SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kbp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)		 5kbp GLYCOSYL HYDROLASE,
FAMILY 38
(Enterococcus
faecalis) 		3 / 3 TRP A 114
ARG A 102
THR A  55
 None
 0.87A 1df7A-5kbpA:
undetectable		 1df7A-5kbpA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 5kbp GLYCOSYL HYDROLASE,
FAMILY 38
(Enterococcus
faecalis) 		4 / 6 ASN A 733
ILE A 689
SER A  99
THR A 308
 None
 1.14A 1h7xA-5kbpA:
1.7		 1h7xA-5kbpA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 5kbp GLYCOSYL HYDROLASE,
FAMILY 38
(Enterococcus
faecalis) 		4 / 6 ASN A 733
ILE A 689
SER A  99
THR A 308
 None
 1.12A 1h7xC-5kbpA:
undetectable		 1h7xC-5kbpA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 5kbp GLYCOSYL HYDROLASE,
FAMILY 38
(Enterococcus
faecalis) 		5 / 12 PHE A 207
ILE A 239
ILE A   8
VAL A   6
VAL A 215
 None
 1.26A 1r5lA-5kbpA:
undetectable		 1r5lA-5kbpA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5kbp GLYCOSYL HYDROLASE,
FAMILY 38
(Enterococcus
faecalis) 		4 / 5 PHE A 123
THR A 133
LEU A 142
ALA A 145
 None
 1.42A 2e1qD-5kbpA:
1.1		 2e1qD-5kbpA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5kbp GLYCOSYL HYDROLASE,
FAMILY 38
(Enterococcus
faecalis) 		4 / 8 GLU A 110
ILE A 106
GLU A 835
LYS A 342
 None
 0.94A 2j9dJ-5kbpA:
undetectable
2j9dK-5kbpA:
undetectable
2j9dL-5kbpA:
undetectable		 2j9dJ-5kbpA:
9.12
2j9dK-5kbpA:
9.12
2j9dL-5kbpA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5kbp GLYCOSYL HYDROLASE,
FAMILY 38
(Enterococcus
faecalis) 		4 / 8 LYS A 342
GLU A 110
ILE A 106
GLU A 835
 None
 0.92A 2j9dJ-5kbpA:
undetectable
2j9dK-5kbpA:
undetectable
2j9dL-5kbpA:
undetectable		 2j9dJ-5kbpA:
9.12
2j9dK-5kbpA:
9.12
2j9dL-5kbpA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		 5kbp GLYCOSYL HYDROLASE,
FAMILY 38
(Enterococcus
faecalis) 		4 / 6 VAL A 450
PHE A 396
PRO A 402
THR A 804
 None
 1.30A 2q6oB-5kbpA:
undetectable		 2q6oB-5kbpA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 5kbp GLYCOSYL HYDROLASE,
FAMILY 38
(Enterococcus
faecalis) 		3 / 3 LEU A 609
PRO A 610
ARG A 670
 None
 0.42A 2qd4B-5kbpA:
undetectable		 2qd4B-5kbpA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA702_0
(FERROCHELATASE)		 5kbp GLYCOSYL HYDROLASE,
FAMILY 38
(Enterococcus
faecalis) 		3 / 3 LEU A 609
PRO A 610
ARG A 670
 None
 0.48A 2qd5A-5kbpA:
undetectable		 2qd5A-5kbpA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 5kbp GLYCOSYL HYDROLASE,
FAMILY 38
(Enterococcus
faecalis) 		5 / 12 LEU A 671
ILE A 580
ARG A 634
LEU A 609
THR A 645
 None
 1.31A 2zzaA-5kbpA:
undetectable		 2zzaA-5kbpA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 5kbp GLYCOSYL HYDROLASE,
FAMILY 38
(Enterococcus
faecalis) 		4 / 6 ASP A 351
LEU A  89
ASP A 231
HIS A  11
 None
 1.09A 3bj8C-5kbpA:
undetectable
3bj8D-5kbpA:
undetectable		 3bj8C-5kbpA:
11.27
3bj8D-5kbpA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5kbp GLYCOSYL HYDROLASE,
FAMILY 38
(Enterococcus
faecalis) 		5 / 12 HIS A 348
