SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kbd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		 5kbd TUMOR PROTEIN P73
(Homo
sapiens) 		4 / 7 ILE A 271
ARG A 176
ILE A 275
PHE A 290
 None
 1.16A 2q6hA-5kbdA:
undetectable		 2q6hA-5kbdA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 5kbd TUMOR PROTEIN P73
(Homo
sapiens) 		4 / 4 ILE A 175
PHE A 127
ILE A 275
THR A 173
 None
 1.07A 3ia4A-5kbdA:
undetectable		 3ia4A-5kbdA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_MTLA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5kbd TUMOR PROTEIN P73
(Homo
sapiens) 		4 / 6 GLU A 291
ARG A 293
ASP A 305
ASP A 301
 None
 1.34A 4kcnA-5kbdA:
undetectable		 4kcnA-5kbdA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5kbd TUMOR PROTEIN P73
(Homo
sapiens) 		4 / 6 GLU A 291
ARG A 293
ASP A 305
ASP A 301
 None
 1.34A 4kcnB-5kbdA:
undetectable		 4kcnB-5kbdA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 5kbd TUMOR PROTEIN P73
(Homo
sapiens) 		3 / 3 SER A 260
MET A 266
ASP A 202
 None
 0.92A 4mm4B-5kbdA:
undetectable		 4mm4B-5kbdA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5kbd TUMOR PROTEIN P73
(Homo
sapiens) 		3 / 3 CYH A 258
MET A 266
ASN A 267
 ZN  A 401 (-3.1A)
None
None
 1.30A 5qh8A-5kbdA:
undetectable		 5qh8A-5kbdA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_B_6T0B913_0
(TOLL-LIKE RECEPTOR 7)		 5kbd TUMOR PROTEIN P73
(Homo
sapiens) 		5 / 9 VAL A 238
THR A 158
LEU A 253
ILE A 161
THR A 251
 None
 1.42A 5zsfA-5kbdA:
undetectable
5zsfB-5kbdA:
undetectable		 5zsfA-5kbdA:
15.87
5zsfB-5kbdA:
15.87