SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kar'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		5 / 12 HIS A  30
HIS A 279
PHE A 242
HIS A  97
HIS A 135
 ZN  A 502 (-3.3A)
GOL  A 515 ( 2.6A)
GOL  A 515 (-3.6A)
None
None
 1.34A 1a4lA-5karA:
undetectable		 1a4lA-5karA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FPQ_A_SAMA1699_0
(ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		5 / 10 GLY A  92
ASN A 195
ASP A  94
LEU A 115
VAL A 112
 None
 1.46A 1fpqA-5karA:
undetectable		 1fpqA-5karA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		4 / 8 TYR A  35
GLY A  60
LEU A 344
VAL A 349
 None
 1.20A 1gsfA-5karA:
undetectable		 1gsfA-5karA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		4 / 8 TYR A  35
GLY A  60
LEU A 344
VAL A 349
 None
 1.21A 1gsfB-5karA:
undetectable		 1gsfB-5karA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		4 / 8 TYR A  35
GLY A  60
LEU A 344
VAL A 349
 None
 1.20A 1gsfD-5karA:
undetectable		 1gsfD-5karA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		3 / 3 ASP A  93
HIS A 135
HIS A  30
 ZN  A 501 ( 2.6A)
None
ZN  A 502 (-3.3A)
 0.66A 1oe1A-5karA:
undetectable		 1oe1A-5karA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		3 / 3 ASP A  93
HIS A 135
HIS A  30
 ZN  A 501 ( 2.6A)
None
ZN  A 502 (-3.3A)
 0.66A 1oe3A-5karA:
undetectable		 1oe3A-5karA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		4 / 6 GLY A 272
ILE A 270
GLN A 273
VAL A 372
 None
 1.07A 1rs7B-5karA:
undetectable		 1rs7B-5karA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9U_A_CPFA5002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		4 / 6 PHE A 143
ASN A 201
ASN A 152
GLN A 146
 None
 1.23A 1t9uA-5karA:
undetectable		 1t9uA-5karA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		4 / 6 PHE A 143
ILE A 150
VAL A 154
PHE A 170
 None
 0.95A 2cizA-5karA:
undetectable		 2cizA-5karA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		4 / 6 THR A  95
ASP A  65
THR A 304
ASP A  61
 None
 1.24A 2okcB-5karA:
undetectable		 2okcB-5karA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1470_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		4 / 5 ARG A 188
ALA A 224
ASP A 227
GLU A 229
 None
 1.24A 2xrzA-5karA:
undetectable		 2xrzA-5karA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		3 / 3 ASP A  93
HIS A 135
HIS A  30
 ZN  A 501 ( 2.6A)
None
ZN  A 502 (-3.3A)
 0.67A 2xxgA-5karA:
undetectable		 2xxgA-5karA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		3 / 3 ASP A  93
HIS A 135
HIS A  30
 ZN  A 501 ( 2.6A)
None
ZN  A 502 (-3.3A)
 0.67A 2xxgC-5karA:
undetectable		 2xxgC-5karA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		5 / 12 HIS A 279
THR A 280
HIS A  97
GLY A 316
PHE A 242
 GOL  A 515 ( 2.6A)
None
None
None
GOL  A 515 (-3.6A)
 1.40A 2zj0D-5karA:
undetectable		 2zj0D-5karA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		5 / 11 HIS A 279
HIS A 135
HIS A  97
VAL A  98
PRO A  33
 GOL  A 515 ( 2.6A)
None
None
NAG  A 511 ( 4.0A)
NAG  A 511 ( 3.7A)
 1.37A 2zweA-5karA:
undetectable
2zweB-5karA:
undetectable		 2zweA-5karA:
19.63
2zweB-5karA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		5 / 11 HIS A 279
HIS A 135
HIS A  97
VAL A  98
PRO A  33
 GOL  A 515 ( 2.6A)
None
None
NAG  A 511 ( 4.0A)
NAG  A 511 ( 3.7A)
 1.37A 2zwfA-5karA:
undetectable
2zwfB-5karA:
undetectable		 2zwfA-5karA:
19.63
2zwfB-5karA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWG_B_DAHB98_1
(TYROSINASE
MELC)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		5 / 11 HIS A 279
HIS A 135
HIS A  97
VAL A  98
PRO A  33
 GOL  A 515 ( 2.6A)
None
None
NAG  A 511 ( 4.0A)
NAG  A 511 ( 3.7A)
