SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kbw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 5kbw RIBOFLAVIN
TRANSPORTER RIBU
(Thermotoga
maritima) 		5 / 12 PHE A  48
LEU A  44
ILE A  90
ALA A  91
VAL A 110
 None
 1.02A 1cbsA-5kbwA:
undetectable		 1cbsA-5kbwA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5kbw RIBOFLAVIN
TRANSPORTER RIBU
(Thermotoga
maritima) 		5 / 10 ALA A 115
PHE A 118
LEU A 122
MET A  79
GLY A  76
 None
None
None
RBF  A 201 (-3.5A)
RBF  A 201 (-2.9A)
 1.50A 1uhoA-5kbwA:
undetectable		 1uhoA-5kbwA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 5kbw RIBOFLAVIN
TRANSPORTER RIBU
(Thermotoga
maritima) 		5 / 12 PHE A  48
LEU A  44
ILE A  90
ALA A  91
VAL A 110
 None
 1.01A 2fr3A-5kbwA:
undetectable		 2fr3A-5kbwA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 5kbw RIBOFLAVIN
TRANSPORTER RIBU
(Thermotoga
maritima) 		3 / 3 TYR A  36
GLU A  40
THR A 112
 None
 1.00A 2y7hB-5kbwA:
undetectable		 2y7hB-5kbwA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 5kbw RIBOFLAVIN
TRANSPORTER RIBU
(Thermotoga
maritima) 		5 / 12 ALA A  43
SER A  86
GLY A  89
ALA A  81
LYS A  62
 None
 0.90A 3douA-5kbwA:
undetectable		 3douA-5kbwA:
22.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 5kbw RIBOFLAVIN
TRANSPORTER RIBU
(Thermotoga
maritima) 		6 / 12 LEU A  34
ASP A  73
GLY A  76
ASN A 123
ASN A 149
LYS A 152
 RBF  A 201 (-4.9A)
RBF  A 201 (-4.0A)
RBF  A 201 (-2.9A)
RBF  A 201 (-2.1A)
RBF  A 201 (-1.8A)
RBF  A 201 (-3.7A)
 0.87A 3p5nA-5kbwA:
24.2		 3p5nA-5kbwA:
33.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 5kbw RIBOFLAVIN
TRANSPORTER RIBU
(Thermotoga
maritima) 		6 / 12 LEU A  34
ASP A  73
GLY A  76
LEU A  83
ASN A 149
LYS A 152
 RBF  A 201 (-4.9A)
RBF  A 201 (-4.0A)
RBF  A 201 (-2.9A)
RBF  A 201 (-4.5A)
RBF  A 201 (-1.8A)
RBF  A 201 (-3.7A)
 1.38A 3p5nA-5kbwA:
24.2		 3p5nA-5kbwA:
33.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 5kbw RIBOFLAVIN
TRANSPORTER RIBU
(Thermotoga
maritima) 		6 / 12 LEU A  34
ASP A  73
GLY A  76
ASN A 123
ASN A 149
LYS A 152
 RBF  A 201 (-4.9A)
RBF  A 201 (-4.0A)
RBF  A 201 (-2.9A)
RBF  A 201 (-2.1A)
RBF  A 201 (-1.8A)
RBF  A 201 (-3.7A)
 0.88A 3p5nB-5kbwA:
24.2		 3p5nB-5kbwA:
33.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 5kbw RIBOFLAVIN
TRANSPORTER RIBU
(Thermotoga
maritima) 		6 / 12 LEU A  34
ASP A  73
GLY A  76
LEU A  83
ASN A 149
LYS A 152
 RBF  A 201 (-4.9A)
RBF  A 201 (-4.0A)
RBF  A 201 (-2.9A)
RBF  A 201 (-4.5A)
RBF  A 201 (-1.8A)
RBF  A 201 (-3.7A)
 1.39A 3p5nB-5kbwA:
24.2		 3p5nB-5kbwA:
33.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPS_A_CHDA211_0
(CMER)		 5kbw RIBOFLAVIN
TRANSPORTER RIBU
(Thermotoga
maritima) 		5 / 10 LEU A  83
ALA A 117
PHE A 118
GLY A 121
PHE A 148
 RBF  A 201 (-4.5A)
None
None
None
RBF  A 201 (-4.9A)
 1.39A 3qpsA-5kbwA:
3.2		 3qpsA-5kbwA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZS3_A_ACTA1226_0
(THAUMATIN-LIKE
PROTEIN)		 5kbw RIBOFLAVIN
TRANSPORTER RIBU
(Thermotoga
maritima) 		4 / 5 GLU A  40
ASP A 156
ASN A 149
PHE A 148
