
5 / 11 SER G 203
GLY G 149
THR G 150
ALA G 151
THR G 146
None
1.19A 4qvnH-5kanG:
undetectable
4qvnI-5kanG:
undetectable
4qvnH-5kanG:
21.15
4qvnI-5kanG:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5kan 16.G.07 HEAVY CHAIN
(Homo
sapiens)
5 / 10 SER G 203
GLY G 149
THR G 150
ALA G 151
THR G 146
None
1.20A 4qvnV-5kanG:
undetectable
4qvnW-5kanG:
undetectable
4qvnV-5kanG:
21.15
4qvnW-5kanG:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5kan 16.G.07 HEAVY CHAIN
(Homo
sapiens)
5 / 12 SER G 203
GLY G 149
THR G 150
ALA G 151
THR G 146
None
1.17A 4qvpH-5kanG:
undetectable
4qvpI-5kanG:
undetectable
4qvpH-5kanG:
21.15
4qvpI-5kanG:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5kan 16.G.07 HEAVY CHAIN
(Homo
sapiens)
5 / 12 SER G 203
GLY G 149
THR G 150
ALA G 151
THR G 146
None
1.17A 4qvpV-5kanG:
undetectable
4qvpW-5kanG:
undetectable
4qvpV-5kanG:
21.15
4qvpW-5kanG:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5kan 16.G.07 HEAVY CHAIN
(Homo
sapiens)
5 / 11 SER G 203
GLY G 149
THR G 150
ALA G 151
THR G 146
None
1.19A 4qvqH-5kanG:
undetectable
4qvqI-5kanG:
undetectable
4qvqH-5kanG:
21.15
4qvqI-5kanG:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5kan 16.G.07 HEAVY CHAIN
(Homo
sapiens)
5 / 11 SER G 203
GLY G 149
THR G 150
ALA G 151
THR G 146
None
1.19A 4qvqV-5kanG:
undetectable
4qvqW-5kanG:
undetectable
4qvqV-5kanG:
21.15
4qvqW-5kanG:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5kan 16.G.07 HEAVY CHAIN
(Homo
sapiens)
5 / 12 SER G 203
GLY G 149
THR G 150
ALA G 151
THR G 146
None
1.18A 4qvyV-5kanG:
undetectable
4qvyW-5kanG:
undetectable
4qvyV-5kanG:
21.15
4qvyW-5kanG:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5kan 16.G.07 HEAVY CHAIN
(Homo
sapiens)
5 / 11 SER G 203
GLY G 149
THR G 150
ALA G 151
THR G 146
None
1.19A 4qw0H-5kanG:
undetectable
4qw0I-5kanG:
undetectable
4qw0H-5kanG:
21.15
4qw0I-5kanG:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5kan 16.G.07 HEAVY CHAIN
(Homo
sapiens)
5 / 11 SER G 203
GLY G 149
THR G 150
ALA G 151
THR G 146
None
1.19A 4qw0V-5kanG:
undetectable
4qw0W-5kanG:
undetectable
4qw0V-5kanG:
21.15
4qw0W-5kanG:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5kan 16.G.07 HEAVY CHAIN
(Homo
sapiens)
5 / 12 SER G 203
GLY G 149
THR G 150
ALA G 151
THR G 146
None
1.20A 4qw1H-5kanG:
undetectable
4qw1I-5kanG:
undetectable
4qw1H-5kanG:
21.15
4qw1I-5kanG:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5kan 16.G.07 HEAVY CHAIN
(Homo
sapiens)
5 / 12 SER G 203
GLY G 149
THR G 150
ALA G 151
THR G 146
None
1.20A 4qw1V-5kanG:
undetectable
4qw1W-5kanG:
undetectable
4qw1V-5kanG:
21.15
4qw1W-5kanG:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5kan 16.G.07 HEAVY CHAIN
(Homo
sapiens)
5 / 11 SER G 203
GLY G 149
THR G 150
ALA G 151
THR G 146
None
1.19A 4qwuH-5kanG:
undetectable
4qwuI-5kanG:
undetectable
4qwuH-5kanG:
21.15
4qwuI-5kanG:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5kan 16.G.07 HEAVY CHAIN
(Homo
sapiens)
5 / 11 SER G 203
GLY G 149
THR G 150
ALA G 151
THR G 146
None
1.19A 4qwuV-5kanG:
undetectable
4qwuW-5kanG:
undetectable
4qwuV-5kanG:
21.15
4qwuW-5kanG:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_A_ADNA302_1
(FLUORINASE)
5kan 16.G.07 LIGHT CHAIN
(Homo
sapiens)
4 / 7 THR I  97
TYR I  96
PRO I  95
THR I  93
None
1.36A 5b6iA-5kanI:
undetectable
5b6iA-5kanI:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5kan 16.G.07 HEAVY CHAIN
(Homo
sapiens)
5 / 11 SER G 203
GLY G 149
THR G 150
ALA G 151
THR G 146
None
1.17A 5bxnH-5kanG:
undetectable
5bxnI-5kanG:
undetectable
5bxnH-5kanG:
21.15
5bxnI-5kanG:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5kan 16.G.07 HEAVY CHAIN
(Homo
sapiens)
5 / 12 SER G 203
GLY G 149
THR G 150
ALA G 151
THR G 146
None
1.19A 5cz7V-5kanG:
undetectable
5cz7W-5kanG:
undetectable
5cz7V-5kanG:
21.15
5cz7W-5kanG:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)
5kan HEMAGGLUTININ HA1
(Influenza
A
virus)
4 / 8 HIS A  75
ASN A  96
ARG A 224
THR A  65
None
1.25A 5db5A-5kanA:
undetectable
5db5B-5kanA:
undetectable
5db5A-5kanA:
20.62
5db5B-5kanA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5kan 16.G.07 HEAVY CHAIN
(Homo
sapiens)
5 / 12 SER G 203
GLY G 149
THR G 150
ALA G 151
THR G 146
None
1.16A 5l5fH-5kanG:
undetectable
5l5fI-5kanG:
undetectable
5l5fH-5kanG:
21.15
5l5fI-5kanG:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
5kan 16.G.07 HEAVY CHAIN
(Homo
sapiens)
5 / 12 SER G 203
GLY G 149
THR G 150
ALA G 151
THR G 146
None
1.16A 5l5fV-5kanG:
undetectable
5l5fW-5kanG:
undetectable
5l5fV-5kanG:
21.15
5l5fW-5kanG:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)
5kan HEMAGGLUTININ HA1
(Influenza
A
virus)
4 / 8 ASP A  73
ASP A  68
HIS A  75
ARG A 229
None
1.02A 5nekB-5kanA:
undetectable
5nekB-5kanA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)
5kan HEMAGGLUTININ HA1
(Influenza
A
virus)
3 / 3 GLU A  82
LEU A 118
ARG A 150
None
None
NAG  A 403 ( 4.9A)
0.82A 6d8fA-5kanA:
undetectable
6d8fA-5kanA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)
5kan 16.G.07 HEAVY CHAIN
(Homo
sapiens)
5 / 12 VAL G 222
THR G 220
VAL G 226
GLY G 133
VAL G 167
None
0.99A 6drzA-5kanG:
undetectable
6drzA-5kanG:
16.99