 1.38A 2zwgA-5karA:
undetectable
2zwgB-5karA:
undetectable		 2zwgA-5karA:
19.63
2zwgB-5karA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		4 / 5 HIS A  30
HIS A  97
ASP A  93
HIS A 135
 ZN  A 502 (-3.3A)
None
ZN  A 501 ( 2.6A)
None
 1.25A 3c0zA-5karA:
undetectable		 3c0zA-5karA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		5 / 12 ASP A 136
GLY A 133
SER A  27
VAL A 112
ALA A 131
 None
 1.27A 3d91B-5karA:
undetectable		 3d91B-5karA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		5 / 12 GLY A 302
GLY A 321
ASP A  65
HIS A  97
ARG A 323
 None
 1.35A 3dlcA-5karA:
undetectable		 3dlcA-5karA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		3 / 3 TYR A  62
ASP A 315
HIS A 402
 None
 0.88A 3e23A-5karA:
undetectable		 3e23A-5karA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		4 / 6 TYR A 197
GLY A 173
THR A 194
GLU A 178
 None
 0.93A 3fpjA-5karA:
undetectable		 3fpjA-5karA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		4 / 7 ASP A  94
ASP A 136
TYR A 151
GLN A 153
 None
 1.07A 3l2vA-5karA:
undetectable		 3l2vA-5karA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_A_CAMA423_0
(CYTOCHROME P450)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		5 / 10 TYR A 151
LEU A 132
GLY A 133
VAL A 108
VAL A 112
 None
 1.33A 3lxiA-5karA:
undetectable		 3lxiA-5karA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		5 / 12 GLY A 235
PRO A 238
VAL A 237
GLU A 243
THR A 280
 None
 1.08A 3p2kB-5karA:
undetectable		 3p2kB-5karA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		5 / 8 ASP A  94
ASP A 136
GLY A 133
TYR A 151
GLN A 153
 None
 1.48A 3s3nA-5karA:
undetectable		 3s3nA-5karA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		4 / 7 ASN A 141
ASP A  28
HIS A 279
HIS A  30
 None
ZN  A 502 (-3.0A)
GOL  A 515 ( 2.6A)
ZN  A 502 (-3.3A)
 0.93A 3t01A-5karA:
undetectable		 3t01A-5karA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		4 / 7 ASN A 195
ASP A  28
HIS A 279
HIS A  30
 None
ZN  A 502 (-3.0A)
GOL  A 515 ( 2.6A)
ZN  A 502 (-3.3A)
 1.01A 3t01A-5karA:
undetectable		 3t01A-5karA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		3 / 3 GLN A 273
PHE A 286
TYR A 259
 None
 0.85A 3ucjB-5karA:
undetectable		 3ucjB-5karA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		3 / 3 GLN A 273
PHE A 286
TYR A 259
 None
 0.82A 3ucjA-5karA:
undetectable		 3ucjA-5karA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		5 / 9 TYR A 151
LEU A 132
GLY A 133
VAL A 108
VAL A 112
 None
 1.35A 4c9kB-5karA:
undetectable		 4c9kB-5karA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		5 / 10 TYR A 151
LEU A 132
GLY A 133
VAL A 108
VAL A 112
 None
 1.33A 4c9nB-5karA:
undetectable		 4c9nB-5karA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_A_CAMA423_0
(CYTOCHROME P450)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		5 / 9 TYR A 151
LEU A 132
GLY A 133
VAL A 108
VAL A 112
 None
 1.33A 4c9pA-5karA:
undetectable		 4c9pA-5karA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_B_CAMB423_0
(CYTOCHROME P450)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		5 / 10 TYR A 151
LEU A 132
GLY A 133
VAL A 108
VAL A 112
 None
 1.34A 4c9pB-5karA:
undetectable		 4c9pB-5karA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		4 / 6 GLY A 272
ILE A 270
GLN A 273
VAL A 372
 None
 1.00A 4d39B-5karA:
undetectable		 4d39B-5karA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_B_SUZB201_1
(TRANSTHYRETIN)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		4 / 8 SER A  27
LEU A 192
ALA A 131
THR A  91
 None
 0.99A 4iklA-5karA:
undetectable
4iklB-5karA:
undetectable		 4iklA-5karA:
16.95