 None
None
RBF  A 201 (-1.8A)
RBF  A 201 (-4.9A)
 1.25A 3zs3A-5kbwA:
0.0		 3zs3A-5kbwA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 5kbw RIBOFLAVIN
TRANSPORTER RIBU
(Thermotoga
maritima) 		3 / 3 TYR A  95
ARG A 101
SER A 100
 None
 1.02A 4dr2I-5kbwA:
undetectable
4dr2J-5kbwA:
undetectable		 4dr2I-5kbwA:
22.70
4dr2J-5kbwA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5kbw RIBOFLAVIN
TRANSPORTER RIBU
(Thermotoga
maritima) 		4 / 7 ASP A  63
ASP A 156
ASN A  80
GLU A  24
 None
None
None
RBF  A 201 (-4.1A)
 1.20A 4fevD-5kbwA:
undetectable		 4fevD-5kbwA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5kbw RIBOFLAVIN
TRANSPORTER RIBU
(Thermotoga
maritima) 		4 / 7 ASP A  63
ASP A 156
ASN A  80
GLU A  24
 None
None
None
RBF  A 201 (-4.1A)
 1.21A 4fevF-5kbwA:
undetectable		 4fevF-5kbwA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5kbw RIBOFLAVIN
TRANSPORTER RIBU
(Thermotoga
maritima) 		4 / 8 ASP A  63
ASP A 156
ASN A  80
GLU A  24
 None
None
None
RBF  A 201 (-4.1A)
 1.21A 4fewD-5kbwA:
undetectable		 4fewD-5kbwA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5kbw RIBOFLAVIN
TRANSPORTER RIBU
(Thermotoga
maritima) 		4 / 8 ASP A  63
ASP A 156
ASN A  80
GLU A  24
 None
None
None
RBF  A 201 (-4.1A)
 1.22A 4fewF-5kbwA:
undetectable		 4fewF-5kbwA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5kbw RIBOFLAVIN
TRANSPORTER RIBU
(Thermotoga
maritima) 		4 / 8 ASP A  63
ASP A 156
ASN A  80
GLU A  24
 None
None
None
RBF  A 201 (-4.1A)
 1.15A 4gkhB-5kbwA:
undetectable		 4gkhB-5kbwA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5kbw RIBOFLAVIN
TRANSPORTER RIBU
(Thermotoga
maritima) 		4 / 7 ASP A  63
ASP A 156
ASN A  80
GLU A  24
 None
None
None
RBF  A 201 (-4.1A)
 1.20A 4gkhG-5kbwA:
undetectable		 4gkhG-5kbwA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5kbw RIBOFLAVIN
TRANSPORTER RIBU
(Thermotoga
maritima) 		4 / 8 ASP A  63
ASP A 156
ASN A  80
GLU A  24
 None
None
None
RBF  A 201 (-4.1A)
 1.19A 4gkiA-5kbwA:
undetectable		 4gkiA-5kbwA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5kbw RIBOFLAVIN
TRANSPORTER RIBU
(Thermotoga
maritima) 		4 / 8 ASP A  63
ASP A 156
ASN A  80
GLU A  24
 None
None
None
RBF  A 201 (-4.1A)
 1.11A 4gkiC-5kbwA:
undetectable		 4gkiC-5kbwA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 5kbw RIBOFLAVIN
TRANSPORTER RIBU
(Thermotoga
maritima) 		3 / 3 TYR A  95
ARG A 101
SER A 100
 None
 1.09A 4lf7I-5kbwA:
undetectable
4lf7J-5kbwA:
undetectable		 4lf7I-5kbwA:
22.70
4lf7J-5kbwA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 5kbw RIBOFLAVIN
TRANSPORTER RIBU
(Thermotoga
maritima) 		3 / 3 TYR A  95
ARG A 101
SER A 100
 None
 1.09A 4lf8I-5kbwA:
undetectable
4lf8J-5kbwA:
undetectable		 4lf8I-5kbwA:
22.70
4lf8J-5kbwA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 5kbw RIBOFLAVIN
TRANSPORTER RIBU
(Thermotoga
maritima) 		3 / 3 GLY A  51
PRO A  52
ALA A  91
 None
 0.41A 4qn9B-5kbwA:
undetectable		 4qn9B-5kbwA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 5kbw RIBOFLAVIN
TRANSPORTER RIBU
(Thermotoga