TYR A 569
ILE A 353
GLY A 355
SER A 357
 None
 1.19A 3n8xA-5kbpA:
undetectable		 3n8xA-5kbpA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)		 5kbp GLYCOSYL HYDROLASE,
FAMILY 38
(Enterococcus
faecalis) 		5 / 12 ILE A 570
TRP A 190
ASP A 231
PHE A 127
HIS A 350
 None
 1.44A 3phaB-5kbpA:
5.0		 3phaB-5kbpA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_C_ACRC701_1
(ALPHA-GLUCOSIDASE)		 5kbp GLYCOSYL HYDROLASE,
FAMILY 38
(Enterococcus
faecalis) 		5 / 12 ILE A 570
TRP A 190
ASP A 231
PHE A 127
HIS A 350
 None
 1.45A 3phaC-5kbpA:
3.3		 3phaC-5kbpA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_D_ACRD701_1
(ALPHA-GLUCOSIDASE)		 5kbp GLYCOSYL HYDROLASE,
FAMILY 38
(Enterococcus
faecalis) 		5 / 12 ILE A 570
TRP A 190
ASP A 231
PHE A 127
HIS A 350
 None
 1.43A 3phaD-5kbpA:
5.1		 3phaD-5kbpA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 5kbp GLYCOSYL HYDROLASE,
FAMILY 38
(Enterococcus
faecalis) 		4 / 6 MET A 227
LEU A 225
GLN A 268
TYR A 263
 None
 1.34A 3vkxA-5kbpA:
undetectable		 3vkxA-5kbpA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		 5kbp GLYCOSYL HYDROLASE,
FAMILY 38
(Enterococcus
faecalis) 		4 / 6 GLY A 827
LEU A 847
ASN A 846
GLU A 888
 None
 0.99A 3zqtA-5kbpA:
undetectable		 3zqtA-5kbpA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5kbp GLYCOSYL HYDROLASE,
FAMILY 38
(Enterococcus
faecalis) 		3 / 3 TYR A  22
HIS A  26
ARG A  16
 None
 1.03A 4e7bC-5kbpA:
undetectable		 4e7bC-5kbpA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		 5kbp GLYCOSYL HYDROLASE,
FAMILY 38
(Enterococcus
faecalis) 		5 / 9 LEU A 142
GLN A  54
PHE A  86
TYR A 122
LEU A 120
 None
 1.39A 4ltwA-5kbpA:
undetectable		 4ltwA-5kbpA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 5kbp GLYCOSYL HYDROLASE,
FAMILY 38
(Enterococcus
faecalis) 		4 / 6 LEU A  94
HIS A 362
TYR A 569
GLU A 568
 None
 1.13A 4pahA-5kbpA:
undetectable		 4pahA-5kbpA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 5kbp GLYCOSYL HYDROLASE,
FAMILY 38
(Enterococcus
faecalis) 		4 / 7 PHE A 553
LEU A 556
THR A 549
VAL A 725
 None
 1.05A 4wnvD-5kbpA:
undetectable		 4wnvD-5kbpA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5kbp GLYCOSYL HYDROLASE,
FAMILY 38
(Enterococcus
faecalis) 		3 / 3 THR A 126
HIS A 108
LEU A 142
 None
 0.60A 5axdA-5kbpA:
undetectable		 5axdA-5kbpA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		 5kbp GLYCOSYL HYDROLASE,
FAMILY 38
(Enterococcus
faecalis) 		4 / 6 ASP A 125
TYR A  19
TYR A 569
LEU A 754
 None
 1.06A 5bmvB-5kbpA:
undetectable		 5bmvB-5kbpA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA810_1
(CATALASE-PEROXIDASE)		 5kbp GLYCOSYL HYDROLASE,
FAMILY 38
(Enterococcus
faecalis) 		4 / 6 TRP A  14
HIS A 232
LEU A  20
SER A 357
 None
 1.46A 5syjA-5kbpA:
undetectable		 5syjA-5kbpA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB810_1
(CATALASE-PEROXIDASE)		 5kbp GLYCOSYL HYDROLASE,
FAMILY 38
(Enterococcus
faecalis) 		4 / 6 TRP A  14
HIS A 232
LEU A  20
SER A 357
 None
 1.45A 5syjB-5kbpA:
undetectable		 5syjB-5kbpA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 5kbp GLYCOSYL HYDROLASE,
FAMILY 38
(Enterococcus
faecalis) 		4 / 8 LYS A 604
THR A 661
THR A 660
TYR A 775
 None
 1.28A 5x2sI-5kbpA:
undetectable
5x2sJ-5kbpA:
undetectable
5x2sK-5kbpA:
undetectable		 5x2sI-5kbpA:
8.69
5x2sJ-5kbpA:
10.28
5x2sK-5kbpA:
8.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5kbp GLYCOSYL HYDROLASE,
FAMILY 38
(Enterococcus
faecalis) 		4 / 5 ILE A 662
PHE A 641
ARG A 672
THR A 558
 None
 1.30A 5z84N-5kbpA:
2.9
5z84W-5kbpA:
undetectable		 5z84N-5kbpA:
19.96
5z84W-5kbpA:
5.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 5kbp GLYCOSYL HYDROLASE,
FAMILY 38
(Enterococcus
faecalis) 		4 / 4 PRO A 783
MET A 679
GLY A 741
VAL A 725
 None
 1.38A 6ak3A-5kbpA:
2.1		 6ak3A-5kbpA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)		 5kbp GLYCOSYL HYDROLASE,
FAMILY 38
(Enterococcus
faecalis) 		4 / 7 ASN A 347
ARG A 368
GLU A  17
ARG A  16
 None
 0.79A 6b8kA-5kbpA:
undetectable		 6b8kA-5kbpA:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 5kbp GLYCOSYL HYDROLASE,
FAMILY 38
(Enterococcus
faecalis) 		4 / 8 ASN A 347
ARG A 368
GLU A  17
ARG A  16
 None
 0.75A 6b94A-5kbpA:
undetectable		 6b94A-5kbpA:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_A_CXQA507_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 5kbp GLYCOSYL HYDROLASE,
FAMILY 38
(Enterococcus
faecalis) 		4 / 5 ALA A 793
TYR A 411
GLN A 797
ILE A 798
 None
 1.36A 6f6sA-5kbpA:
undetectable
6f6sB-5kbpA:
undetectable		 6f6sA-5kbpA:
6.90
6f6sB-5kbpA:
6.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 5kbp GLYCOSYL HYDROLASE,
FAMILY 38
(Enterococcus
faecalis) 		4 / 8 ILE A 317
ARG A 312
ASN A 407
TYR A 411
 None
 1.10A 6hisA-5kbpA:
2.6
6hisB-5kbpA:
2.6		 6hisA-5kbpA:
7.08
6hisB-5kbpA:
7.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 5kbp GLYCOSYL HYDROLASE,
FAMILY 38
(Enterococcus
faecalis) 		4 / 8 ILE A 317
ARG A 312
ASN A 407
TYR A 411
 None
 1.09A 6hisB-5kbpA:
2.6
6hisC-5kbpA:
2.6		 6hisB-5kbpA:
7.08
6hisC-5kbpA:
7.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 5kbp GLYCOSYL HYDROLASE,
FAMILY 38
(Enterococcus
faecalis) 		4 / 8 ILE A 317
ARG A 312
ASN A 407
TYR A 411
 None
 1.10A 6hisC-5kbpA:
2.6
6hisD-5kbpA:
2.6		 6hisC-5kbpA:
7.08
6hisD-5kbpA:
7.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 5kbp GLYCOSYL HYDROLASE,
FAMILY 38
(Enterococcus
faecalis) 		4 / 8 ILE A 317
ARG A 312
ASN A 407
TYR A 411
 None
 1.08A 6hisD-5kbpA:
2.6
6hisE-5kbpA:
2.6		 6hisD-5kbpA:
7.08
6hisE-5kbpA:
7.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 5kbp GLYCOSYL HYDROLASE,
FAMILY 38
(Enterococcus
faecalis) 		4 / 8 ASN A 407
TYR A 411
ILE A 317
ARG A 312
 None
 1.10A 6hisA-5kbpA:
2.7
6hisE-5kbpA:
2.6		 6hisA-5kbpA:
7.08
6hisE-5kbpA:
7.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 5kbp GLYCOSYL HYDROLASE,
FAMILY 38
(Enterococcus
faecalis) 		4 / 7 GLY A 184
ASN A 129
GLU A 281
GLY A 280
 None
 0.92A 6n7fA-5kbpA:
undetectable		 6n7fA-5kbpA:
6.12