4iklB-5karA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		3 / 3 PRO A  41
LEU A  42
GLN A  51
 None
 0.46A 4pevB-5karA:
undetectable		 4pevB-5karA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA601_0
(LACCASE 2)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		4 / 4 HIS A 279
HIS A 135
HIS A  97
HIS A  30
 GOL  A 515 ( 2.6A)
None
None
ZN  A 502 (-3.3A)
 0.82A 5mhwA-5karA:
undetectable		 5mhwA-5karA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA601_0
(LACCASE 2)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		4 / 4 HIS A 279
HIS A 135
HIS A  97
HIS A  30
 GOL  A 515 ( 2.6A)
None
None
ZN  A 502 (-3.3A)
 0.82A 5mhxA-5karA:
undetectable		 5mhxA-5karA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA601_0
(LACCASE 2)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		4 / 4 HIS A 279
HIS A 135
HIS A  97
HIS A  30
 GOL  A 515 ( 2.6A)
None
None
ZN  A 502 (-3.3A)
 0.82A 5mhyA-5karA:
undetectable		 5mhyA-5karA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA601_0
(LACCASE 2)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		4 / 4 HIS A 279
HIS A 135
HIS A  97
HIS A  30
 GOL  A 515 ( 2.6A)
None
None
ZN  A 502 (-3.3A)
 0.83A 5mhzA-5karA:
undetectable		 5mhzA-5karA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA601_0
(LACCASE 2)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		4 / 4 HIS A 279
HIS A 135
HIS A  97
HIS A  30
 GOL  A 515 ( 2.6A)
None
None
ZN  A 502 (-3.3A)
 0.83A 5mi1A-5karA:
undetectable		 5mi1A-5karA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA601_0
(LACCASE 2)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		4 / 4 HIS A 279
HIS A 135
HIS A  97
HIS A  30
 GOL  A 515 ( 2.6A)
None
None
ZN  A 502 (-3.3A)
 0.83A 5mi2A-5karA:
undetectable		 5mi2A-5karA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA601_0
(LACCASE 2)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		4 / 4 HIS A 279
HIS A 135
HIS A  97
HIS A  30
 GOL  A 515 ( 2.6A)
None
None
ZN  A 502 (-3.3A)
 0.84A 5miaA-5karA:
undetectable		 5miaA-5karA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA601_0
(LACCASE 2)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		4 / 4 HIS A 279
HIS A 135
HIS A  97
HIS A  30
 GOL  A 515 ( 2.6A)
None
None
ZN  A 502 (-3.3A)
 0.84A 5mibA-5karA:
undetectable		 5mibA-5karA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA601_0
(LACCASE 2)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		4 / 4 HIS A 279
HIS A 135
HIS A  97
HIS A  30
 GOL  A 515 ( 2.6A)
None
None
ZN  A 502 (-3.3A)
 0.84A 5micA-5karA:
undetectable		 5micA-5karA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA601_0
(LACCASE 2)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		4 / 4 HIS A 279
HIS A 135
HIS A  97
HIS A  30
 GOL  A 515 ( 2.6A)
None
None
ZN  A 502 (-3.3A)
 0.83A 5midA-5karA:
undetectable		 5midA-5karA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA601_0
(LACCASE 2)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		4 / 4 HIS A 279
HIS A 135
HIS A  97
HIS A  30
 GOL  A 515 ( 2.6A)
None
None
ZN  A 502 (-3.3A)
 0.84A 5mieA-5karA:
undetectable		 5mieA-5karA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		5 / 8 ASP A  93
HIS A 135
HIS A  30
TRP A 250
HIS A 236
 ZN  A 501 ( 2.6A)
None
ZN  A 502 (-3.3A)
None
ZN  A 501 (-3.3A)
 1.28A 5nekD-5karA:
2.1		 5nekD-5karA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UH6_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		5 / 12 LEU A 118
ASP A  28
SER A  74
ILE A 322
HIS A 236
 None
ZN  A 502 (-3.0A)
None
None
ZN  A 501 (-3.3A)
 1.34A 5uh6C-5karA:
0.0		 5uh6C-5karA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHG_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		5 / 12 LEU A 118