maritima) 		5 / 12 PHE A  33
LEU A  34
ALA A  31
TYR A 138
ILE A 145
 RBF  A 201 (-4.4A)
RBF  A 201 (-4.9A)
None
None
RBF  A 201 ( 4.6A)
 1.08A 5h8tA-5kbwA:
undetectable		 5h8tA-5kbwA:
20.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KC0_A_RBFA303_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5kbw RIBOFLAVIN
TRANSPORTER RIBU
(Thermotoga
maritima) 		12 / 12 GLU A  24
LEU A  34
LYS A  70
ASP A  73
GLY A  76
MET A  79
ASN A  80
ALA A 119
ASN A 123
ASN A 149
LYS A 152
PHE A 153
 RBF  A 201 (-4.1A)
RBF  A 201 (-4.9A)
RBF  A 201 ( 4.0A)
RBF  A 201 (-4.0A)
RBF  A 201 (-2.9A)
RBF  A 201 (-3.5A)
None
RBF  A 201 (-3.3A)
RBF  A 201 (-2.1A)
RBF  A 201 (-1.8A)
RBF  A 201 (-3.7A)
RBF  A 201 ( 4.7A)
 0.60A 5kc0A-5kbwA:
29.3		 5kc0A-5kbwA:
94.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KC4_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5kbw RIBOFLAVIN
TRANSPORTER RIBU
(Thermotoga
maritima) 		6 / 12 GLU A  24
LEU A  34
ASP A  73
GLY A  76
MET A  79
ASN A 123
 RBF  A 201 (-4.1A)
RBF  A 201 (-4.9A)
RBF  A 201 (-4.0A)
RBF  A 201 (-2.9A)
RBF  A 201 (-3.5A)
RBF  A 201 (-2.1A)
 0.89A 5kc4A-5kbwA:
28.8		 5kc4A-5kbwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KC4_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5kbw RIBOFLAVIN
TRANSPORTER RIBU
(Thermotoga
maritima) 		11 / 12 LEU A  34
LYS A  70
ASP A  73
GLY A  76
MET A  79
ASN A  80
ALA A 119
ASN A 123
ASN A 149
LYS A 152
PHE A 153
 RBF  A 201 (-4.9A)
RBF  A 201 ( 4.0A)
RBF  A 201 (-4.0A)
RBF  A 201 (-2.9A)
RBF  A 201 (-3.5A)
None
RBF  A 201 (-3.3A)
RBF  A 201 (-2.1A)
RBF  A 201 (-1.8A)
RBF  A 201 (-3.7A)
RBF  A 201 ( 4.7A)
 0.62A 5kc4A-5kbwA:
28.8		 5kc4A-5kbwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5kbw RIBOFLAVIN
TRANSPORTER RIBU
(Thermotoga
maritima) 		11 / 12 GLU A  24
LEU A  34
ASP A  73
GLY A  76
MET A  79
ASN A  80
LEU A  83
ALA A 119
ASN A 123
PHE A 148
ASN A 149
 RBF  A 201 (-4.1A)
RBF  A 201 (-4.9A)
RBF  A 201 (-4.0A)
RBF  A 201 (-2.9A)
RBF  A 201 (-3.5A)
None
RBF  A 201 (-4.5A)
RBF  A 201 (-3.3A)
RBF  A 201 (-2.1A)
RBF  A 201 (-4.9A)
RBF  A 201 (-1.8A)
 0.71A 5kc4E-5kbwA:
28.4		 5kc4E-5kbwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5kbw RIBOFLAVIN
TRANSPORTER RIBU
(Thermotoga
maritima) 		11 / 12 GLU A  24
LEU A  34
ASP A  73
GLY A  76
MET A  79
ASN A  80
LEU A  83
ALA A 119
PHE A 148
ASN A 149
LYS A 152
 RBF  A 201 (-4.1A)
RBF  A 201 (-4.9A)
RBF  A 201 (-4.0A)
RBF  A 201 (-2.9A)
RBF  A 201 (-3.5A)
None
RBF  A 201 (-4.5A)
RBF  A 201 (-3.3A)
RBF  A 201 (-4.9A)
RBF  A 201 (-1.8A)
RBF  A 201 (-3.7A)
 0.72A 5kc4E-5kbwA:
28.4		 5kc4E-5kbwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 5kbw RIBOFLAVIN
TRANSPORTER RIBU
(Thermotoga
maritima) 		3 / 3 LYS A  35
ASP A  37
ILE A 145
 RBF  A 201 (-3.3A)
None
RBF  A 201 ( 4.6A)
 0.54A 5kc4E-5kbwA:
28.4		 5kc4E-5kbwA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5kbw RIBOFLAVIN
TRANSPORTER RIBU
(Thermotoga
maritima) 		4 / 5 TYR A  36
VAL A 127
PHE A  87
GLY A 154
 None
 1.20A 6hd4A-5kbwA:
undetectable		 6hd4A-5kbwA:
15.00