SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kbf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5kbf CAMP-DEPENDENT
PROTEIN KINASE
REGULATORY SUBUNIT,
PUTATIVE
(Plasmodium
falciparum) 		5 / 10 LEU A 251
ALA A 272
ILE A 236
ALA A 261
LEU A 263
 None
None
CMP  A 501 (-3.8A)
CMP  A 501 (-3.5A)
None
 1.20A 1xp0A-5kbfA:
undetectable		 1xp0A-5kbfA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5kbf CAMP-DEPENDENT
PROTEIN KINASE
REGULATORY SUBUNIT,
PUTATIVE
(Plasmodium
falciparum) 		5 / 12 LEU A 226
LEU A 189
VAL A 296
ILE A 201
LEU A 193
 None
 1.15A 3datA-5kbfA:
undetectable		 3datA-5kbfA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5kbf CAMP-DEPENDENT
PROTEIN KINASE
REGULATORY SUBUNIT,
PUTATIVE
(Plasmodium
falciparum) 		5 / 10 LEU A 226
LEU A 189
VAL A 296
ILE A 201
LEU A 193
 None
 1.16A 3fl9E-5kbfA:
undetectable		 3fl9E-5kbfA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5kbf CAMP-DEPENDENT
PROTEIN KINASE
REGULATORY SUBUNIT,
PUTATIVE
(Plasmodium
falciparum) 		5 / 12 LEU A 226
LEU A 189
VAL A 296
ILE A 201
LEU A 193
 None
 1.14A 3fl9G-5kbfA:
undetectable		 3fl9G-5kbfA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 5kbf CAMP-DEPENDENT
PROTEIN KINASE
REGULATORY SUBUNIT,
PUTATIVE
(Plasmodium
falciparum) 		5 / 10 LEU A 226
LEU A 189
VAL A 296
ILE A 201
LEU A 193
 None
 1.12A 3jw5B-5kbfA:
undetectable		 3jw5B-5kbfA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5kbf CAMP-DEPENDENT
PROTEIN KINASE
REGULATORY SUBUNIT,
PUTATIVE
(Plasmodium
falciparum) 		5 / 12 LEU A 226
LEU A 263
PHE A 205
ILE A 201
SER A 187
 None
 1.19A 3kk6B-5kbfA:
undetectable		 3kk6B-5kbfA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRI_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 5kbf CAMP-DEPENDENT
PROTEIN KINASE
REGULATORY SUBUNIT,
PUTATIVE
(Plasmodium
falciparum) 		5 / 10 TYR A 333
VAL A 398
TYR A 400
TYR A 369
ILE A 390
 None
 1.22A 3vriA-5kbfA:
undetectable
3vriC-5kbfA:
undetectable		 3vriA-5kbfA:
20.18
3vriC-5kbfA:
3.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 5kbf CAMP-DEPENDENT
PROTEIN KINASE
REGULATORY SUBUNIT,
PUTATIVE
(Plasmodium
falciparum) 		5 / 12 TYR A 333
VAL A 398
TYR A 400
TYR A 369
ILE A 390
 None
 1.22A 3vrjA-5kbfA:
undetectable
3vrjC-5kbfA:
undetectable		 3vrjA-5kbfA:
20.18
3vrjC-5kbfA:
4.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 5kbf CAMP-DEPENDENT
PROTEIN KINASE
REGULATORY SUBUNIT,
PUTATIVE
(Plasmodium
falciparum) 		4 / 4 LEU A 263
ILE A 217
TYR A 222
TYR A 319
 None
CMP  A 501 ( 4.9A)
None
CMP  A 501 (-3.6A)
 1.37A 3vt7A-5kbfA:
undetectable		 3vt7A-5kbfA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5kbf CAMP-DEPENDENT
PROTEIN KINASE
REGULATORY SUBUNIT,
PUTATIVE
(Plasmodium
falciparum) 		4 / 7 ARG A 181
GLU A 176
ILE A 180
ASN A 203
 None
 1.04A 4d33B-5kbfA:
undetectable		 4d33B-5kbfA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5kbf CAMP-DEPENDENT
PROTEIN KINASE
REGULATORY SUBUNIT,
PUTATIVE
(Plasmodium
falciparum) 		4 / 8 ARG A 181
GLU A 176
ILE A 180
ASN A 203
 None
 1.04A 4d39A-5kbfA:
undetectable		 4d39A-5kbfA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5kbf CAMP-DEPENDENT
PROTEIN KINASE
REGULATORY SUBUNIT,
PUTATIVE
(Plasmodium
falciparum) 		5 / 12 ILE A 340
ALA A 388
PHE A 375
LEU A 352
ILE A 339
 CMP  A 502 ( 4.1A)
CMP  A 502 (-3.5A)
None
None
None
 1.05A 4p3qA-5kbfA:
undetectable		 4p3qA-5kbfA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 5kbf CAMP-DEPENDENT
PROTEIN KINASE
REGULATORY SUBUNIT,
PUTATIVE
(Plasmodium
falciparum) 		4 / 8 ILE A 413
PHE A 406
TYR A 374
LEU A 381
 None
 0.58A 4qopC-5kbfA:
undetectable		 4qopC-5kbfA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 5kbf CAMP-DEPENDENT
PROTEIN KINASE
REGULATORY SUBUNIT,
PUTATIVE
(Plasmodium
falciparum) 		5 / 12 ILE A 351
GLY A 372
HIS A 309
VAL A 310
ILE A 312
 None
 1.04A 4rvdA-5kbfA:
undetectable		 4rvdA-5kbfA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 5kbf CAMP-DEPENDENT
PROTEIN KINASE
REGULATORY SUBUNIT,
PUTATIVE
(Plasmodium
falciparum) 		5 / 12 PHE A 205
VAL A 256
ILE A 201
LEU A 262
PHE A 190
 None
 1.02A 5im2A-5kbfA:
undetectable		 5im2A-5kbfA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5kbf CAMP-DEPENDENT
PROTEIN KINASE
REGULATORY SUBUNIT,
PUTATIVE
(Plasmodium
falciparum) 		5 / 12 GLU A 422
LEU A 428
LYS A 425
ASP A 439
ALA A 388
 None
CMP  A 502 (-4.3A)
None
None
CMP  A 502 (-3.5A)
 1.20A 5kbwA-5kbfA:
undetectable		 5kbwA-5kbfA:
23.59