ASP A  28
SER A  74
ILE A 322
HIS A 236
 None
ZN  A 502 (-3.0A)
None
None
ZN  A 501 (-3.3A)
 1.36A 5uhgC-5karA:
undetectable		 5uhgC-5karA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		5 / 11 HIS A 279
HIS A 135
HIS A  97
VAL A  98
PRO A  33
 GOL  A 515 ( 2.6A)
None
None
NAG  A 511 ( 4.0A)
NAG  A 511 ( 3.7A)
 1.37A 5z0fA-5karA:
undetectable
5z0fB-5karA:
undetectable		 5z0fA-5karA:
12.97
5z0fB-5karA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		5 / 11 HIS A 279
HIS A 135
HIS A  97
VAL A  98
PRO A  33
 GOL  A 515 ( 2.6A)
None
None
NAG  A 511 ( 4.0A)
NAG  A 511 ( 3.7A)
 1.40A 5z0gA-5karA:
undetectable
5z0gB-5karA:
undetectable		 5z0gA-5karA:
12.97
5z0gB-5karA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0H_B_DAHB98_0
(MELC
TYROSINASE)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		5 / 11 HIS A 279
HIS A 135
HIS A  97
VAL A  98
PRO A  33
 GOL  A 515 ( 2.6A)
None
None
NAG  A 511 ( 4.0A)
NAG  A 511 ( 3.7A)
 1.41A 5z0hA-5karA:
undetectable
5z0hB-5karA:
undetectable		 5z0hA-5karA:
12.97
5z0hB-5karA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		5 / 11 HIS A 279
HIS A 135
HIS A  97
VAL A  98
PRO A  33
 GOL  A 515 ( 2.6A)
None
None
NAG  A 511 ( 4.0A)
NAG  A 511 ( 3.7A)
 1.39A 5z0iA-5karA:
undetectable
5z0iB-5karA:
undetectable		 5z0iA-5karA:
12.97
5z0iB-5karA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		5 / 11 HIS A 279
HIS A 135
HIS A  97
VAL A  98
PRO A  33
 GOL  A 515 ( 2.6A)
None
None
NAG  A 511 ( 4.0A)
NAG  A 511 ( 3.7A)
 1.38A 5z0jA-5karA:
undetectable
5z0jB-5karA:
undetectable		 5z0jA-5karA:
12.97
5z0jB-5karA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		5 / 11 HIS A 279
HIS A 135
HIS A  97
VAL A  98
PRO A  33
 GOL  A 515 ( 2.6A)
None
None
NAG  A 511 ( 4.0A)
NAG  A 511 ( 3.7A)
 1.38A 5z0kA-5karA:
undetectable
5z0kB-5karA:
undetectable		 5z0kA-5karA:
12.97
5z0kB-5karA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		5 / 11 HIS A 279
HIS A 135
HIS A  97
VAL A  98
PRO A  33
 GOL  A 515 ( 2.6A)
None
None
NAG  A 511 ( 4.0A)
NAG  A 511 ( 3.7A)
 1.40A 5z0lA-5karA:
undetectable
5z0lB-5karA:
undetectable		 5z0lA-5karA:
12.97
5z0lB-5karA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		5 / 11 HIS A 279
HIS A 135
HIS A  97
ASP A  32
PRO A  33
 GOL  A 515 ( 2.6A)
None
None
NAG  A 511 ( 4.7A)
NAG  A 511 ( 3.7A)
 1.26A 5z0mA-5karA:
undetectable
5z0mB-5karA:
undetectable		 5z0mA-5karA:
12.72
5z0mB-5karA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		5 / 11 HIS A 279
HIS A 135
HIS A  97
VAL A  98
PRO A  33
 GOL  A 515 ( 2.6A)
None
None
NAG  A 511 ( 4.0A)
NAG  A 511 ( 3.7A)
 1.42A 5z0mA-5karA:
undetectable
5z0mB-5karA:
undetectable		 5z0mA-5karA:
12.72
5z0mB-5karA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CCV_C_RFPC1205_1
(-)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		5 / 12 ASP A  28
SER A  74
LEU A  75
ILE A 322
HIS A 236
 ZN  A 502 (-3.0A)
None
None
None
ZN  A 501 (-3.3A)
 1.46A 6ccvC-5karA:
0.4		 6ccvC-5karA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EUQ_A_DXCA502_0
(MULTIDRUG
TRANSPORTER MDFA)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		5 / 11 ASP A 209
LEU A 192
GLY A 240
LEU A 217
GLN A 273
 None
 1.10A 6euqA-5karA:
undetectable		 6euqA-5karA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		3 / 3 HIS A 387
ARG A 381
ILE A 388
 None
 0.58A 6fgdA-5karA:
undetectable		 6fgdA-5karA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B
(Mus
musculus) 		3 / 3 HIS A 135
HIS A  97
HIS A  30
 None
None
ZN  A 502 (-3.3A)
 0.74A 6giqa-5karA:
undetectable		 6giqa-5karA:
21.44